Renal and nephrology services (kidneys)
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Research outputs from the Exeter Kidney Unit (Renal services) at the RD&E.
Recent Submissions
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Even experts cannot agree on the optimal use of platelet-rich plasma in lateral elbow tendinopathy: an international Delphi study
(Springer, 2021-11-25)BACKGROUND: Platelet-rich plasma (PRP) is widely used in the management of lateral elbow tendinopathy (LET) despite conflicting evidence on its effectiveness. With high levels of user experience, this study aimed to assess ... -
Low serum 1,25(OH)2D3 in end stage renal disease - is reduced 1α-hydroxylase the only problem?
(BioScientifica, 2021-09-01)Low serum 1,25-dihydroxyvitamin D (1,25(OH)2D) in end stage renal disease (ESRD) is considered a consequence of elevated fibroblast growth factor 23 (FGF23) and concomitant reduced activity of renal 1α-hydroxylase (CYP27B1). ... -
NIMO-CKD-UK: a real-world, observational study of iron isomaltoside in patients with iron deficiency anaemia and chronic kidney disease.
(BioMed Central, 2020-12-10)BACKGROUND: Intravenous iron is often used to treat iron deficiency anaemia in non-dialysis chronic kidney disease (ND-CKD), but the optimal dosing regimen remains unclear. We evaluated the impact of high- versus low-dose ... -
Contrast-associated acute kidney injury.
(Elsevier, 2020-12-01)Acute kidney injury (AKI) is common, occurring in more than 15% of patients admitted to hospital as an emergency.1 AKI often indicates severe systemic dysfunction and can lead to chronic kidney disease (CKD) and increased ... -
Along came a spider: an unusual organism identified in a peritoneal dialysis patient, a case report and literature review
(Bio Med Central, 2020-11-11)Background: Peritoneal dialysis-associated peritonitis can uncommonly be caused by fungal infections. When they do present, they are associated with significant mortality and morbidity. We describe a case where a sample ... -
IgA Nephropathy Genetic Risk Score to Estimate the Prevalence of IgA Nephropathy in UK Biobank
(Elsevier Science, 2020-07-19)Background: IgA nephropathy (IgAN) is the commonest glomerulonephritis worldwide. Its prevalence is difficult to estimate, as people with mild disease do not commonly receive a biopsy diagnosis. We aimed to generate an IgA ... -
Urinary nitrate concentration as a marker for kidney transplant rejection
(BioMed Central, 2020-10-20)Background: Early identification and treatment of kidney transplant rejection episodes is vital to limit loss of function and prolong the life of the transplanted kidney and recipient. Current practice depends on detecting ... -
Percutaneous microwave ablation of renal masses in a UK cohort
(Wiley, 2020-09-01)Objectives: To report a tertiary referral centre's experience of microwave ablation (MWA) for suspected renal cell carcinoma (RCC), describing complications and oncological outcomes. Patients and methods: Consecutive ... -
Pathogenic germline variants in patients with features of hereditary renal cell carcinoma: Evidence for further locus heterogeneity
(Wiley, 2021-01)Inherited renal cell carcinoma (RCC) is associated with multiple familial cancer syndromes but most individuals with features of non-syndromic inherited RCC do not harbor variants in the most commonly tested renal cancer ... -
An international cohort study of autosomal dominant tubulointerstitial kidney disease due to REN mutations identifies distinct clinical subtypes
(Elsevier Science, 2020-12)There have been few clinical or scientific reports of autosomal dominant tubulointerstitial kidney disease due to REN mutations (ADTKD-REN), limiting characterization. To further study this, we formed an international ... -
Prognostic imaging biomarkers for diabetic kidney disease (iBEAt): study protocol
(BioMed Central, 2020-06-29)Background: Diabetic kidney disease (DKD) remains one of the leading causes of premature death in diabetes. DKD is classified on albuminuria and reduced kidney function (estimated glomerular filtration rate (eGFR)) but ... -
Renal nitrate clearance in chronic kidney disease
(Elsevier Science, 2020-04)Background: Nitric oxide (NO) is rapidly oxidised in humans to nitrite and nitrate, with nitrate being present in much greater abundance. These oxidation products can be recycled back into nitric oxide via a complex ... -
The systemic microcirculation in dialysis populations
(Wiley, 2020-02-17)In a rapidly expanding population of patients with chronic kidney disease, including 2 million people requiring renal replacement therapy, cardiovascular mortality is 15 times greater than the general population. In addition ... -
Introducing the endotype concept to address the challenge of disease heterogeneity in Type 1 diabetes
(American Diabetes Association, 2020-01)The clinical diagnosis of new-onset type 1 diabetes has, for many years, been considered relatively straightforward. Recently, however, there is increasing awareness that within this single clinical phenotype exists ... -
Getting home for haemodialysis: sharing experience to improve the patient experience
(MAG Online Library, 2019-09)Home haemodialysis has many advantages when compared with conventional in-centre haemodialysis, but its uptake remains lower than predicted. This article explores the reasons for this low uptake, and the work of a Special ... -
Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years
(BMJ, 2019-09)OBJECTIVE: To develop and validate multivariable clinical diagnostic models to assist distinguishing between type 1 and type 2 diabetes in adults aged 18-50. DESIGN: Multivariable logistic regression analysis was used ... -
HNF1B mutations are associated with a Gitelman-like tubulopathy that develops during childhood
(Elsevier, 2019-05)Mutations in the transcription factor hepatocyte nuclear factor 1B (HNF1B) are the most common inherited cause of renal malformations, yet also associated with renal tubular dysfunction, most prominently magnesium wasting ... -
Remission of membranous nephropathy after treatment of localised prostate cancer
(Karger, 2019-06)Membranous nephropathy is a cause of the nephrotic syndrome in adults; it can be a primary or secondary process. Secondary causes include solid organ and lymphoid malignancies. Prostate cancer has been reported as the ...
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