• Using simulation and machine learning to maximise the benefit of intravenous thrombolysis in acute stroke in England and Wales: the SAMueL modelling and qualitative study 

  Allen, M.; James, C.; Frost, J.; Liabo, K.; Pearn, K.; Monks, T.; Zhelev, Z.; Logan, S.; Everson, R.; James, M.; Stein, K. (NIHR Journals Library, 2022-10-01)

  BACKGROUND: Stroke is a common cause of adult disability. Expert opinion is that about 20% of patients should receive thrombolysis to break up a clot causing the stroke. Currently, 11–12% of patients in England and Wales ...

• Development of a treatment selection algorithm for SGLT2 and DPP-4 inhibitor therapies in people with type 2 diabetes: a retrospective cohort study 

  Dennis, J. M.; Young, K. G.; McGovern, A. P.; Mateen, B. A.; Vollmer, S. J.; Simpson, M. D.; Henley, W. E.; Holman, R. R.; Sattar, N.; Pearson, E. R.; Hattersley, A. T.; Jones, A. G.; Shields, B. M. (Elsevier, 2022-12-01)

  BACKGROUND: Current treatment guidelines do not provide recommendations to support the selection of treatment for most people with type 2 diabetes. We aimed to develop and validate an algorithm to allow selection of optimal ...

• Detailed statistical analysis plan for a randomised controlled trial of the effects of a modified muscle sparing posterior technique (SPAIRE) in hip hemiarthroplasty for displaced intracapsular fractures on post-operative function compared to a standard lateral approach: HemiSPAIRE 

  Ball, S.; McAndrew, A.; Aylward, A.; Cockcroft, E.; Gordon, E.; Kerridge, A.; Morgan-Trimmer, S.; Powell, R.; Price, A.; Rhodes, S.; Timperley, A. J.; van Horik, J.; Wickins, R.; Charity, J. (BioMed Central, 2022-11-05)

  BACKGROUND: The HemiSPAIRE trial is being conducted to determine whether a modified muscle sparing technique (SPAIRE-Save Piriformis and Internus, Repairing Externus") in hip hemiarthroplasty brings clinical benefits ...

• Safe prescribing in cancer patients during the COVID-19 pandemic: A new initiative from the UK Cancer Coronavirus Project (UKCCP) team 

  Appanna, N.; Patel, G.; Burke, E.; Burnett, A.; Clark, J.; Mew, R.; Khan, S.; Little, M.; Liu, J.; Panneerselvam, H.; Patel, V.; Platt, J.; Tilby, M.; Watts, I.; Harper-Wynne, C.; Lee, L. Y. (Wiley, 2022-12-01)

• Infliximab and Tofacitinib Attenuate Neutralizing Antibody Responses Against SARS-CoV-2 Ancestral and Omicron Variants in Inflammatory Bowel Disease Patients Following 3 Doses of COVID-19 Vaccine 

  Liu, Z.; Alexander, J. L.; Lin, K. W.; Ahmad, T.; Pollock, K. M.; Powell, N. (Elsevier, 2022-10-19)

• HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress 

  Sala-Gaston, J.; Pedrazza, L.; Ramirez, J.; Martinez-Martinez, A.; Rawlins, L. E.; Baple, E. L.; Crosby, A. H.; Mayor, U.; Ventura, F.; Rosa, J. L. (Springer, 2022-10-14)

  HERC2 gene encodes an E3 ubiquitin ligase involved in several cellular processes by regulating the ubiquitylation of different protein substrates. Biallelic pathogenic sequence variants in the HERC2 gene are associated ...

• Safety and Efficacy of the NVX-CoV2373 COVID-19 Vaccine at Completion of the Placebo-Controlled Phase of a Randomized Controlled Trial 

  Heath, P. T.; Galiza, E. P.; Baxter, D. N.; Boffito, M.; Browne, D.; Burns, F.; Chadwick, D. R.; Clark, R.; Cosgrove, C. A.; Galloway, J.; Goodman, A. L.; Heer, A.; Higham, A.; Iyengar, S.; Jeanes, C.; Kalra, P. A.; Kyriakidou, C.; Bradley, J. M.; Munthali, C.; Minassian, A. M.; McGill, F.; Moore, P.; Munsoor, I.; Nicholls, H.; Osanlou, O.; Packham, J.; Pretswell, C. H.; Francisco Ramos, A. S.; Saralaya, D.; Sheridan, R. P.; Smith, R.; Soiza, R. L.; Swift, P. A.; Thomson, E. C.; Turner, J.; Viljoen, M. E.; Fries, L.; Cho, I.; McKnight, I.; Glenn, G.; Rivers, E. J.; Robertson, A.; Alves, K.; Smith, K.; Toback, S. (Oxford University Press, 2022-10-10)

  BACKGROUND: The recombinant protein-based vaccine, NVX-CoV2373, demonstrated 89.7% efficacy against COVID-19 in a phase 3, randomized, observer-blinded, placebo-controlled trial in the United Kingdom. The protocol was ...

