• Rapid, patient-led titration of basal insulin can be used to achieve tight glycaemic control in gestational diabetes mellitus with insulin resistance 

  Mayne, I.; Thomas, N.; McGovern, A. (BMJ, 2022-03-10)

  A woman with gestational diabetes mellitus (GDM) and significant insulin resistance in her third pregnancy was diagnosed with a fasting blood glucose reading of 5.7 mmol/L (103 mg/dL) at 28+1 weeks gestation and referred ...

• Postradioiodine Graves' management: The PRAGMA study 

  Perros, P.; Basu, A.; Boelaert, K.; Dayan, C.; Vaidya, B.; Williams, G. R.; Lazarus, J. H.; Hickey, J.; Drake, W. M.; Crown, A.; Orme, S. M.; Johnson, A.; Ray, D. W.; Leese, G. P.; Jones, T. H.; Abraham, P.; Grossman, A.; Rees, A.; Razvi, S.; Gibb, F. W.; Moran, C.; Madathil, A.; Žarković, M. P.; Plummer, Z.; Jarvis, S.; Falinska, A.; Velusamy, A.; Sanderson, V.; Pariani, N.; Atkin, S. L.; Syed, A. A.; Sathyapalan, T.; Nag, S.; Gilbert, J.; Gleeson, H.; Levy, M. J.; Johnston, C.; Sturrock, N.; Bennett, S.; Mishra, B.; Malik, I.; Karavitaki, N. (Wiley, 2022-03-11)

  OBJECTIVE: Thyroid status in the months following radioiodine (RI) treatment for Graves' disease can be unstable. Our objective was to quantify frequency of abnormal thyroid function post-RI and compare effectiveness of ...

• Evaluation of Evidence for Pathogenicity Demonstrates that BLK, KLF11 and PAX4 Should not be Included in Diagnostic Testing for MODY 

  Laver, T. W.; Wakeling, M. N.; Knox, O.; Colclough, K.; Wright, C. F.; Ellard, S.; Hattersley, A. T.; Weedon, M. N.; Patel, K. A. (American Diabetes Association, 2022-02-02)

  Maturity Onset Diabetes of the Young (MODY) is an autosomal dominant form of monogenic diabetes, reported to be caused by variants in 16 genes. Concern has been raised about whether variants in BLK (MODY11), KLF11 (MODY7) ...

• Type 1 Diabetes Patients With Different Residual Beta-Cell Function but Similar Age, HBA1c, and Cardiorespiratory Fitness Have Differing Exercise-Induced Angiogenic Cell Mobilisation 

  Taylor, G. S.; Shaw, A.; Scragg, J. H.; Smith, K.; Campbell, M. D.; McDonald, T. J.; Shaw, J. A.; Ross, M. D.; West, D. J. (Frontiers Media, 2022-02-11)

  BACKGROUND: Many individuals with type 1 diabetes retain residual beta-cell function. Sustained endogenous insulin and C-peptide secretion is associated with reduced diabetes related complications, but underlying mechanisms ...

• Clinical and genetic heterogeneity of HNF4A/HNF1A mutations in a multicentre paediatric cohort with hyperinsulinaemic hypoglycaemia 

  McGlacken-Byrne, S. M.; Mohammad, J. K.; Conlon, N.; Gubaeva, D.; Siersbæk, J.; Schou, A. J.; Demirbilek, H.; Dastamani, A.; Houghton, J. A. L.; Brusgaard, K.; Melikyan, M.; Christesen, H.; Flanagan, S. E.; Murphy, N. P.; Shah, P. (BioScientifica, 2022-02-22)

  OBJECTIVE: The phenotype mediated by HNF4A/HNF1A mutations is variable and includes diazoxide-responsive hyperinsulinaemic hypoglycaemia (HH) and maturity-onset diabetes of the young (MODY). DESIGN: We characterised an ...

• Understanding the pathogenesis of lean non-autoimmune diabetes in an African population with newly diagnosed diabetes 

  Kibirige, D.; Sekitoleko, I.; Lumu, W.; Jones, A. G.; Hattersley, A. T.; Smeeth, L.; Nyirenda, M. J. (Springer, 2022-04-01)

  AIMS/HYPOTHESIS: Apparent type 2 diabetes is increasingly reported in lean adult individuals in sub-Saharan Africa. However, studies undertaking robust clinical and metabolic characterisation of lean individuals with ...

