Now showing items 1-20 of 135

    • A modified Delphi process to establish research priorities in hernia surgery 

      Scrimgeour, D. S. G.; Allan, M.; Knight, S. R.; East, B.; Blackwell, S.; Dames, N.; Laidlaw, L.; Light, D.; Horgan, L.; Smart, N. J.; de Beaux, A.; Wilson, M. S. J. (Springer, 2021-10-21)
      BACKGROUND: Abdominal wall hernia repair is one of the most commonly performed surgical procedures worldwide, yet despite this, there remains a lack of high-quality evidence to support best management. The aim of the study ...
    • Adalimumab and infliximab impair SARS-CoV-2 antibody responses: results from a therapeutic drug monitoring study in 11422 biologic-treated patients 

      Chanchlani, N.; Lin, S.; Chee, D.; Hamilton, B.; Nice, R.; Zehra, A.; Bewshea, C.; Cipriano, B.; Derikx, Laap; Dunlop, A.; Greathead, L.; Griffiths, R. L.; Ibraheim, H.; Kelleher, P.; Kok, K. B.; Lees, C. W.; MacDonald, J.; Sebastian, S.; Smith, P. J.; McDonald, T. J.; Irving, P. M.; Powell, N.; Kennedy, N. A.; Goodhand, J. R.; Ahmad, T. (Oxford University Press, 2021-09-02)
      BACKGROUND AND AIMS: Infliximab attenuates serological responses to SARS-CoV-2 infection. Whether this is a class effect, or if anti-TNF level influences serological responses, remains unknown. METHODS: Seroprevalence and ...
    • Adaptations to the British Society of Gastroenterology guidelines on the management of acute severe UC in the context of the COVID-19 pandemic: a RAND appropriateness panel 

      Kennedy, Nicholas A. (BMJ, 2020-10)
      Objective: Management of acute severe UC (ASUC) during the novel COVID-19 pandemic presents significant dilemmas. We aimed to provide COVID-19-specific guidance using current British Society of Gastroenterology (BSG) ...
    • Ambulatory care management of 69 patients with acute severe ulcerative colitis in comparison to 695 inpatients: insights from a multicentre UK cohort study 

      Sebastian, S.; Patel, K. V.; Segal, J. P.; Subramanian, S.; Conley, T. E.; Gonzalez, H. A.; Kent, A. J.; Saifuddin, A.; Hicks, L.; Mehta, S.; Bhala, N.; Brookes, M. J.; Lamb, C. A.; Kennedy, N. A.; Walker, G. J. (BMJ Publishing Group, 2022-01-01)
      INTRODUCTION: Acute severe ulcerative colitis (ASUC) traditionally requires inpatient hospital management for intravenous therapies and/or colectomy. Ambulatory ASUC care has not yet been evaluated in large cohorts. AIMS: ...
    • Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab. 

      Kennedy, Nicholas A.; Goodhand, James R.; Bewshea, Claire; Nice, Rachel; Chee, Desmond; Lin, Simeng; Chanchlani, Neil; Butterworth, Jeffrey; Cooney, Rachel; Croft, Nicholas M.; Hart, Ailsa L.; Irving, Peter M.; Kok, Klaartje B.; Lamb, Christopher A.; Limdi, Jimmy K.; Macdonald, Jonathan; McGovern, Dermot Pb; Mehta, Shameer J.; Murray, Charles D.; Patel, Kamal V.; Pollok, Richard Cg; Raine, Timothy; Russell, Richard K.; Selinger, Christian P.; Smith, Philip J.; Bowden, Jack; McDonald, Timothy J.; Lees, Charlie W.; Sebastian, Shaji; Powell, Nicholas; Ahmad, Tariq (BMJ, 2021-05-01)
      OBJECTIVE: Antitumour necrosis factor (anti-TNF) drugs impair protective immunity following pneumococcal, influenza and viral hepatitis vaccination and increase the risk of serious respiratory infections. We sought to ...
    • Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab 