• COVID-19 pandemic interim Foundation Year 1 post and confidence in core skills and competencies: a longitudinal survey 

  Gatti, C. A.; Parker-Conway, K.; Okorie, M. (BMJ, 2022-11-02)

  OBJECTIVES: The interim Foundation Year 1 (FiY1) post was created in response to the COVID-19 pandemic to help bolster the workforce and manage increased clinical pressures. This study aimed to assess the impact of the ...

• Bi-allelic CAMSAP1 variants cause a clinically recognizable neuronal migration disorder 

  Khalaf-Nazzal, R.; Fasham, J.; Inskeep, K. A.; Blizzard, L. E.; Leslie, J. S.; Wakeling, M. N.; Ubeyratna, N.; Mitani, T.; Griffith, J. L.; Baker, W.; Al-Hijawi, F.; Keough, K. C.; Gezdirici, A.; Pena, L.; Spaeth, C. G.; Turnpenny, P. D.; Walsh, J. R.; Ray, R.; Neilson, A.; Kouranova, E.; Cui, X.; Curiel, D. T.; Pehlivan, D.; Akdemir, Z. C.; Posey, J. E.; Lupski, J. R.; Dobyns, W. B.; Stottmann, R. W.; Crosby, A. H.; Baple, E. L. (Cell Press, 2022-11-03)

  Non-centrosomal microtubules are essential cytoskeletal filaments that are important for neurite formation, axonal transport, and neuronal migration. They require stabilization by microtubule minus-end-targeting proteins ...

• The Impact of COVID Vaccination on Symptoms of Long COVID: An International Survey of People with Lived Experience of Long COVID 

  Strain, W. D.; Sherwood, O.; Banerjee, A.; Van der Togt, V.; Hishmeh, L.; Rossman, J. (MDPI, 2022-04-21)

  Long COVID is a multi-system syndrome following SARS-CoV-2 infection with persistent symptoms of at least 4 weeks, and frequently for several months. It has been suggested that there may be an autoimmune component. There ...

• The Impact of COVID Vaccination on Symptoms of Long COVID: An International Survey of People with Lived Experience of Long COVID 

  Strain, W. D.; Sherwood, O.; Banerjee, A.; Van der Togt, V.; Hishmeh, L.; Rossman, J. (MDPI, 2022-04-21)

  Long COVID is a multi-system syndrome following SARS-CoV-2 infection with persistent symptoms of at least 4 weeks, and frequently for several months. It has been suggested that there may be an autoimmune component. There ...

• Post-acute COVID syndrome (long COVID): What should radiographers know and the potential impact for imaging services 

  Alghamdi, F.; Owen, R.; Ashton, R. E. M.; Obotiba, A. D.; Meertens, R. M.; Hyde, E.; Faghy, M. A.; Knapp, K. M.; Rogers, P.; Strain, W. D. (Elsevier, 2022-09-12)

  OBJECTIVES: The COVID-19 pandemic caused an unprecedented health crisis resulting in over 6 million deaths worldwide, a figure, which continues to grow. In addition to the excess mortality, there are individuals who recovered ...

• Incomplete Penetrance and Variable Expressivity: From Clinical Studies to Population Cohorts 

  Kingdom, R.; Wright, C. F. (Frontiers Media, 2022-08-20)

  The same genetic variant found in different individuals can cause a range of diverse phenotypes, from no discernible clinical phenotype to severe disease, even among related individuals. Such variants can be said to display ...

• Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study 

  Mullins, E.; Perry, A.; Banerjee, J.; Townson, J.; Grozeva, D.; Milton, R.; Kirby, N.; Playle, R.; Bourne, T.; Lees, C. (Elsevier, 2022-09-01)

  OBJECTIVE: To assess perinatal outcomes for pregnancies affected by suspected or confirmed SARS-CoV-2 infection. METHODS: Prospective, web-based registry. Pregnant women were invited to participate if they had suspected ...

• The effect of the COVID-19 pandemic on severe asthma care in Europe: will care change for good? 

