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    Urine C-peptide creatinine ratio can be used to assess insulin resistance and insulin production in people without diabetes: an observational study.

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    URI
    http://hdl.handle.net/11287/609609
    Author
    Oram, Richard A.
    Rawlingson, Andrew
    Shields, Beverley M
    Bingham, Coralie
    Besser, R.
    McDonald, Timothy J.
    Knight, Bridget A.
    Hattersley, Andrew T.
    Date
    2013-12-18
    Journal
    BMJ open
    Type
    Journal Article
    Observational Study
    Publisher
    BMJ
    DOI
    10.1136/bmjopen-2013-003193
    Rights
    Archived with thanks to BMJ open
    Metadata
    Show full item record
    Abstract
    The current assessment of insulin resistance (IR) in epidemiology studies relies on the blood measurement of C-peptide or insulin. A urine C-peptide creatinine ratio (UCPCR) can be posted from home unaided. It is validated against serum measures of the insulin in people with diabetes. We tested whether UCPCR could be a surrogate measure of IR by examining the correlation of UCPCR with serum insulin, C-peptide and HOMA2 (Homeostasis Model Assessment 2)-IR in participants without diabetes and with chronic kidney disease (CKD).
    Citation
    Urine C-peptide creatinine ratio can be used to assess insulin resistance and insulin production in people without diabetes: an observational study. 2013, 3 (12):e003193 BMJ Open
    Publisher URL
    http://bmjopen.bmj.com/content/3/12/e003193.long
    Note
    This article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text from the publisher's site.
    Collections
    • Diabetes and endocrinology
    • Exeter Clinical Laboratory International (Blood Sciences, Genetics, Cellular Pathology & Microbiology)
    • Honorary contracts publications
    • pre-2014 RD&E publications
    • Renal and nephrology services (kidneys)

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