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    The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells.

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    URI
    http://hdl.handle.net/11287/618027
    Author
    Oram, Richard A.
    Jones, Angus G.
    Besser, R.
    Knight, Bridget A.
    Shields, Beverley M.
    Brown, Richard J.
    Hattersley, Andrew T.
    McDonald, Timothy J.
    Date
    2014-01
    Journal
    Diabetologia
    Type
    Journal Article
    Research Support, Non-U.S. Gov't
    Publisher
    Springer
    DOI
    10.1007/s00125-013-3067-x
    Rights
    Archived with thanks to Diabetologia
    Metadata
    Show full item record
    Abstract
    Classically, type 1 diabetes is thought to proceed to absolute insulin deficiency. Recently developed ultrasensitive assays capable of detecting C-peptide under 5 pmol/l now allow very low levels of C-peptide to be detected in patients with long-standing type 1 diabetes. It is not known whether this low-level endogenous insulin secretion responds to physiological stimuli. We aimed to assess how commonly low-level detectable C-peptide occurs in long-duration type 1 diabetes and whether it responds to a meal stimulus.
    Citation
    The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells. 2014, 57 (1):187-91 Diabetologia
    Publisher URL
    http://dx.doi.org/10.1007/s00125-013-3067-x
    Note
    This article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text via the publisher's site.
    Collections
    • 2014 RD&E publications
    • Diabetes/Endocrine Services
    • Exeter Clinical Laboratory International (Blood Sciences, Genetics, Cellular Pathology & Microbiology)
    • Honorary contracts publications

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