Exeter Kidney Unit (Renal)
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Research outputs from the Exeter Kidney Unit (Renal services) at the RD&E.
Recent Submissions
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An international cohort study of autosomal dominant tubulointerstitial kidney disease due to REN mutations identifies distinct clinical subtypes
(Elsevier Science, 2020-12)There have been few clinical or scientific reports of autosomal dominant tubulointerstitial kidney disease due to REN mutations (ADTKD-REN), limiting characterization. To further study this, we formed an international ... -
Prognostic imaging biomarkers for diabetic kidney disease (iBEAt): study protocol
(BioMed Central, 2020-06-29)Background: Diabetic kidney disease (DKD) remains one of the leading causes of premature death in diabetes. DKD is classified on albuminuria and reduced kidney function (estimated glomerular filtration rate (eGFR)) but ... -
Renal nitrate clearance in chronic kidney disease
(Elsevier Science, 2020-04)Background: Nitric oxide (NO) is rapidly oxidised in humans to nitrite and nitrate, with nitrate being present in much greater abundance. These oxidation products can be recycled back into nitric oxide via a complex ... -
The systemic microcirculation in dialysis populations
(Wiley, 2020-02-17)In a rapidly expanding population of patients with chronic kidney disease, including 2 million people requiring renal replacement therapy, cardiovascular mortality is 15 times greater than the general population. In addition ... -
Introducing the endotype concept to address the challenge of disease heterogeneity in Type 1 diabetes
(American Diabetes Association, 2020-01)The clinical diagnosis of new-onset type 1 diabetes has, for many years, been considered relatively straightforward. Recently, however, there is increasing awareness that within this single clinical phenotype exists ... -
Getting home for haemodialysis: sharing experience to improve the patient experience
(MAG Online Library, 2019-09)Home haemodialysis has many advantages when compared with conventional in-centre haemodialysis, but its uptake remains lower than predicted. This article explores the reasons for this low uptake, and the work of a Special ... -
Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years
(BMJ, 2019-09)OBJECTIVE: To develop and validate multivariable clinical diagnostic models to assist distinguishing between type 1 and type 2 diabetes in adults aged 18-50. DESIGN: Multivariable logistic regression analysis was used ... -
HNF1B mutations are associated with a Gitelman-like tubulopathy that develops during childhood
(Elsevier, 2019-05)Mutations in the transcription factor hepatocyte nuclear factor 1B (HNF1B) are the most common inherited cause of renal malformations, yet also associated with renal tubular dysfunction, most prominently magnesium wasting ... -
Remission of membranous nephropathy after treatment of localised prostate cancer
(Karger, 2019-06)Membranous nephropathy is a cause of the nephrotic syndrome in adults; it can be a primary or secondary process. Secondary causes include solid organ and lymphoid malignancies. Prostate cancer has been reported as the ... -
New insights on the genetics of type 1 diabetes
(Wolters Kluwer, 2019-08)The genetic risk for type 1 diabetes has been studied for over half a century, with the strong genetic associations of type 1 diabetes forming critical evidence for the role of the immune system in pathogenesis. In this ... -
Reducing our carbon footprint and resource use on the Exeter Kidney Unit
(2019-07)Conference poster presented at the James Lovelock Centenary conference 'The Future of Global Systems Thinking', University of Exeter, 29th-31st July 2019. -
Renal nurses' lived experiences of discussions about sexuality
(Mark Allen Group, 2019-03)Renal teams focus predominantly on renal replacement therapy and physical symptom management, rather than psychological issues, such as mental health, body image or self-esteem. This study aims to increase understanding ... -
Type 1 diabetes defined by severe insulin deficiency occurs after 30 years of age and is commonly treated as type 2 diabetes
(Springer, 2019-07)Late-onset type 1 diabetes can be difficult to identify. Measurement of endogenous insulin secretion using C-peptide provides a gold standard classification of diabetes type in longstanding diabetes that closely relates ... -
Persistent C-peptide is associated with reduced hypoglycaemia but not HbA1c in adults with longstanding Type 1 diabetes: evidence for lack of intensive treatment in UK clinical practice?
(Wiley, 2019-9)Most people with Type 1 diabetes have low levels of persistent endogenous insulin production. The Diabetes Control and Complications Trial showed that close to diagnosis preserved endogenous insulin was associated with ... -
Up to date on phosphate management and phosphate binders
(Mark Allen Group, 2019-02)Although the cause of hyperphosphatemia remains the same, its management through dietary advice and medication is changing to keep up with the latest evidence. This article discusses some of the recent updates to the KDIGO ... -
Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis.
(American Diabetes Association, 2019-02)Previously generated genetic risk scores (GRSs) for type 1 diabetes (T1D) have not captured all known information at non-HLA loci or, particularly, at HLA risk loci. We aimed to more completely incorporate HLA alleles, ... -
A prospective observational study of iron isomaltoside in haemodialysis patients with chronic kidney disease treated for iron deficiency (DINO).
(BioMed Central, 2019-01-10)Iron deficiency is frequent in haemodialysis (HD) patients with chronic kidney disease (CKD), and intravenous iron is an established therapy for these patients. This study assessed treatment routine, effectiveness, and ... -
Young adults' perspectives on living with kidney failure: a systematic review and thematic synthesis of qualitative studies.
(BMJ, 2018-01)Young adults fare worse than younger adolescents or older adults on a broad range of health indicators. Those with a chronic illness such as renal failure are a particularly vulnerable group, who experience poor outcomes ... -
Genome-wide methylomic analysis in individuals with HNF1B intragenic mutation and 17q12 microdeletion.
(BioMed Central, 2018-07-18)Heterozygous mutation of the transcription factor HNF1B is the most common cause of monogenetic developmental renal disease. Disease-associated mutations fall into two categories: HNF1B intragenic mutations and a 1.3 Mb ...
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