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    Afatinib use in non-small cell lung cancer previously sensitive to epidermal growth factor receptor inhibitors: the United Kingdom Named Patient Programme

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    URI
    http://hdl.handle.net/11287/593859
    Author
    Khan, F.
    Ottensmeier, C.
    Popat, S.
    Dua, D.
    Dorey, Nicole
    Ellis, S.
    Szabo, M.
    Upadhyay, S.
    Califano, R.
    Chan, S.
    Lee, L.
    Ali, C. W.
    Nicolson, M.
    Bates, A. T.
    Button, M.
    Chaudhuri, A.
    Mulvenna, P.
    Shaw, H. M.
    Danson, S. J.
    Date
    2014-07-01
    Journal
    European journal of cancer
    Type
    Journal Article
    Multicenter Study
    Publisher
    Elsevier
    DOI
    10.1016/j.ejca.2014.03.001
    Metadata
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    Abstract
    INTRODUCTION: Afatinib prolongs progression-free survival (PFS) in patients with non-small cell lung cancer (NSCLC) who were previously sensitive to erlotinib or gefitinib. This study investigated experience of afatinib under a Named Patient Use (NPU) programme. PATIENTS AND METHODS: Retrospective data for 63 patients were collected, including demographics, dose, toxicity and clinical efficacy. RESULTS: Response rate and median PFS were 14.3% and 2.6months, respectively. Diarrhoea and rash were the most common toxicities; 46% of patients required a dose reduction and 41% had a dose delay. CONCLUSIONS: Efficacy and safety in the NPU programme are consistent with the LUX-Lung 1 trial.
    Citation
    Eur J Cancer. 2014 Jul;50(10):1717-21.
    Publisher URL
    http://linkinghub.elsevier.com/retrieve/pii/S0959-8049(14)00222-6
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