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    Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study.

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    Open Access article (564.2Kb)
    URI
    http://hdl.handle.net/11287/606576
    Author
    Ruth, K. S.
    Perry, J. R. B.
    Henley, W. E.
    Melzer, David
    Weedon, M. N.
    Murray, Anna
    Date
    2016-04-20
    Journal
    Scientific reports
    Type
    Journal Article
    Publisher
    Nature
    DOI
    10.1038/srep24710
    Rights
    Archived with thanks to Scientific reports. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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    Abstract
    The available oocyte pool is determined before birth, with the majority of oocytes lost before puberty. We hypothesised that events occurring before birth, in childhood or in adolescence ('early-life risk factors') could influence the size of the oocyte pool and thus the timing of menopause. We included cross-sectional data from 273,474 women from the UK Biobank, recruited in 2006-2010 from across the UK. We analysed the association of early menopause with events occurring before adulthood in 11,781 cases (menopause aged under 45) and 173,641 controls (menopause/pre-menopausal at ≥45 years), in models controlling for potential confounding variables. Being part of a multiple birth was strongly associated with early menopause (odds ratio = 1.42, confidence interval: 1.11, 1.82, P = 8.0 × 10(-9), fully-adjusted model). Earlier age at menarche (odds ratio = 1.03, confidence interval: 1.01, 1.06, P = 2.5 × 10(-6)) and earlier year of birth were also associated with EM (odds ratio = 1.02, confidence interval: 1.00, 1.04, P = 8.0 × 10(-6)). We also confirmed previously reported associations with smoking, drinking alcohol, educational level and number of births. We identified an association between multiple births and early menopause, which connects events pre-birth, when the oocyte pool is formed, with reproductive ageing in later life.
    Citation
    Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study. 2016, 6:24710 Sci Rep
    Publisher URL
    http://dx.doi.org/10.1038/srep24710
    Note
    This article is freely available via Open Access. Click on 'Additional Link' above to access the full-text from the publisher's site.
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