The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells.
Oram, Richard A.
Jones, Angus G.
Knight, Bridget A.
Shields, Beverley M.
Brown, Richard J.
Hattersley, Andrew T.
McDonald, Timothy J.
Research Support, Non-U.S. Gov't
RightsArchived with thanks to Diabetologia
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Classically, type 1 diabetes is thought to proceed to absolute insulin deficiency. Recently developed ultrasensitive assays capable of detecting C-peptide under 5 pmol/l now allow very low levels of C-peptide to be detected in patients with long-standing type 1 diabetes. It is not known whether this low-level endogenous insulin secretion responds to physiological stimuli. We aimed to assess how commonly low-level detectable C-peptide occurs in long-duration type 1 diabetes and whether it responds to a meal stimulus.