Research outputs from the Oncology department at the RD&E.

Recent Submissions

  • Artificial intelligence - can it be used to outsmart oral cancer? 

    Baniulyte, G.; Ali, K. (Springer Nature, 2022-03-01)
    Data Sources Electronic search on PubMed, Cochrane, Scopus, Embase, Google Scholar, Saudi Digital Library and Web of Science, and hand searching carried out for studies published January 2000-March 2021. Language was ...
  • Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis 

    Murphy, N.; Song, M.; Papadimitriou, N.; Carreras-Torres, R.; Langenberg, C.; Martin, R. M.; Tsilidis, K. K.; Barroso, I.; Chen, J.; Frayling, T.; Bull, C. J.; Vincent, E. E.; Cotterchio, M.; Gruber, S. B.; Pai, R. K.; Newcomb, P. A.; Perez-Cornago, A.; van Duijnhoven, F. J. B.; Van Guelpen, B.; Vodicka, P.; Wolk, A.; Wu, A. H.; Peters, U.; Chan, A. T.; Gunter, M. J. (Oxford University Press, 2022-01-20)
    BACKGROUND: Glycemic traits-such as hyperinsulinemia, hyperglycemia, and type-2 diabetes-have been associated with higher colorectal cancer risk in observational studies; however, causality of these associations is uncertain. ...
  • British Gynaecological Cancer Society (BGCS) uterine cancer guidelines: Recommendations for practice 

    Morrison, J.; Balega, J.; Buckley, L.; Clamp, A.; Crosbie, E.; Drew, Y.; Durrant, L.; Forrest, J.; Fotopoulou, C.; Gajjar, K.; Ganesan, R.; Gupta, J.; Hughes, J.; Miles, T.; Moss, E.; Nanthakumar, M.; Newton, C.; Ryan, N.; Walther, A.; Taylor, A. (Elsevier, 2021-11-25)
  • Re-evaluating the diagnostic efficacy of PSA as a referral test to detect clinically significant prostate cancer in contemporary MRI-based image-guided biopsy pathways 

    Lophatananon, Artitaya; Light, Alexander; Burns-Cox, Nicholas; Maccormick, Angus; John, Joseph; Otti, Vanessa; McGrath, John; Archer, Pete; Anning, Jonathan; McCracken, Stuart; Page, Toby; Muir, Ken; Gnanapragasam, Vincent J
    Introduction:Modern image-guided biopsy pathways at diagnostic centres have greatly refined the investigations of men referred with suspected prostate cancer. However, the referral criteria from primary care are still based ...
  • Venetoclax with Azacitidine or Low Dose Cytarabine As an Alternative to Intensive Chemotherapy in Fit Adults during the COVID19 Pandemic: Real World Data from the UK National Health Service 

    Othman, Jad; Amer, Mariam; Amofa, Ruebina; Anderson, Laura; Austin, Michael J; Bashford, Alex; Belsham, Edward; Boot, Jesca; Campbell, Victoria Louise; Coats, Thomas; Collins, Angela; Crawley, Charles; Crolla, Francesca; Cross, Joe W; Dalley, Chris; Dang, Raymond; Dennis, Mike; Dhawan, Saniya; Elliott, Johnathon; Galli, Sofia; Gallipoli, Paolo; Hodgson, Katherine; Jain, Manish; Kalkur, Pallavi; Katsomitrou, Vana; Khan, Anjum; Khwaja, Asim; Krishnamurthy, Pramila; Latif, Annie; Laurie, John; Lim, Michael; Loizou, Eleana; Loke, Justin; Mannari, Deepak; Manson, Cara; Marshall, Scott R.; Mobashwera, Behnaz; Murthy, Vidhya; Ochaya, Odong; Orthi, Shahzad; Palanicawandar, Renuka; Pillai, Srinivas; Radzova, Dominika; Rye, Adam; Saunders, Jamie; Smith, Matthew; Taussig, David; Taylor, Tom; Whitmill, Richard; Zhao, Rui; Freeman, Sylvie D; Craddock, Charles; Dillon, Richard
    BackgroundBased on early evidence of a high rate of coronavirus mortality in patients with acute myeloid leukaemia (AML) undergoing intensive chemotherapy (IC), the national health service (NHS) in the United Kingdom ...
  • A nationwide trend away from radical prostatectomy for Gleason Grade Group 1 prostate cancer 

    John, J. B.; Pascoe, J.; Fowler, S.; Walton, T.; Johnson, M.; Challacombe, B.; Dickinson, A. J.; Aning, J.; McGrath, J. S. (Wiley, 2021-11-21)
  • Gilteritinib for Relapsed Acute Myeloid Leukaemia with FLT3 Mutation during the COVID-19 Pandemic: Real World Experience from the UK National Health Service 

