Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.
Wood, A. R.
Jones, S. E.
Tuke, M. A.
Ruth, K. S.
Freathy, Rachel M.
Frayling, T. M.
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Genome-wide association (GWA) studies have identified hundreds of common genetic variants associated with obesity and type 2 diabetes. These studies have usually focused on additive association tests. Identifying deviations from additivity may provide new biological insights and explain some of the missing heritability for these diseases.
Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. 2016 Jun;59(6):1214-21: Diabetologia
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