• Login
    View Item 
    •   RD&E Research Repository Home
    • All RD&E publications by year
    • 2015 RD&E publications
    • View Item
    •   RD&E Research Repository Home
    • All RD&E publications by year
    • 2015 RD&E publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

    Thumbnail
    URI
    http://hdl.handle.net/11287/593942
    Author
    Peterlongo, P.
    Chang-Claude, J.
    Moysich, K. B.
    Rudolph, A.
    Schmutzler, R. K.
    Simard, J.
    Soucy, P.
    Eeles, R. A.
    Easton, D. F.
    Hamann, U.
    Wilkening, S.
    Chen, B.
    Rookus, M. A.
    Schmidt, M. K.
    van der Baan, F. H.
    Spurdle, A. B.
    Walker, L. C.
    Lose, F.
    Maia, A. T.
    Montagna, M.
    Matricardi, L.
    Lubinski, J.
    Jakubowska, A.
    Gomez Garcia, E. B.
    Olopade, O. I.
    Nussbaum, R. L.
    Nathanson, K. L.
    Domchek, S. M.
    Rebbeck, T. R.
    Arun, B. K.
    Karlan, B. Y.
    Orsulic, S.
    Lester, J.
    Chung, W. K.
    Miron, A.
    Southey, M. C.
    Goldgar, D. E.
    Buys, S. S.
    Janavicius, R.
    Dorfling, C. M.
    van Rensburg, E. J.
    Ding, Y. C.
    Neuhausen, S. L.
    Hansen, T. V.
    Gerdes, A. M.
    Ejlertsen, B.
    Jonson, L.
    Osorio, A.
    Martinez-Bouzas, C.
    Benitez, J.
    Conway, E. E.
    Blazer, K. R.
    Weitzel, J. N.
    Manoukian, S.
    Peissel, B.
    Zaffaroni, D.
    Scuvera, G.
    Barile, M.
    Ficarazzi, F.
    Mariette, F.
    Fortuzzi, S.
    Viel, A.
    Giannini, G.
    Papi, L.
    Martayan, A.
    Tibiletti, M. G.
    Radice, P.
    Vratimos, A.
    Fostira, F.
    Garber, J. E.
    Donaldson, A.
    Brewer, Carole
    Foo, C.
    Evans, D. G.
    Frost, D.
    Eccles, D.
    Brady, A.
    Cook, J.
    Tischkowitz, M.
    Adlard, J.
    Barwell, J.
    Walker, L.
    Izatt, L.
    Side, L. E.
    Kennedy, M. J.
    Rogers, M. T.
    Porteous, M. E.
    Morrison, P. J.
    Platte, R.
    Davidson, R.
    Hodgson, S. V.
    Ellis, S.
    Cole, T.
    Embrace,
    Godwin, A. K.
    Claes, K.
    Van Maerken, T.
    Meindl, A.
    Gehrig, A.
    Sutter, C.
    Engel, C.
    Niederacher, D.
    Steinemann, D.
    Plendl, H.
    Kast, K.
    Rhiem, K.
    Ditsch, N.
    Arnold, N.
    Varon-Mateeva, R.
    Wappenschmidt, B.
    Wang-Gohrke, S.
    Bressac-de Paillerets, B.
    Buecher, B.
    Delnatte, C.
    Houdayer, C.
    Stoppa-Lyonnet, D.
    Damiola, F.
    Coupier, I.
    Barjhoux, L.
    Venat-Bouvet, L.
    Golmard, L.
    Boutry-Kryza, N.
    Sinilnikova, O. M.
    Caron, O.
    Pujol, P.
    Mazoyer, S.
    Belotti, M.
    Gemo Study Collaborators
    Piedmonte, M.
    Friedlander, M. L.
    Rodriguez, G. C.
    Copeland, L. J.
    de la Hoya, M.
    Segura, P. P.
    Nevanlinna, H.
    Aittomaki, K.
    van Os, T. A.
    Meijers-Heijboer, H. E.
    van der Hout, A. H.
    Vreeswijk, M. P.
    Hoogerbrugge, N.
    Ausems, M. G.
    van Doorn, H. C.
    Collee, J. M.
    Hebon,
    Olah, E.
    Diez, O.
    Blanco, I.
    Lazaro, C.
    Brunet, J.
    Feliubadalo, L.
    Cybulski, C.
    Gronwald, J.
    Durda, K.
    Jaworska-Bieniek, K.
    Sukiennicki, G.
    Arason, A.
    Chiquette, J.
    Teixeira, M. R.
    Olswold, C.
    Couch, F. J.
    Lindor, N. M.
    Wang, X.
    Szabo, C. I.
    Offit, K.
    Corines, M.
    Jacobs, L.
    Robson, M. E.
    Zhang, L.
    Joseph, V.
    Berger, A.
    Singer, C. F.
    Rappaport, C.
    Kaulich, D. G.
    Pfeiler, G.
    Tea, M. K.
    Phelan, C. M.
    Greene, M. H.
    Mai, P. L.
    Rennert, G.
    Mulligan, A. M.
    Glendon, G.
    Tchatchou, S.
    Andrulis, I. L.
    Toland, A. E.
    Bojesen, A.
    Pedersen, I. S.
    Thomassen, M.
    Jensen, U. B.
    Laitman, Y.
    Rantala, J.
    von Wachenfeldt, A.
    Ehrencrona, H.
    Askmalm, M. S.
    Borg, A.
    Kuchenbaecker, K. B.
    McGuffog, L.
    Barrowdale, D.
    Healey, S.
    Lee, A.
    Pharoah, P. D.
    Chenevix-Trench, G.
    K. ConFab Investigators
    Antoniou, A. C.
    Friedman, E.
    Date
    2015-01-01
    Journal
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
    Type
    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.
    Publisher
    Cancer Epidemiol Biomarkers Prev
    DOI
    10.1158/1055-9965.EPI-14-0532
    Metadata
    Show full item record
    Abstract
    BACKGROUND: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes. METHODS: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach. RESULTS: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments. CONCLUSION: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers. IMPACT: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies.
    Citation
    Cancer Epidemiol Biomarkers Prev. 2015 Jan;24(1):308-16.
    Publisher URL
    http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=25336561
    Note
    This article is available via Open Access. Please click on the 'Additional Link' above to access the full-text.
    Collections
    • 2015 RD&E publications
    • Clinical Genetics (Peninsula Genetics)

    Browse

    All of RD&E Research RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2021  DuraSpace
    Contact Us | Send Feedback
    DSpace Express is a service operated by 
    Atmire NV