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    Factors determining penetrance in familial atypical haemolytic uraemic syndrome

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    URI
    http://hdl.handle.net/11287/593804
    Author
    Sansbury, Francis H.
    Cordell, H. J.
    Bingham, Coralie
    Bromilow, Gilly
    Nicholls, Anthony
    Powell, Roy
    Shields, Beverley M
    Smyth, Lucy
    Warwicker, P.
    Strain, L.
    Wilson, V.
    Goodship, J. A.
    Goodship, T. H.
    Turnpenny, Peter D.
    Date
    2014-11-01
    Journal
    Journal of medical genetics
    Type
    Journal Article
    Research Support, Non-U.S. Gov't
    Publisher
    BMJ
    DOI
    10.1136/jmedgenet-2014-102498
    Metadata
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    Abstract
    BACKGROUND: Inherited abnormalities of complement are found in approximately 60% of patients with atypical haemolytic uraemic syndrome (aHUS). Such abnormalities are not fully penetrant. In this study, we have estimated the penetrance of the disease in three families with a CFH mutation (c.3643C>G; p. Arg1215Gly) in whom a common lineage is probable. 25 individuals have been affected with aHUS with three peaks of incidence-early childhood (n=6), early adulthood (n=11) and late adulthood (n=8). Eighteen individuals who have not developed aHUS carry the mutation. METHODS: We estimated penetrance at the ages of 4, 27, 60 and 70 years as both a binary and a survival trait using MLINK and Mendel. We genotyped susceptibility factors in CFH, CD46 and CFHR1 in affected and unaffected carriers. RESULTS AND CONCLUSIONS: We found that the estimates of penetrance at the age of 4 years ranged from <0.01 to 0.10, at the age of 27 years from 0.16 to 0.29, at the age of 60 years from 0.39 to 0.51 and at the age of 70 years from 0.44 to 0.64. We found that the CFH haplotype on the allele not carrying the CFH mutation had a significant effect on disease penetrance. In this family, we did not find that the CD46 haplotypes had a significant effect on penetrance.
    Citation
    J Med Genet. 2014 Nov;51(11):756-64.
    Publisher URL
    http://jmg.bmj.com/cgi/pmidlookup?view=long&pmid=25261570
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