Delayed absorbable synthetic plug (GORE BIO-A ) for the treatment of fistula in ano: a systematic review
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Narang, Sunil K.
Alam, Nasra N
Daniels, Ian R.
Smart, Neil J.
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
AIM: Recent advances in the treatment of fistula-in-ano have focused on surgical techniques that preserve sphincter integrity. Plugs that obliterate the lumen of the fistula track have been proposed as one such method and may be derived from biologic or delayed absorbable synthetic materials. Biologic plugs have highly variable results and have not been widely adopted. The aim of this systematic review was to assess the effectiveness and safety of delayed absorbable synthetic plug (GORE(R) BIO-A) for treatment of anal fistula. METHOD: A systematic review of all English language literature relevant to the use of a plug to treat anal fistula, published between 1 January 2008 and 15 February 2015 was carried out using MEDLINE, EMBASE and the Cochrane Library of Systematic Reviews/Controlled Trials for relevant literature. Relevant articles were identified, quality assessed using the MINORS criteria and data extracted by two independent researchers (SKN and NNA). The identified articles were assessed with regards to fistula healing rate, duration of follow up and complication rates related to the use of delayed absorbable synthetic fistula plugs. RESULTS: Twenty six potential articles were identified from the literature search. Using the pre-defined inclusion and exclusion criteria, six were included for the final analysis, data extraction and data synthesis. Of these included in the review only three were prospective in design. Complete data were available for 187 of the 221 patients who underwent this treatment. The age of the participants ranged from 19 to 82 years. The fistula healing rates were reported to be between 15.8% and 72.7% at a follow up ranging between two and 19 months. Early or delayed plug extrusion occurred in 16 (8.5%) of the 187 patients. Deterioration in continence was reported in 11 (5.8%) of 187 patients. CONCLUSION: The delayed absorbable synthetic (GORE(R) BIO-A) fistula plug has insufficient high quality data to draw meaningful conclusions regarding its effectiveness. It does, however, appear to be a simple and safe technique associated with low complication rates and a minor deterioration in continence in a few cases. This article is protected by copyright. All rights reserved.
Colorectal Dis. 2016.18(1) p37-44