• Morphological and functional cardiac consequences of rapid hypertension treatment: a cohort study 

  Jordan, A. N.; Fulford, J.; Gooding, K.; Anning, C.; Wilkes, L.; Ball, C.; Pamphilon, N.; Mawson, D.; Clark, C. E.; Shore, A. C.; Sharp, A. S. P.; Bellenger, N. G. (BioMed Central, 2021-10-25)

  BACKGROUND: Left ventricular (LV) hypertrophy (LVH) in uncontrolled hypertension is an independent predictor of mortality, though its regression with treatment improves outcomes. Retrospective data suggest that early control ...

• The interarm blood pressure difference as predictor of cardiovascular events in patients with hypertension in primary care: cohort study 

  Clark, C. E.; Campbell, J. L.; Powell, R. J. (Nature, 2007-04-26)

  Objectives of this study were to measure the prevalence of a difference in blood pressure (BP) between arms and determine whether a difference is associated with increased risk of cardiovascular events or death. A prospective ...

• PPA2-associated sudden cardiac death: extending the clinical and allelic spectrum in 20 new families 

  Guimier, A.; Achleitner, M. T.; de Bellaing, A. M.; Edwards, M.; de Pontual, L.; Mittal, K.; Dunn, K. E.; Grove, M. E.; Tysoe, C. J.; Dimartino, C.; Cameron, J.; Kanthi, A.; Shukla, A.; van den Broek, F.; Chatterjee, D.; Alston, C. L.; Knowles, C. V.; Brett, L.; Till, J. A.; Homfray, T.; French, P.; Spentzou, G.; Elserafy, N. A.; Lichkus, K. S.; Sankaran, B. P.; Kennedy, H. L.; George, P. M.; Kidd, A.; Wortmann, S. B.; Fisk, D. G.; Koopmann, T. T.; Rafiq, M. A.; Merker, J. D.; Parikh, S.; Ahimaz, P.; Weintraub, R. G.; Ma, A. S.; Turner, C.; Ellaway, C. J.; Phillips, L. K.; Thorburn, D. R.; Chung, W. K.; Kana, S. L.; Faye-Petersen, O. M.; Thompson, M. L.; Janin, A.; McLeod, K.; McGowan, R.; McFarland, R.; Girisha, K. M.; Morris-Rosendahl, D. J.; Hurst, A. C. E.; Turner, C. L. S.; Hamilton, R. M.; Taylor, R. W.; Bajolle, F.; Gordon, C. T.; Amiel, J.; Mayr, J. A.; Doudney, K. (Nature, 2021-08-16)

  PURPOSE: Biallelic hypomorphic variants in PPA2, encoding the mitochondrial inorganic pyrophosphatase 2 protein, have been recently identified in individuals presenting with sudden cardiac death, occasionally triggered by ...

• Hemicrania continua associated with an unruptured anterior communicating artery aneurysm: first case report 

  Imam, Ibrahim (BMC, 2021-03-08)

• Downstream testing after CT coronary angiography: time for a rethink? 

  Morgan-Hughes, Gareth; Williams, Michelle Claire; Loudon, Margaret; Roobottom, Carl A.; Veitch, Alice; Van Lingen, Robin; Holloway, Ben; Bellenger, Nicholas; Schmitt, Matthias; Bull, Russel (BMJ, 2021-02-01)

  OBJECTIVE: We surveyed UK practice and compliance with the National Institute for Health and Care Excellence (NICE) 'recent-onset chest pain' guidance (Clinical Guideline 95, 2016) as a service quality initiative. We aimed ...

• A New Era in Epicardial Access for the Ablation of Ventricular Arrhythmias: The Epi-Co(2) Registry 

  Juliá, Justo; Bokhari, Fayez; Uuetoa, Hasso; Derejko, Pawel; Traykov, Vassil B.; Gwizdala, Adrian; Sebag, Frederic A.; Hegbom, Finn; Anfinsen, Ole-Gunnar; AlQubbany, Atif; Bardyszewski, Aleksander; Gul, Enes Elvin; Geleva, Valeri; Kirubakaran, Senthil; Podd, Steven; Babu, Girish Ganesha; Balasubramaniam, Richard; Lim, Phang Boon; Wright, Matthew; Veasey, Rick; Mann, Ian; Hildick-Smith, David; McCready, James; Silberbauer, John (JACC, 2021-01-01)

  OBJECTIVES: This multicenter registry aimed to assess the reproducibility and safety of intentional coronary vein exit and carbon dioxide insufflation to facilitate subxiphoid epicardial access in the setting of ventricular ...

• A Rare Finding A Left Atrial Cavernous Haemangioma 

  Gower, Hower; He, Jingzhou; Davies, Timothy; George, Anish (EMJ, 2021-07-01)

• Long Term outcomes of percutaneous atrial fibrillation ablation in patients with continuous monitoring 

  Sulke, N.; Dulai, R.; Freemantle, N.; Sugihara, C.; Podd, S.; Eysenck, W.; Lewis, M.; Hyde, J.; Veasey, R. A.; Furniss, S. S. (Wiley, 2021-06-11)

  INTRODUCTION: There is limited data using continuous monitoring to assess outcomes of atrial fibrillation (AF) ablation. This study assessed long-term outcomes of AF ablation in patients with implantable cardiac devices. ...

• Novel compound heterozygous TTN variants as a cause of severe neonatal congenital contracture syndrome without cardiac involvement diagnosed with rapid trio exome sequencing 

  McDermott, H.; Henderson, A.; Robinson, H. K.; Heaver, R.; Halahakoon, C.; Cox, H.; Naik, S. (Elsevier, 2021-05-24)

  This report focuses on a case of severe congenital myopathy with arthrogryposis without cardiac involvement due to compound heterozygous variants in the TTN gene. The proband presented with severe axial hypotonia, ...

