The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells.
Author
Oram, Richard A.
Jones, Angus G.
Besser, R.
Knight, Bridget A.
Shields, Beverley M.
Brown, Richard J.
Hattersley, Andrew T.
McDonald, Timothy J.
Date
2014-01Journal
DiabetologiaType
Journal ArticleResearch Support, Non-U.S. Gov't
Publisher
SpringerDOI
10.1007/s00125-013-3067-xRights
Archived with thanks to DiabetologiaMetadata
Show full item recordAbstract
Classically, type 1 diabetes is thought to proceed to absolute insulin deficiency. Recently developed ultrasensitive assays capable of detecting C-peptide under 5 pmol/l now allow very low levels of C-peptide to be detected in patients with long-standing type 1 diabetes. It is not known whether this low-level endogenous insulin secretion responds to physiological stimuli. We aimed to assess how commonly low-level detectable C-peptide occurs in long-duration type 1 diabetes and whether it responds to a meal stimulus.