  Eger, K.; Paroczai, D.; Bacon, A.; Schleich, F.; Sergejeva, S.; Bourdin, A.; Vachier, I.; Zervas, E.; Katsoulis, K.; Papapetrou, D.; Kostikas, K.; Csoma, Z.; Heffler, E.; Canonica, G. W.; Grisle, I.; Bieksiene, K.; Palacionyte, J.; Ten Brinke, A.; Hashimoto, S.; Smeenk, Fwjm; Braunstahl, G. J.; van der Sar, S.; Mihălţan, F.; Nenasheva, N.; Peredelskaya, M.; Zvezdin, B.; Čekerevac, I.; Hromiš, S.; Ćupurdija, V.; Lazic, Z.; Milenkovic, B.; Dimic-Janjic, S.; Yasinska, V.; Dahlén, B.; Bossios, A.; Lazarinis, N.; Aronsson, D.; Egesten, A.; Munir, A. K. M.; Ahlbeck, L.; Janson, C.; Škrgat, S.; Edelbaher, N.; Leuppi, J.; Jaun, F.; Rüdiger, J.; Pavlov, N.; Gianella, P.; Fischer, R.; Charbonnier, F.; Chaudhuri, R.; Smith, S. J.; Doe, S.; Fawdon, M.; Masoli, M.; Heaney, L.; Haitchi, H. M.; Kurukulaaratchy, R.; Fulton, O.; Frankemölle, B.; Gibson, T.; Needham, K.; Howarth, P.; Djukanovic, R.; Bel, E.; Hyland, M. (European Respiratory Society, 2022-04-01)

  BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has put pressure on healthcare services, forcing the reorganisation of traditional care pathways. We investigated how physicians taking care of severe asthma ...

• Performance of the SarQoL quality of life tool in a UK population of older people with probable sarcopenia and implications for use in clinical trials: findings from the SarcNet registry 

  Witham, M. D.; Heslop, P.; Dodds, R. M.; Clegg, A. P.; Hope, S. V.; McDonald, C.; Smithard, D.; Storey, B.; Tan, A. L.; Thornhill, A.; Sayer, A. A. (BioMed Central, 2022-04-27)

  BACKGROUND: The Sarcopenia Quality of Life (SarQoL) questionnaire is a disease-specific sarcopenia quality of life tool. We aimed to independently assess SarQoL with a particular focus on its suitability as a clinical trial ...

• Experiences of 'traditional' and 'one-stop' MRI-based prostate cancer diagnostic pathways in England: a qualitative study with patients and GPs 

  Merriel, S. W. D.; Archer, S.; Forster, A. S.; Eldred-Evans, D.; McGrath, J.; Ahmed, H. U.; Hamilton, W.; Walter, F. M. (BMJ, 2022-07-26)

  OBJECTIVES: This study aimed to understand and explore patient and general practitioner (GP) experiences of 'traditional' and 'one-stop' prostate cancer diagnostic pathways in England. DESIGN: Qualitative study using ...

• Assessing whether genetic scores explain extra variation in birthweight, when added to clinical and anthropometric measures 

  Haulder, M.; Hughes, A. E.; Beaumont, R. N.; Knight, B. A.; Hattersley, A. T.; Shields, B. M.; Freathy, R. M. (BMC, 2022-08-25)

  BACKGROUND: Human birthweight is a complex, multifactorial trait. Maternal characteristics contribute to birthweight variation by influencing the intrauterine environment. Variation explained by genetic effects is also ...

• Heterogeneity in phenotype, disease progression and drug response in type 2 diabetes 

  Nair, A. T. N.; Wesolowska-Andersen, A.; Brorsson, C.; Rajendrakumar, A. L.; Hapca, S.; Gan, S.; Dawed, A. Y.; Donnelly, L. A.; McCrimmon, R.; Doney, A. S. F.; Palmer, C. N. A.; Mohan, V.; Anjana, R. M.; Hattersley, A. T.; Dennis, J. M.; Pearson, E. R. (Nature, 2022-05-01)

  Type 2 diabetes (T2D) is a complex chronic disease characterized by considerable phenotypic heterogeneity. In this study, we applied a reverse graph embedding method to routinely collected data from 23,137 Scottish patients ...

• COVID-19 in Patients with Glomerular Disease: Follow-Up Results from the IRoc-GN International Registry 

  Waldman, M.; Soler, M. J.; García-Carro, C.; Lightstone, L.; Turner-Stokes, T.; Griffith, M.; Torras, J.; Martinez Valenzuela, L.; Bestard, O.; Geddes, C.; Flossmann, O.; Budge, K. L.; Cantarelli, C.; Fiaccadori, E.; Delsante, M.; Morales, E.; Gutierrez, E.; Niño-Cruz, J. A.; Martinez-Rueda, A. J.; Comai, G.; Bini, C.; La Manna, G.; Slon, M. F.; Manrique, J.; Avello, A.; Fernandez-Prado, R.; Ortiz, A.; Marinaki, S.; Martin Varas, C. R.; Rabasco Ruiz, C.; Sierra-Carpio, M.; García-Agudo, R.; Fernández Juárez, G.; Hamilton, A. J.; Bruchfeld, A.; Chrysochou, C.; Howard, L.; Sinha, S.; Leach, T.; Agraz Pamplona, I.; Maggiore, U.; Cravedi, P. (Unknown, 2022-02-24)

  BACKGROUND: The acute and long-term effects of severe acute respiratory syndrome coronavirus 2 infection in individuals with GN are still unclear. To address this relevant issue, we created the International Registry of ...

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