Systemic inflammatory cytokine analysis to monitor biomaterial augmented tissue healing.
Author
Bryan, N
Ashwin, H
Smart, Neil J.
Weyhe, D
Wohlert, S
Bayon, Y
Hunt, J A
Date
2016-02-08Journal
The International journal of artificial organsType
Journal ArticlePublisher
WichtigDOI
10.5301/ijao.5000450Rights
Archived with thanks to The International journal of artificial organs.Metadata
Show full item recordAbstract
Hernias can be repaired by reinforcement of damaged fascia using biomaterials to provide stabilisation. Repair materials are usually porous, through which cells infiltrate, proliferate and secrete ECM. Their efficacy relies on good tissue integration and resolution of host defence mechanisms. Therefore, understanding the dynamics by which biomaterials interact with tissue will provide knowledge to advance prosthesis design. Furthermore, determining host response in real time would provide significant advantage both clinically and scientifically over the current terminal process of histology.