Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial.
Clarke, Carl E
PD MED Collaborative Group incl:
Fenwick, Gill M
Gormley, Kevin (Joe)
Gutowski, Nicholas J.
Pearce, Vaughan R
JournalLancet (London, England)
Randomized Controlled Trial
MetadataShow full item record
Whether initial treatment for Parkinson's disease should consist of levodopa, dopamine agonists, or monoamine oxidase type B inhibitors (MAOBI) is uncertain. We aimed to establish which of these three classes of drug, as initial treatment, provides the most effective long-term control of symptoms and best quality of life for people with early Parkinson's disease.