Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

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URI
http://hdl.handle.net/11287/618031
Author
Goncalves, I.
Bengtsson, E.
Colhoun, H. M.
Shore, Angela
Palombo, C.
Natali, A.
Edsfeldt, A.
Dunér, P.
Fredrikson, G. N.
Björkbacka, H.
Östling, G.
Aizawa, Kunihiko
Casanova, Francesco
Persson, M.
Gooding, Kim
Strain, David
Khan, F.
Looker, H. C.
Adams, F.
Belch, J.
Pinnoli, S.
Venturi, E.
Kozakova, M.
Gan, L.-M.
Schnecke, V.
Nilsson, J.
Date
2015-07
Journal
Arteriosclerosis, thrombosis, and vascular biology
Type
Journal Article
Research Support, Non-U.S. Gov't
Publisher
American Heart Association
DOI
10.1161/ATVBAHA.115.305631
Rights
Archived with thanks to Arteriosclerosis, thrombosis, and vascular biology
Metadata
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Abstract
Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.
Citation
Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes. 2015, 35 (7):1723-31 Arterioscler. Thromb. Vasc. Biol.
Publisher URL
http://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=25953645
Note
This article is freely available online. Click on the 'Additional Link' above to access the full-text via the publisher's site.
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