Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.
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Authors
Wood, A. R.
Tyrrell, J.
Beaumont, R.
Jones, S. E.
Tuke, M. A.
Ruth, K. S.
Yaghootkar, Hanieh
Freathy, Rachel M.
Murray, Anna
Frayling, T. M.
Journal
Diabetologia
Type
Journal Article
Publisher
Springer
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Genome-wide association (GWA) studies have identified hundreds of common genetic variants associated with obesity and type 2 diabetes. These studies have usually focused on additive association tests. Identifying deviations from additivity may provide new biological insights and explain some of the missing heritability for these diseases.
Citation
Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. 2016 Jun;59(6):1214-21: Diabetologia
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