Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.
Colhoun, H. M.
Fredrikson, G. N.
Looker, H. C.
JournalArteriosclerosis, thrombosis, and vascular biology
Research Support, Non-U.S. Gov't
PublisherAmerican Heart Association
RightsArchived with thanks to Arteriosclerosis, thrombosis, and vascular biology
MetadataShow full item record
Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.