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    Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model.

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    URI
    http://hdl.handle.net/11287/596645
    Author
    Spiers, H
    Hannon, Eilis
    Wells, S
    Williams, B
    Fernandes, C
    Mill, Jonathan
    Date
    2016-02-06
    Journal
    Mechanisms of ageing and development
    Type
    Comment
    Publisher
    Elsevier
    DOI
    10.1016/j.mad.2016.02.001
    Rights
    Archived with thanks to Mechanisms of ageing and development
    Metadata
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    Abstract
    Epigenetic disruption has been implicated in many diseases of aging, and age-associated DNA methylation changes at specific genomic loci in humans are strongly correlated with chronological age. The aim of this study was to explore the specificity of selected age-associated differentially methylated positions (aDMPs) identified in human epidemiological studies by quantifying DNA methylation across multiple tissues in homologous regions of the murine genome. We selected four high-confidence aDMPs (located in the vicinity of the ELOVL2, GLRA1, MYOD1 and PDE4C genes) and quantified DNA methylation across these regions in four tissues (blood, lung, cerebellum and hippocampus) from male and female C57BL/6J mice, ranging in age from fetal (embryonic day 17) to 630 days. We observed tissue-specific age-associated changes in DNA methylation that was directionally consistent with those observed in humans. These findings lend further support to the notion that changes in DNA methylation are associated with chronological age and suggest that these processes are often conserved across tissues and between mammalian species. Our data highlight the relevance of utilizing model systems, in which environmental and genetic influences can be carefully controlled, for the further study of these phenomena.
    Citation
    Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. 2016: Mech. Ageing Dev.
    Publisher URL
    http://linkinghub.elsevier.com/retrieve/pii/S0047-6374(16)30006-9
    Note
    The article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text from the publisher's site.
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