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    A review of biocompatibility in hernia repair; considerations in vitro and in vivo for selecting the most appropriate repair material.

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    URI
    http://hdl.handle.net/11287/604209
    Author
    Bryan, N.
    Battersby, C.
    Smart, Neil J.
    Hunt, J.
    Date
    2015-04
    Journal
    Hernia : the journal of hernias and abdominal wall surgery
    Type
    Journal Article
    Publisher
    Springer
    DOI
    10.1007/s10029-014-1307-8
    Rights
    Archived with thanks to Hernia : the journal of hernias and abdominal wall surgery
    Metadata
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    Abstract
    Repair of hernia typically makes use of a prosthetic material; synthetic or biologic in nature. Any material which enters the body is subject to interrogation by the inflammation and immune system in addition to numerous other cell families, the outcome of which ultimately determines the success of the repair. In this review, we discuss the fundamental biology which occurs in situ when a biomaterial associates with a tissue, compare and contrast the techniques available to predict this in vitro, and review how features of hernia repair materials specifically may manipulate tissue interrogation and integration. Finally, we conclude our article by examining how biocompatibility impacts surgical practise and how a better understanding of the manner by which materials and tissues interact could benefit hernia repair.
    Citation
    A review of biocompatibility in hernia repair; considerations in vitro and in vivo for selecting the most appropriate repair material. 2015, 19 (2):169-78 Hernia
    Publisher URL
    http://dx.doi.org/10.1007/s10029-014-1307-8
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    • 2015 RD&E publications
    • Colorectal Surgery
    • HeSRU publications

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