• Login
    View Item 
    •   Royal Devon Research Repository Home
    • All RD&E publications by year
    • 2014 RD&E publications
    • View Item
    •   Royal Devon Research Repository Home
    • All RD&E publications by year
    • 2014 RD&E publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    A randomized trial comparing treatments for varicose veins

    Thumbnail
    URI
    http://hdl.handle.net/11287/593809
    Author
    Brittenden, J.
    Cotton, S. C.
    Elders, A.
    Ramsay, C. R.
    Norrie, J.
    Burr, J.
    Campbell, Bruce
    Bachoo, P.
    Chetter, I.
    Gough, M.
    Earnshaw, J.
    Lees, T.
    Scott, J.
    Baker, S. A.
    Francis, J.
    Tassie, E.
    Scotland, G.
    Wileman, S.
    Campbell, M. K.
    Date
    2014-09-25
    Journal
    The New England journal of medicine
    Type
    Journal Article
    Comparative Study
    Multicenter Study
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't
    Publisher
    NEJM
    DOI
    10.1056/NEJMoa1400781
    Metadata
    Show full item record
    Abstract
    BACKGROUND: Ultrasound-guided foam sclerotherapy and endovenous laser ablation are widely used alternatives to surgery for the treatment of varicose veins, but their comparative effectiveness and safety remain uncertain. METHODS: In a randomized trial involving 798 participants with primary varicose veins at 11 centers in the United Kingdom, we compared the outcomes of foam, laser, and surgical treatments. Primary outcomes at 6 months were disease-specific quality of life and generic quality of life, as measured on several scales. Secondary outcomes included complications and measures of clinical success. RESULTS: After adjustment for baseline scores and other covariates, the mean disease-specific quality of life was slightly worse after treatment with foam than after surgery (P=0.006) but was similar in the laser and surgery groups. There were no significant differences between the surgery group and the foam or the laser group in measures of generic quality of life. The frequency of procedural complications was similar in the foam group (6%) and the surgery group (7%) but was lower in the laser group (1%) than in the surgery group (P<0.001); the frequency of serious adverse events (approximately 3%) was similar among the groups. Measures of clinical success were similar among the groups, but successful ablation of the main trunks of the saphenous vein was less common in the foam group than in the surgery group (P<0.001). CONCLUSIONS: Quality-of-life measures were generally similar among the study groups, with the exception of a slightly worse disease-specific quality of life in the foam group than in the surgery group. All treatments had similar clinical efficacy, but complications were less frequent after laser treatment and ablation rates were lower after foam treatment. (Funded by the Health Technology Assessment Programme of the National Institute for Health Research; Current Controlled Trials number, ISRCTN51995477.).
    Citation
    N Engl J Med. 2014 Sep 25;371(13):1218-27.
    Publisher URL
    http://www.nejm.org/doi/abs/10.1056/NEJMoa1400781?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dwww.ncbi.nlm.nih.gov
    Note
    This article is available via Open Access. Please click on the 'Additional Link' above to access the full-text.
    Collections
    • 2014 RD&E publications
    • Vascular Surgery

    Browse

    All of Royal Devon Research RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2023  DuraSpace
    Contact Us | Send Feedback
    DSpace Express is a service operated by 
    Atmire NV