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    Erythropoietin improves long-term neurological outcome in acute ischemic stroke patients: a randomized, prospective, placebo-controlled clinical trial.

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    Open Access article (499.6Kb)
    URI
    http://hdl.handle.net/11287/610860
    Author
    Tsai, T-H
    Lu, C-H
    Wallace, Christopher G
    Chang, W-N
    Chen, S-F
    Huang, C-R
    Tsai, N-W
    Lan, M-Y
    Sung, P-H
    Liu, C-F
    Yip, H-K
    Date
    2015-02-25
    Journal
    Critical care (London, England)
    Type
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't
    Publisher
    BioMed Central
    DOI
    10.1186/s13054-015-0761-8
    Rights
    Archived with thanks to Critical care (London, England). This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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    Abstract
    Mortality and disability following ischemic stroke (IS) remains unacceptably high with respect to the conventional therapies. This study tested the effect of erythropoietin (EPO) on long-term neurological outcome in patients after acute IS. This study aimed to evaluate the safety and efficacy of two consecutive doses of EPO (5,000 IU/dose, subcutaneously administered at 48 hours and 72 hours after acute IS) on improving the 90-day combined endpoint of recurrent stroke or death that has been previously reported. A secondary objective was to evaluate the long-term (that is, five years) outcome of patients who received EPO.
    Citation
    Erythropoietin improves long-term neurological outcome in acute ischemic stroke patients: a randomized, prospective, placebo-controlled clinical trial. 2015, 19:49 Crit Care
    Publisher URL
    http://ccforum.biomedcentral.com/articles/10.1186/s13054-015-0761-8
    Note
    This article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text via the publisher's site.
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