      Lin, S.; Kennedy, N. A.; Saifuddin, A.; Sandoval, D. M.; Reynolds, C. J.; Seoane, R. C.; Kottoor, S. H.; Pieper, F. P.; Lin, K. M.; Butler, D. K.; Chanchlani, N.; Nice, R.; Chee, D.; Bewshea, C.; Janjua, M.; McDonald, T. J.; Sebastian, S.; Alexander, J. L.; Constable, L.; Lee, J. C.; Murray, C. D.; Hart, A. L.; Irving, P. M.; Jones, G. R.; Kok, K. B.; Lamb, C. A.; Lees, C. W.; Altmann, D. M.; Boyton, R. J.; Goodhand, J. R.; Powell, N.; Ahmad, T. (Nature, 2022-03-16)
      Anti tumour necrosis factor (anti-TNF) drugs increase the risk of serious respiratory infection and impair protective immunity following pneumococcal and influenza vaccination. Here we report SARS-CoV-2 vaccine-induced ...
    • An apology for beta blockers 

      Thalheimer, Ulrich; Bosch, J.; Burroughs, A. K. (Elsevier, 2014-08-01)
    • Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study 

      Sebastian, Shaji; Walker, Gareth J.; Kennedy, Nicholas A.; Conley, Thomas E.; Patel, Kamal V.; Subramanian, Sreedhar; Kent, Alexandra J.; Segal, Jonathan P.; Brookes, Matthew J.; Bhala, Neeraj; Gonzalez, Haidee A.; Hicks, Lucy C.; Mehta, Shameer J.; Lamb, Christopher A. (Elsevier, 2021-04-01)
      BACKGROUND: There is a paucity of evidence to support safe and effective management of patients with acute severe ulcerative colitis during the COVID-19 pandemic. We sought to identify alterations to established conventional ...
    • Association between level of fecal calprotectin and progression of Crohn's Disease 

      Kennedy, Nicholas A. (Elsevier, 2019-02-14)
      Mucosal healing is associated with improved outcomes in patients with Crohn’s disease (CD), but assessment typically requires ileocolonoscopy. Calprotectin can be measured in fecal samples to determine luminal disease ...
    • Association of genetic variants in NUDT15 with thiopurine-induced myelosuppression in patients with inflammatory bowel disease 

      Heap, Graham; Walker, Gareth; Todd, Anthony; Bewshea, Claire; Heerasing, Neel; Hendy, Peter; Singh, Abhey (JAMA, 2019-02)
      Use of thiopurines may be limited by myelosuppression. TPMT pharmacogenetic testing identifies only 25% of at-risk patients of European ancestry. Among patients of East Asian ancestry, NUDT15 variants are associated with ...
    • Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis 

      Murphy, N.; Song, M.; Papadimitriou, N.; Carreras-Torres, R.; Langenberg, C.; Martin, R. M.; Tsilidis, K. K.; Barroso, I.; Chen, J.; Frayling, T.; Bull, C. J.; Vincent, E. E.; Cotterchio, M.; Gruber, S. B.; Pai, R. K.; Newcomb, P. A.; Perez-Cornago, A.; van Duijnhoven, F. J. B.; Van Guelpen, B.; Vodicka, P.; Wolk, A.; Wu, A. H.; Peters, U.; Chan, A. T.; Gunter, M. J. (Oxford University Press, 2022-01-20)
      BACKGROUND: Glycemic traits-such as hyperinsulinemia, hyperglycemia, and type-2 diabetes-have been associated with higher colorectal cancer risk in observational studies; however, causality of these associations is uncertain. ...
    • ATU-9 Ambulatory care management of 70 patients with acute severe UC in comparison to 700 inpatients 

      Patel, Kamal; Segal, Jonathan; Sebastian, Shaji; Kent, Alexandra; Hicks, Lucy; Mehta, Shameer; Brookes, Matthew; Lamb, Chris; Kennedy, Nicholas; Walker, Garerth (BMJ, 2021-11-07)
      Introduction Acute severe ulcerative colitis (ASUC) traditionally requires inpatient hospital management for intravenous therapies and/or colectomy. Patients with ASUC can deteriorate rapidly and hence require close ...
    • Beta-blockers in liver cirrhosis 

