Psychiatric morbidity in children with KCNJ11 neonatal diabetes.
Knight, Bridget A.
Ford, T J
Hattersley, Andrew T.
JournalDiabetic medicine : a journal of the British Diabetic Association
RightsArchived with thanks to Diabetic medicine : a journal of the British Diabetic Association
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Mutations in the KCNJ11 gene, which encodes the Kir6.2 subunit of the pancreatic KATP channel, cause neonatal diabetes. KCNJ11 is also expressed in the brain, and ~ 20% of those affected have neurological features, which may include features suggestive of psychiatric disorder. No previous studies have systematically characterized the psychiatric morbidity in people with KCNJ11 neonatal diabetes. We aimed to characterize the types of psychiatric disorders present in children with KCNJ11 mutations, and explore their impact on families.