• Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults 

  Hannon, Eilis; Mill, Jonathan (Elsevier Science, 2019-10-15)

  Background: Previous studies have reported associations between attention-deficit/hyperactivity disorder symptoms and DNA methylation in children. We report the first epigenome-wide association study meta-analysis of adult ...

• Interventions to improve the mental health of children and young people with long-term physical conditions: linked evidence syntheses 

  Moore, D. A.; Nunns, M.; Rogers, M.; Ford, T.; Garside, R.; Ukoumunne, O. C.; Anderson, R.; Dickens, C.; Logan, Stuart; Thompson Coon, J. (NIHR Journals Library, 2019-05)

  Background: Although mental health difficulties can severely complicate the lives of children and young people (CYP) with long-term physical conditions (LTCs), there is a lack of evidence about the effectiveness of ...

• Drug repositioning and repurposing for Alzheimer disease 

  Ballard, Clive; Corbett, Anne (Nature Publishing Group, 2020-12)

  Drug repositioning and repurposing can enhance traditional drug development efforts and could accelerate the identification of new treatments for individuals with Alzheimer disease (AD) dementia and mild cognitive impairment. ...

• Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity 

  Wood, Andrew R; Jones, A. G.; Frayling, Timothy M. (Silverchair Information Systems, 2021-01-01)

  Context: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, ...

• Potentially inappropriate prescribing in dementia, multi-morbidity and incidence of adverse health outcomes 

  Ballard, Clive; Melzer, David; Jones, Lindsay; Delgado, J. (Oxford University Press, 2021-02-26)

  Importance: treatment of dementia in individuals with comorbidities is complex, leading to potentially inappropriate prescribing (PIP). The impact of PIP in this population is unknown. Objective: to estimate the rate ...

• International relevance of two measures of awareness of age-related change (AARC) 

  Ballard, Clive; Ukoumunne, O. C.; Corbett, Anne (BioMed Central, 2020-09-21)

  Background: A questionnaire assessing awareness of positive and negative age-related changes (AARC gains and losses) was developed in the US and Germany. We validated the short form of the measure (AARC-10 SF) and the ...

• The Incidence of Recorded Delirium Episodes Before and After Dementia Diagnosis: Differences Between Dementia With Lewy Bodies and Alzheimer's Disease 

  Ballard, Clive (Elsevier Science, 2019-05)

  Objectives: To describe the incidence of delirium recording before and after a diagnosis of dementia is established in patients with dementia with Lewy bodies (DLB) and compare findings to a matched cohort of patients with ...

• Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants 

  Pilling, L. C.; Melzer, David (Wiley, 2019-12)

  Inherited genetic variation influencing leukocyte telomere length provides a natural experiment for testing associations with health outcomes, more robust to confounding and reverse causation than observational studies. ...

• Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis 

  Smith, Adam R.; Lunnon, Katie (BioMed Central, 2020-09-11)

  Background: Mitochondrial dysregulation and aberrant epigenetic mechanisms have been frequently reported in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and several researchers suggested that ...

• Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia 

  Mill, Jonathan (HighWire, 2020-07-31)

  Altered olfactory function is a common symptom of COVID-19, but its etiology is unknown. A key question is whether SARS-CoV-2 (CoV-2) - the causal agent in COVID-19 - affects olfaction directly, by infecting olfactory ...

• The impact of the World Health Organization Health Promoting Schools framework approach on diet and physical activity behaviours of adolescents in secondary schools: a systematic review 

  McHugh, C.; Hurst, A.; Bethel, A.; Lloyd, J.; Logan, S.; Wyatt, K. (Elsevier Science, 2020-05)

  Objective: To examine the effectiveness of interventions using the World Health Organization Health Promoting Schools (HPSs) framework approach in increasing physical activity (PA) and improving the diet of 11-18-year-ol ...

• Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement 

  Hannon, Eilis; Mill, Jonathan (Elsevier Science, 2020-05-08)

  DNA methylation plays an important role in both normal human development and risk of disease. The most utilized method of assessing DNA methylation uses BeadChips, generating an epigenome-wide "snapshot" of >450,000 ...

• Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity 

  Yaghootkar, Hanieh; Frayling, Timothy M. (HighWire, 2020-12)

  Leptin influences food intake by informing the brain about the status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated by administering ...

• Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt-Jakob disease 

  Smith, Adam R.; Smith, R. G.; Lunnon, Katie (Springer, 2020-12)

  Prion diseases are fatal and transmissible neurodegenerative disorders caused by the misfolding and aggregation of prion protein. Although recent studies have implicated epigenetic variation in common neurodegenerative ...

• From Biology to Genes and Back Again: Gene Discovery for Monogenic Forms of Beta-Cell Dysfunction in Diabetes 

  De Franco, Elisa (Elsevier Science, 2020-03-06)

  This review focuses on gene discovery strategies used to identify monogenic forms of diabetes caused by reduced pancreatic beta-cell number (due to destruction or defective development) or impaired beta-cell function. Gene ...

• Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults 

  Creese, Byron; Corbett, Anne; Ballard, Clive (Elsevier Science, 2019-08)

  Objective: Mild behavioral impairment (MBI) is a neurobehavioral syndrome characterized by later life emergent neuropsychiatric symptoms (NPS) that represent an at-risk state for incident cognitive decline and dementia in ...

• Refinement of the critical genomic region for congenital hyperinsulinism in the Chromosome 9p deletion syndrome 

  Laver, T. W.; Caswell, R.; Wakeling, M. N.; Weedon, M. N.; Ellard, Sian; Flanagan, Sarah (Wellcome Open Research, 2020-08-04)

  Background: Large contiguous gene deletions at the distal end of the short arm of chromosome 9 result in the complex multi-organ condition chromosome 9p deletion syndrome. A range of clinical features can result from these ...

• Whole transcriptome in silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side effects 

  Mill, Jonathan; Ballard, Clive; Jeffries, A. R.; Creese, Byron (Wiley-Blackwell, 2020-08-24)

  Background: Stroke/thromboembolic events, infections, and death are all significantly increased by antipsychotics in dementia but little is known about why they can be harmful. Using a novel application of a drug repurposing ...

• Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection 

  Morgan, Noel; Richardson, S. J. (Multidisciplinary Digital Publishing Institue, 2020-09-15)

  Enteroviruses (EVs) have long been implicated in the pathogenesis of type 1 diabetes (T1D), and accumulating evidence has associated virus-induced autoimmunity with the loss of pancreatic beta cells in T1D. Inflammatory ...

• Ruxolitinib Controls Lymphoproliferation and Diabetes in a STAT3-GOF Patient 

  Johnson, M. B. (Springer, 2020-11)

  This article is available to RD&E staff via NHS OpenAthens. Click on the Publisher URL, and log in with NHS OpenAthens if prompted.

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