    Othman, Jad; Afzal, Usman; Amofa, Ruebina; Austin, Michael J; Bashford, Alex; Belsham, Edward; Byrne, Jennifer; Coats, Thomas; Dang, Raymond; Dennis, Mike; Dhawan, Saniya; Elliot, Johnathon; Francis, Sebastian; Gallipoli, Paolo; Hodgson, Katherine; Kallmeyer, Charlotte; Jain, Manish; Katsomitrou, Vana; Khan, Anjum; Khwaja, Asim; Kolade, Seye; Krishnamurthy, Pramila; Latif, Annie; Laurie, John; Lim, Michael; Loke, Ching Ting; Manson, Cara; Marshall, Scott R.; Mobashwera, Behnaz; Munisamy, Sreetharan; Murray, Duncan; Murthy, Vidhya; Palanicawandar, Renuka; Saunders, Jamie; Smith, Matthew; Smith, Katherine; Sternberg, Alex; Taussig, David; Taylor, Tom; Freeman, Sylvie D; Craddock, Charles; Dillon, Richard
    BackgroundEarly data suggest that patients undergoing salvage chemotherapy for relapsed or refractory (R/R) acute myeloid leukaemia (AML) have poor outcomes if infected with SARS-CoV-2, and nosocomial transmission has been ...
  • The role of astrocytes in brain metastasis at the interface of circulating tumour cells and the blood brain barrier 

    Burn, L.; Gutowski, N.; Whatmore, J.; Giamas, G.; Pranjol, M. Z. I. (Bioscience Research Institute, 2021-09-30)
    Tumour metastasis to the brain is a complex process involving crosstalk between the circulating tumour cells and the blood brain barrier (BBB). Astrocytes, which reside in the abluminal surface of the microvasculature of ...
  • Expectant management of borderline ovarian tumor during pregnancy 

    Iavazzo, C.; Gkegkes, I. D. (Springer, 2021-12-01)
  • Changes in the Management of Patients having Radical Radiotherapy for Lung Cancer during the First Wave of the COVID-19 Pandemic in the UK 

    Banfill, K.; Croxford, W.; Fornacon-Wood, I.; Wicks, K.; Ahmad, S.; Britten, A.; Carson, C.; Dorey, N.; Hatton, M.; Hiley, C.; Thippu Jayaprakash, K.; Jegannathen, A.; Koh, P.; Panakis, N.; Peedell, C.; Pope, A.; Powell, C.; Stilwell, C.; Thomas, B.; Toy, E.; Wood, V.; Yahya, S.; Zhou, S. Y.; Price, G.; Faivre-Finn, C. (Elsevier, 2021-10-28)
    AIMS: In response to the COVID-19 pandemic, guidelines on reduced fractionation for patients treated with curative-intent radiotherapy were published, aimed at reducing the number of hospital attendances and potential ...
  • A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study 

    Bancroft, E. K.; Page, E. C.; Brook, M. N.; Thomas, S.; Taylor, N.; Pope, J.; McHugh, J.; Jones, A. B.; Karlsson, Q.; Merson, S.; Ong, K. R.; Hoffman, J.; Huber, C.; Maehle, L.; Grindedal, E. M.; Stormorken, A.; Evans, D. G.; Rothwell, J.; Lalloo, F.; Brady, A. F.; Bartlett, M.; Snape, K.; Hanson, H.; James, P.; McKinley, J.; Mascarenhas, L.; Syngal, S.; Ukaegbu, C.; Side, L.; Thomas, T.; Barwell, J.; Teixeira, M. R.; Izatt, L.; Suri, M.; Macrae, F. A.; Poplawski, N.; Chen-Shtoyerman, R.; Ahmed, M.; Musgrave, H.; Nicolai, N.; Greenhalgh, L.; Brewer, C.; Pachter, N.; Spigelman, A. D.; Azzabi, A.; Helfand, B. T.; Halliday, D.; Buys, S.; Ramon, Y. Cajal T.; Donaldson, A.; Cooney, K. A.; Harris, M.; McGrath, J.; Davidson, R.; Taylor, A.; Cooke, P.; Myhill, K.; Hogben, M.; Aaronson, N. K.; Ardern-Jones, A.; Bangma, C. H.; Castro, E.; Dearnaley, D.; Dias, A.; Dudderidge, T.; Eccles, D. M.; Green, K.; Eyfjord, J.; Falconer, A.; Foster, C. S.; Gronberg, H.; Hamdy, F. C.; Johannsson, O.; Khoo, V.; Lilja, H.; Lindeman, G. J.; Lubinski, J.; Axcrona, K.; Mikropoulos, C.; Mitra, A. V.; Moynihan, C.; Ni Raghallaigh, H.; Rennert, G.; Collier, R.; Offman, J.; Kote-Jarai, Z.; Eeles, R. A. (Elsevier, 2021-11-01)
    BACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and ...
  • Aromatherapy Massage for Breast Cancer Patients: A Randomized Controlled Trial 