• Associations Between Systolic Interarm Differences in Blood Pressure and Cardiovascular Disease Outcomes and Mortality: Individual Participant Data Meta-Analysis, Development and Validation of a Prognostic Algorithm: The INTERPRESS-IPD Collaboration. 

  Clark, Christopher E.; Warren, Fiona C.; Boddy, Kate; McDonagh, Sinead T. J.; Moore, Sarah F.; Goddard, John; Reed, Nigel; Turner, Malcolm; Alzamora, Maria Teresa; Ramos Blanes, Rafel; Chuang, Shao-Yuan; Criqui, Michael; Dahl, Marie; Engström, Gunnar; Erbel, Raimund; Espeland, Mark; Ferrucci, Luigi; Guerchet, Maëlenn; Hattersley, Andrew; Lahoz, Carlos; McClelland, Robyn L.; McDermott, Mary M.; Price, Jackie; Stoffers, Henri E.; Wang, Ji-Guang; Westerink, Jan; White, James; Cloutier, Lyne; Taylor, Rod S.; Shore, Angela C.; McManus, Richard J.; Aboyans, V.; Campbell, John L. (American Heart Association, 2021-02-01)

  Systolic interarm differences in blood pressure have been associated with all-cause mortality and cardiovascular disease. We undertook individual participant data meta-analyses to (1) quantify independent associations of ...

• The patient, clinician and healthcare perspectives in evaluating care pathways for stable chest pain 

  Kwok, Chun Shing; Duckett, Simon; Satchithananda, Duwarakan; Potluri, Rahul; Morgan-Smith, Dot; Bellenger, Nick; Gunning, Mark; Mallen, Christian (Lippincott, Williams & Wilkins, 2021-05-12)

  Chest pain is one of the most common reasons for patients to present to healthcare professionals. One of the main challenges with the management of chest pain is the wide differential diagnosis, ranging from minor chest ...

• Outcomes of patients who undergo elective covered stent treatment for coronary artery aneurysms. 

  Will, Maximilian; Kwok, Chun Shing; Nagaraja, Vinayak; Potluri, Rahul; Weiss, Thomas W.; Mascherbauer, Julia; Schwarz, Konstantin (Elsevier, 2021-05-22)

  BACKGROUND: Coronary artery aneurysms (CAA) are reported in up to 5% of patients undergoing coronary angiography. Treatment of CAAs with covered stents has been reported in several case reports, however there is limited ...

• Massive pulmonary embolism in patients with extreme bleeding risk: a case series on the successful use of ultrasound-assisted, catheter directed thrombolysis in a district general hospital 

  He, Jingzhou; Clayton, B.; Gibbons, Michael; Watkinson, Anthony (Springer, 2020-09-04)

  Massive pulmonary embolism (PE), characterised by profound arterial hypotension, is a life-threatening emergency with a 90-day mortality of over 50%. Systemic thrombolysis can significantly reduce the risk of death or ...

• Physical activity assessment by accelerometry in people with heart failure 

  Gandhi, Manish; Taylor, R. S.; Dalal, H. M. (BioMed Central, 2020-08-12)

  Background: International guidelines for physical activity recommend at least 150 min per week of moderate-to-vigorous physical activity (MVPA) for adults, including those with cardiac disease. There is yet to be consensus ...

• The impact of an integrated heart failure service in a medium-sized district general hospital 

  Hawley, Alasdair; He, Jingzhou (BMJ, 2020-05)

  Objectives: Assessing the impact of a new integrated heart failure service (IHFS) in a medium-sized district general hospital (DGH) on heart failure (HF) mortality, readmission rates, and provision of HF care. Methods: ...

• Limit of detection of troponin discharge strategy versus usual care: randomised controlled trial 

  Reuben, Adam (BMJ, 2020-10)

  Introduction: The clinical effectiveness of a 'rule-out' acute coronary syndrome (ACS) strategy for emergency department patients with chest pain, incorporating a single undetectable high-sensitivity cardiac troponin ...

• Blood pressure in frail older adults: associations with cardiovascular outcomes and all-cause mortality 

  Masoli, Jane A.; Delgado, J.; Pilling, L. C.; Strain, David; Melzer, David (Oxford University Press, 2020-08-24)

  Background: Blood pressure (BP) management in frail older people is challenging. An randomised controlled trial of largely non-frail older people found cardiovascular and mortality benefit with systolic (S) BP target <120 ...

• Blinded physiological assessment of residual ischemia after successful angiographic percutaneous coronary intervention: the DEFINE PCI study 

  Sharp, Andrew S P (Elsevier, 2019-10)

  This study sought to evaluate the incidence and causes of an abnormal instantaneous wave-free ratio (iFR) after angiographically successful percutaneous coronary intervention (PCI).

• Sex differences in instantaneous wave-free ratio or fractional flow reserve-guided revascularization strategy 

  Sharp, Andrew S P (Elsevier, 2019-10)

  This study sought to evaluate sex differences in procedural characteristics and clinical outcomes of instantaneous wave-free ratio (iFR)- and fractional flow reserve (FFR)-guided revascularization strategies.

• Rapid treatment of moderate to severe hypertension using a novel protocol in a single-centre, before and after interventional study 

  Bellenger, Nicholas G; Shore, Angela C; Sharp, Andrew S P (Nature, 2019-10)

  Rapid treatment to target in hypertension may have beneficial effects on long-term outcomes. This has led to a new recommendation in the 2018 European hypertension guidelines for patients with grade II/III hypertension to ...

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