• PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction. 

  Colli, M. L.; Hill, J. L. E.; Marroquí, L.; Chaffey, J.; Dos Santos, R. S.; Leete, P.; Coomans de Brachène, A.; Paula, F. M. M.; Op de Beeck, A.; Castela, A.; Marselli, L.; Krogvold, L.; Dahl-Jorgensen, K.; Marchetti, P.; Morgan, Noel; Richardson, S. J.; Eizirik, D. L. (Elsevier, 2018-09-27)

  Antibodies targeting PD-1 and its ligand PDL1 are used in cancer immunotherapy but may lead to autoimmune diseases, including type 1 diabetes (T1D). It remains unclear whether PDL1 is expressed in pancreatic islets of ...

• Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made. 

  Morgan, Noel; Richardson, S. J. (Springer, 2018-09-25)

  Type 1 diabetes is increasing in incidence in many parts of the world and it might be imagined that the pathological processes that underlie disease progression are firmly understood. However, this is not the case; rather, ...

• Novel mutations in ALDH1A3 associated with autosomal recessive anophthalmia/microphthalmia, and review of the literature. 

  Lin, S.; Harlalka, G. V.; Hameed, A.; Reham, H. M.; Yasin, M.; Muhammad, N.; Khan, S.; Baple, E. L.; Crosby, Andrew H.; Saleha, S. (BioMed Central, 2018-09-10)

  Autosomal recessive anophthalmia and microphthalmia are rare developmental eye defects occurring during early fetal development. Syndromic and non-syndromic forms of anophthalmia and microphthalmia demonstrate extensive ...

• Discrimination of skin cancer cells using Fourier transform infrared spectroscopy. 

  Peñaranda, F.; Naranjo, V.; Lloyd, G. R.; Kastl, L.; Kemper, B.; Schnekenburger, J.; Nallala, J.; Stone, Nick (Elsevier, 2018-09-01)

  Fourier transform infrared (FTIR) spectroscopy is a highly versatile tool for cell and tissue analysis. Modern commercial FTIR microspectroscopes allow the acquisition of good-quality hyperspectral images from cytopathological ...

• The effectiveness and cost-effectiveness of the Incredible Years® Teacher Classroom Management programme in primary school children: results of the STARS cluster randomised controlled trial. 

  Ford, T.; Hayes, R.; Byford, S.; Edwards, V.; Fletcher, M.; Logan, Stuart; Norwich, B.; Pritchard, W.; Allen, K.; Allwood, M.; Ganguli, P.; Grimes, K.; Hansford, L.; Longdon, B.; Norman, S.; Price, A.; Ukoumunne, O. C. (Cambridge Journals, 2018-07-18)

  We evaluated the effectiveness and cost-effectiveness of the Incredible Years® Teacher Classroom Management (TCM) programme as a universal intervention, given schools' important influence on child mental health.

• Sex-specific transcription and DNA methylation profiles of reproductive and epigenetic associated genes in the gonads and livers of breeding zebrafish. 

  Laing, L. V.; Viana, J.; Dempster, E. L.; Uren Webster, T. M.; van Aerle, R.; Mill, Jonathan; Santos, E M (Elsevier, 2018-08)

  Reproduction is an essential process for life and is regulated by complex hormone networks and environmental factors. To date, little is known about the contribution of epigenetic mechanisms to the regulation of reproduction, ...

• Prenatal immune activation alters the adult neural epigenome but can be partly stabilised by a n-3 polyunsaturated fatty acid diet. 

  Basil, P.; Li, Q.; Gui, H.; Hui, T. C. K.; Ling, V. H. M.; Wong, C. C. Y.; Mill, Jonathan; McAlonan, G. M.; Sham, P-C (Nature, 2018-07-02)

  An unstable epigenome is implicated in the pathophysiology of neurodevelopmental disorders such as schizophrenia and autism. This is important because the epigenome is potentially modifiable. We have previously reported ...

• Peripheral DNA methylation, cognitive decline and brain aging: pilot findings from the Whitehall II imaging study. 

  Chouliaras, L.; Mill, Jonathan (Future Medicine, 2018-05)

  The present study investigated the link between peripheral DNA methylation (DNAm), cognitive impairment and brain aging.

• Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression 

  Wray, N. R. [et al]; Mill, Jonathan (Nature, 2018-05)

  Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and ...

• Clinical exome sequencing reveals locus heterogeneity and phenotypic variability of cohesinopathies. 