    Anne Clemo-Crosby, Jenny Day Claire Stidston Shannon McGinley Roy John Powell (Gavin Publishers, 43186)
    The aim of this large randomized controlled study was to test the value of Aromatherapy (AM) with breast cancer patients for reducing symptoms, such as pain, anxiety, depression, emotional responses, insomnia, nausea/vomiting ...
  • Comparing pain control and ability to eat and drink with standard therapy vs Gelclair: a preliminary, double centre, randomised controlled trial on patients with radiotherapy-induced oral mucositis 

    Barber, C.; Powell, R.; Ellis, A.; Hewett, J. (Springer, 2006-11-28)
    GOAL OF THE WORK: Oral mucositis (OM) is a functionally destructive complication of aggressive head and neck cancer therapy, often resulting in intense pain, an inability to eat and drink and secondary malnutrition and ...
  • Immunohistochemical detection of p53 and c-erbB-2 in oesophageal carcinoma; no correlation with prognosis 

    Hardwick, R. H.; Barham, C. P.; Ozua, P.; Newcomb, P. V.; Savage, P.; Powell, R.; Rahamin, J.; Alderson, D. (Elsevier, 1997-02-01)
    TNM staging of oesophageal cancer provides significant prognostic information but its clinical impact is limited as many patients present with advanced disease (i.e. T3N1). Additional prognostic markers may help separate ...
  • Association of age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer 

    D'Andrea, D.; Black, P. C.; Zargar, H.; Zargar-Shoshtari, K.; Soria, F.; Fairey, A. S.; Mertens, L. S.; Dinney, C. P.; Mir, M. C.; Krabbe, L. M.; Cookson, M. S.; Jacobsen, N. E.; Montgomery, J. S.; Vasdev, N.; Yu, E. Y.; Xylinas, E.; Campain, N. J.; Kassouf, W.; Dall'Era, M. A.; Seah, J. A.; Ercole, C. E.; Horenblas, S.; Sridhar, S. S.; McGrath, J. S.; Aning, J.; Wright, J. L.; Thorpe, A. C.; Morgan, T. M.; Holzbeierlein, J. M.; Bivalacqua, T. J.; North, S.; Barocas, D. A.; Lotan, Y.; Grivas, P.; Stephenson, A. J.; Shah, J. B.; van Rhijn, B. W.; Daneshmand, S.; Spiess, P. E.; Shariat, S. F. (Springer, 2021-08-09)
    PURPOSE: To assess the association of patient age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer (MIBC). MATERIALS AND METHODS: We analyzed data from 1105 patients with MIBC. ...
  • Nonepithelial ovarian cancers 

    Baker-Rand, Holly; Edey, Katharine (Wiley, 2021-06-07)
    Key content Nonepithelial ovarian cancers (NEOCs) are rare forms of ovarian cancer, including malignant ovarian germ cell tumours (MOGCTs), sex cord-stromal tumours (SCSTs) and ovarian sarcoma. Tumour markers including ...
  • Identifying the Optimal Number of Neoadjuvant Chemotherapy Cycles in Patients with Muscle Invasive Bladder Cancer 

    D'Andrea, D.; Black, P. C.; Zargar, H.; Dinney, C. P.; Soria, F.; Cookson, M. S.; Montgomery, J. S.; Kassouf, W.; Dall'Era, M. A.; Sridhar, S. S.; McGrath, J. S.; Wright, J. L.; Thorpe, A. C.; Holzbeierlein, J. M.; Carrión, D. M.; Di Trapani, E.; Bivalacqua, T. J.; North, S.; Barocas, D. A.; Lotan, Y.; Grivas, P.; Stephenson, A. J.; van Rhijn, B. W.; Daneshmand, S.; Spiess, P. E.; Shariat, S. F. (Lippincott, Williams & Wilkins, 2021-08-27)
    PURPOSE: We investigated the pathological response rates and survival associated with 3 vs 4 cycles of cisplatin-based neoadjuvant chemotherapy (NAC) in patients with cT2-4N0M0 muscle invasive bladder cancer. MATERIALS AND ...
  • Patient perspectives on surveillance after head and neck cancer treatment: A systematic review 

    McLaren, O.; Perkins, C.; Zhu, Y.; Smith, M.; Williams, R. (Wiley, 2021-08-07)
    OBJECTIVES: Current guidelines advise post-treatment surveillance of head and neck cancer (HNC) patients should involve scheduled appointments with a variety of practitioners. Increasing numbers of HNC survivors raise the ...
  • The impact of changing risk thresholds on the number of people in England eligible for urgent investigation for possible cancer: an observational cross-sectional study 

    Moore, S. F.; Price, S. J.; Chowienczyk, S.; Bostock, J.; Hamilton, W. (Nature, 2021-09-16)
    BACKGROUND: Expediting cancer diagnosis may be achieved by targeted decreases in referral thresholds to increase numbers of patients referred for urgent investigation. METHODS: Clinical Practice Research Datalink data from ...

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