Urine C-peptide creatinine ratio can be used to assess insulin resistance and insulin production in people without diabetes: an observational study.
Author
Oram, Richard A.
Rawlingson, Andrew
Shields, Beverley M
Bingham, Coralie
Besser, R.
McDonald, Timothy J.
Knight, Bridget A.
Hattersley, Andrew T.
Date
2013-12-18Journal
BMJ openType
Journal ArticleObservational Study
Publisher
BMJDOI
10.1136/bmjopen-2013-003193Rights
Archived with thanks to BMJ openMetadata
Show full item recordAbstract
The current assessment of insulin resistance (IR) in epidemiology studies relies on the blood measurement of C-peptide or insulin. A urine C-peptide creatinine ratio (UCPCR) can be posted from home unaided. It is validated against serum measures of the insulin in people with diabetes. We tested whether UCPCR could be a surrogate measure of IR by examining the correlation of UCPCR with serum insulin, C-peptide and HOMA2 (Homeostasis Model Assessment 2)-IR in participants without diabetes and with chronic kidney disease (CKD).