Browsing 2016 RD&E publications by Title
Now showing items 1-20 of 412
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Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.
(Nature, 2016-05-10)Oral squamous cell carcinoma (OSCC) is a lethal disease with a 5-year mortality rate of around 50%. Molecular targeted therapies are not in routine use and novel therapeutic targets are required. Our previous microarray ... -
Abstract 150: Complications and Outcomes of Thrombolysis in Stroke Patients Aged 90 and Over: UK National Registry Data
(American Stroke Association, 2016-02) -
Abstract 152: Complications and Outcomes From Thrombolysis in Stroke Patients With Significant Pre-stroke Disability: Data From the UK National Stroke Registry
(American Stroke Association, 2016-02) -
Abstract TP178: Relationship Between Deprivation and Outcome for Stroke Patients: Data From the UK National Stroke Registry
(American Heart Association, 2016-02-01) -
Acinetobacter baumannii-The New MRSA?
(Eplasty, 2016-03-12) -
Adherence to Oral Glucose-Lowering Therapies and Associations With 1-Year HbA1c: A Retrospective Cohort Analysis in a Large Primary Care Database.
(American Diabetes Association, 2016-02)The impact of taking oral glucose-lowering medicines intermittently, rather than as recommended, is unclear. We conducted a retrospective cohort study using community-acquired U.K. clinical data (Clinical Practice Research ... -
Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model.
(Elsevier, 2016-02-06)Epigenetic disruption has been implicated in many diseases of aging, and age-associated DNA methylation changes at specific genomic loci in humans are strongly correlated with chronological age. The aim of this study was ... -
AIP mutations in young patients with acromegaly and the Tampico Giant: the Mexican experience.
(Springer, 2016-03-31)Although aryl hydrocarbon receptor-interacting protein (AIP) mutations are rare in sporadic acromegaly, their prevalence among young patients is nonnegligible. The objectives of this study were to evaluate the frequency ... -
Allergy in total knee arthroplasty: a review of the facts.
(British Editorial Society of Bone and Joint Journal, 2016-04)We explored the literature surrounding whether allergy and hypersensitivity has a clinical basis for implant selection in total knee arthroplasty (TKA). In error, the terms hypersensitivity and allergy are often used ... -
The Alpha-Defensin Immunoassay and Leukocyte Esterase Colorimetric Strip Test for the Diagnosis of Periprosthetic Infection: A Systematic Review and Meta-Analysis.
(Journal of Bone & Joint Surgery, 2016-06-15)Synovial biomarkers have recently been adopted as diagnostic tools for periprosthetic joint infection (PJI), but their utility is uncertain. The purpose of this systematic review and meta-analysis was to synthesize the ... -
Alternative technique in atypical spinal decompression: the use of the ultrasonic scalpel in paediatric achondroplasia.
(BMJ, 2016-06-10)Spinal stenosis can be a very disabling condition. Surgical decompression carries a risk of dural tear and neural injury, which is increased in patients with severe stenosis or an atypical anatomy. We present an unusual ... -
Anaesthetising the malnourished patient
(World Federation of Societies of Anaesthesiologists, 2016-06) -
Anatomic Anterior Cruciate Ligament Reconstruction: The Use of the Anterior Horn of the Lateral Meniscus as a Guide to Tibial Tunnel Placement
(Elsevier, 2016-08-01)Anatomic anterior cruciate ligament reconstruction has been shown to reduce the risk of graft failure and to improve patient-related clinical outcomes. The posterior border of the anterior horn of the lateral meniscus is ... -
Anatomy of the terminal branch of the posterior circumflex humeral artery: relevance to the deltopectoral approach to the shoulder.
(British Editorial Society of Bone and Joint Journal, 2016-10)Despite the expansion of arthroscopic surgery of the shoulder, the open deltopectoral approach is increasingly used for the fixation of fractures and arthroplasty of the shoulder. The anatomy of the terminal branches of ... -
Anterior cruciate ligament reconstruction with 70° arthroscope and flexible reamers – Early operative experience
(Elsevier, 2016-07-13)Anatomical graft position for anterior cruciate ligament (ACL) reconstruction is desirable. However, visualisation and positioning are challenges with the standard technique. It is known that graft integration can be ... -
The anterolateral ligament of the knee: unwrapping the enigma. Anatomical study and comparison to previous reports.
(Springer, 2016-02-09)It has been suggested that the anterolateral ligament (ALL) of the knee may have importance in limiting rotational instability, and reconstruction may prevent a continued pivot-shift following anterior cruciate ligament ... -
Assessing the effectiveness of enhanced psychological care for patients with depressive symptoms attending cardiac rehabilitation compared with treatment as usual (CADENCE): study protocol for a pilot cluster randomised controlled trial.
(BioMed Central, 2016-02-02)Around 17 % of people eligible for UK cardiac rehabilitation programmes following an acute coronary syndrome report moderate or severe depressive symptoms. While maximising psychological health is a core goal of cardiac ...