  Yuan, B. [et al]; Baple, Emma L.; Rawlins, Lettie; Crosby, Andrew H. (Nature, 2018-08-30)

  Defects in the cohesin pathway are associated with cohesinopathies, notably Cornelia de Lange syndrome (CdLS). We aimed to delineate pathogenic variants in known and candidate cohesinopathy genes from a clinical exome perspective.

• Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa. 

  Li, L. [et al]; Baple, Emma L.; Crosby, Andrew H.; Fasham, James (PLoS, 2018-08)

  We identified a homozygous missense alteration (c.75C>A, p.D25E) in CLCC1, encoding a presumptive intracellular chloride channel highly expressed in the retina, associated with autosomal recessive retinitis pigmentosa ...

• Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention. 

  Richardson, S. J.; Morgan, Noel (Elsevier, 2018-07-28)

  The development of islet autoimmunity and type 1 diabetes has long been linked with enteroviral infection but a causal relationship has proven hard to establish. This is partly because much of the epidemiological evidence ...

• Genome-wide methylomic analysis in individuals with HNF1B intragenic mutation and 17q12 microdeletion. 

  Clissold, Rhian L.; Ashfield, B.; Burrage, J.; Hannon, E.; Bingham, Coralie; Mill, Jonathan; Hattersley, Andrew T.; Dempster, E. L. (BioMed Central, 2018-07-18)

  Heterozygous mutation of the transcription factor HNF1B is the most common cause of monogenetic developmental renal disease. Disease-associated mutations fall into two categories: HNF1B intragenic mutations and a 1.3 Mb ...

• Recurrent Abdominal Pain in Children: Summary Evidence From 3 Systematic Reviews of Treatment Effectiveness. 

  Abbott, R. A.; Martin, A. E.; Newlove-Delgado, T. V.; Bethel, A.; Whear, R. S.; Thompson Coon, J.; Logan, Stuart (Wolters Kluwer, 2018-07)

  Between 4% and 25% of school-aged children complain of recurrent abdominal pain (RAP) severe enough to interfere with their daily activities.

• Interventions for reducing unplanned paediatric admissions: an observational study in one hospital. 

  Husk, K.; Berry, V.; Tozer, R.; Skipwith, G.; Radmore, R.; Ball, S.; Ukoumunne, O. C.; Logan, Stuart (BMJ, 2018-03)

  Evidence on how best to intervene to improve paediatric acute care and therefore reduce unplanned hospital admissions is weak. We describe service evaluation work at one hospital to assess interventions at critical clinical ...

• Effectiveness of nonpharmacological interventions to reduce procedural anxiety in children and adolescents undergoing treatment for cancer: A systematic review and meta-analysis. 

  Nunns, M.; Mayhew, D.; Ford, T. J.; Rogers, M.; Curle, C.; Logan, Stuart; Moore, D. (Wiley, 2018-04-30)

  Children and young people (CYP) with cancer undergo painful and distressing procedures. We aimed to systematically review the effectiveness of nonpharmacological interventions to reduce procedural anxiety in CYP.

• Assessment of Compressive Raman versus Hyperspectral Raman for Microcalcification Chemical Imaging 

  Scotté, C.; de Aguiar, H. B.; Marguet, D.; Green, E. M.; Bouzy, P.; Vergnole, S.; Winlove, C. P.; Stone, Nick; Rigneault, H. (American Chemical Society, 2018-05-15)

• Mid-infrared multispectral tissue imaging using a chalcogenide fiber supercontinuum source. 

  Petersen, C. R.; Prtljaga, N.; Farries, M.; Ward, J.; Napier, B.; Lloyd, G. R.; Nallala, J.; Stone, Nick; Bang, O. (Optical Society, 2018-03-01)

  We present, to the best of our knowledge, the first demonstration of mid-infrared supercontinuum (SC) tissue imaging at wavelengths beyond 5 μm using a fiber-coupled SC source spanning 2-7.5 μm. The SC was generated in a ...

• Mid-IR hyperspectral imaging for label-free histopathology and cytology 

  Hermes, M; Morrish, R Brandstrup; Huot, L; Meng, L; Junaid, S; Tomko, J; Lloyd, G R; Masselink, W T; Tidemand-Lichtenberg, P; Pedersen, C; Palombo, F; Stone, Nick (IOP, 2018-05-08)

• Clinical applications of infrared and Raman spectroscopy: state of play and future challenges. 

  Baker, M. J. [et al[ inc.; Stone, Nick (Royal Society of Chemistry, 2018-04-16)

  Vibrational spectroscopies, based on infrared absorption and/or Raman scattering provide a detailed fingerprint of a material, based on the chemical content. Diagnostic and prognostic tools based on these technologies have ...

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