Should Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c?
Jones, Angus G.
Henley, W. E.
Pearson, E. R.
Hattersley, Andrew T.
Shields, Beverley M
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Baseline HbA1c is a major predictor of response to glucose lowering therapy and therefore a potential confounder in studies aiming to identify other predictors. However, baseline adjustment may introduce error if the association between baseline HbA1c and response is substantially due to measurement error and regression to the mean. We aimed to determine whether studies of predictors of response should adjust for baseline HbA1c.