      Giannelli, V.; Lattanzi, B.; Thalheimer, Ulrich; Merli, M. (Hellenic Society of Gastroenterology, 2014-01-01)
      Since the original description of the effectiveness of beta-blockers in lowering the portal pressure and therefore the risk of variceal bleeding, more than 500 articles in the English literature on the use of non selective ...
    • A blood-based prognostic biomarker in IBD 

      Ahmad, Tariq (BMJ, 2019-08)
      We have previously described a prognostic transcriptional signature in CD8 T cells that separates patients with IBD into two phenotypically distinct subgroups, termed IBD1 and IBD2. Here we sought to develop a blood-based ...
    • British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic 

      Kennedy, Nicholas A. (BMJ, 2020-06)
      The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from China and Italy. In the UK, we have rapidly mobilised inflammatory ...
    • Can Preoperative Characteristics Predict the Outcomes of Laparoscopic Cholecystectomy? 

      Orabi, A.; Di Mauro, D.; Njere, I.; Ratano, M.; Thavakumar, S.; Reece-Smith, A.; Wajed, S.; Manzelli, A. (Mary Ann Liebert, 2021-08-06)
      Background: Intraoperative findings during laparoscopic cholecystectomy (LC) are highly unpredictable and operative difficulty varies from straightforward to very challenging procedures. Several studies described predictors ...
    • Clinical features and genetic risk of demyelination following anti-TNF treatment 

      Lin, Simeng; Hendy, Peter; Heerasing, Neel; Chanchlani, Neil; Hamilton, Benjamin; Walker, Gareth J.; Ahmad, Tariq; Heap, Graham A.; Wood, A. R.; Tyrrell, Jessica; Beaumont, Robin N.; Weedon, M. N.; Kennedy, Nicholas A.; Harrower, Timothy; Goodhand, James R. (Silverchair Information Systems, 2020-06-04)
      Background: Anti-TNF exposure has been linked to demyelination events. We sought to describe the clinical features of demyelination events following anti-TNF treatment and test whether affected patients were genetically ...
    • Clinical features and HLA association of 5-Aminosalicylate (5-ASA) induced nephrotoxicity in inflammatory bowel disease. 

      Heap, Graham A.; So, K; Weedon, M; Edney, Naomi; Bewshea, Claire; Singh, Abhey; Annese, V; Beckly, J; Buurman, D; Chaudhary, R; Cole, A T; Cooper, S C; Creed, T.; Cummings, F; de Boer, N K; D'Inca, R; D'Souza, Richard; Daneshmend, T K; Delaney, M; Dhar, A; Direkze, N; Dunckley, P; Gaya, D R; Gearry, R; Gore, S; Halfvarsson, J; Hart, A; Hawkey, C J; Hoentjen, F; Iqbal, T; Irving, P; Lal, S; Lawrance, I; Lees, C W; Lewis, S; Lockett, M; Mann, S; Mansfield, J; Mowat, C; Mulgrew, Christopher J; Muller, F; Murray, C; Oram, Richard; Orchard, T; Parkes, M; Phillips, R; Pollok, R; Radford-Smith, G; Sebastian, S; Sen, S; Shirazi, T; Silverberg, M; Solomon, L; Sturniolo, G C; Thomas, M; Tremelling, M; Tsianos, E V; Watts, D; Weaver, S; Weersma, R K; Wesley, E; Holden, Ar; Ahmad, Tariq (Oxford University Press, 2015-11-29)
      Background & AimsNephrotoxicity is a rare idiosyncratic reaction to 5-aminosalicylate (5-ASA) therapies. The aims of this study were to describe the clinical features of this complication and identify clinically useful ...
    • Clinician preferences in the treatment of acutely symptomatic hernia: the 'MASH' survey 

      O'Connor, O. M.; Burns, F. A.; Proctor, V. K.; Green, S. K.; Sayers, A. E.; Smart, N. J.; Lee, M. J. (Royal College of Surgeons, 2022-02-23)
      INTRODUCTION: There is limited high-quality evidence to guide the management of acute hernia presentation. The aim of this study was to survey surgeons to assess current trends in assessment, treatment strategy and operative ...
    • Colonic tumour presenting as discrete upper abdominal mass 

      Hamilton, Benjamin; Pang, C. L.; Adlan, Tarig (BMJ, 2015-08-26)