• Capturing the real-world benefit of residual β-cell function during clinically important time-periods in established Type 1 diabetes 

  Taylor, G. S.; Shaw, A. C.; Smith, K.; Wason, J.; McDonald, T. J.; Oram, R. A.; Stevenson, E.; Shaw, J. A. M.; West, D. J. (Wiley, 2022-02-18)

  AIMS: Many individuals with type 1 diabetes retain residual β-cell function, with increased endogenous insulin secretion associated with reduced hyperglycaemia, hypoglycaemia and glycaemic variability. However, it is unknown ...

• A practical approach to continuous glucose monitoring (rtCGM) and FreeStyle Libre systems (isCGM) in children and young people with Type 1 diabetes 

  Soni, A.; Wright, N.; Agwu, J. C.; Timmis, A.; Drew, J.; Kershaw, M.; Moudiotis, C.; Regan, F.; Williams, E. C.; Wan, J.; Ng, S. M. (Elsevier, 2022-02-01)

  Real-time continuous glucose monitoring (rtCGM) and FreeStyle Libre glucose monitoring systems (isCGM) are new evolving technologies used in the management of Type 1 diabetes. They offer potential to improve diabetes control ...

• Utility of Diabetes Type-Specific Genetic Risk Scores for the Classification of Diabetes Type Among Multiethnic Youth 

  Oram, R. A.; Sharp, S. A.; Pihoker, C.; Ferrat, L.; Imperatore, G.; Williams, A.; Redondo, M. J.; Wagenknecht, L.; Dolan, L. M.; Lawrence, J. M.; Weedon, M. N.; D'Agostino, R.; Hagopian, W. A.; Divers, J.; Dabelea, D. (American Diabetes Association, 2022-03-21)

  OBJECTIVE: Genetic risk scores (GRSs) aid classification of diabetes type in White European adult populations. We aimed to assess the utility of GRS in the classification of diabetes type among racially/ethnically diverse ...

• Treatment of myocardial ischaemia-reperfusion injury in patients with ST-segment elevation myocardial infarction: promise, disappointment, and hope 

  He, J.; Bellenger, N. G.; Ludman, A. J.; Shore, A. C.; Strain, W. D. (IMR Press, 2022-01-17)

  Acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide. Timely reperfusion with primary percutaneous coronary intervention (PPCI) remains the gold standard in patients presenting with ...

• Increased referrals for congenital hyperinsulinism genetic testing in children with trisomy 21 reflects the high burden of non-genetic risk factors in this group 

  Hewat, T. I.; Laver, T. W.; Houghton, J. A. L.; Männistö, J. M. E.; Alvi, S.; Brearey, S. P.; Cody, D.; Dastamani, A.; De Los Santos La Torre, M.; Murphy, N.; Rami-Merhar, B.; Wefers, B.; Huopio, H.; Banerjee, I.; Johnson, M. B.; Flanagan, S. E. (Wiley, 2022-03-16)

  BACKGROUND: Hyperinsulinism results from inappropriate insulin secretion during hypoglycaemia. Down syndrome is causally linked to a number of endocrine disorders including Type 1 diabetes and neonatal diabetes. We noted ...

• Babies of South Asian and European Ancestry Show Similar Associations with Genetic Risk Score for Birth Weight Despite the Smaller Size of South Asian Newborns 

  Nongmaithem, S. S.; Beaumont, R. N.; Dedaniya, A.; Wood, A. R.; Ogunkolade, B. W.; Hassan, Z.; Krishnaveni, G. V.; Kumaran, K.; Potdar, R. D.; Sahariah, S. A.; Krishna, M.; Di Gravio, C.; Mali, I. D.; Sankareswaran, A.; Hussain, A.; Bhowmik, B. W.; Khan, A. K. A.; Knight, B. A.; Frayling, T. M.; Finer, S.; Fall, C. H.; Yajnik, C. S.; Freathy, R. M.; Hitman, G. A.; Chandak, G. R. (American Diabetes Association, 2022-01-21)

  Size at birth is known to be influenced by various fetal and maternal factors including genetic effects. South Asians have a high burden of low birthweight and cardiometabolic diseases, yet studies of common genetic ...

• Meeting the Challenge of Virtual Diabetes Care: A Consensus Viewpoint on the Positioning and Value of Oral Semaglutide in Routine Clinical Practice 

  Evans, M.; Morgan, A. R.; Bain, S. C.; Davies, S.; Hicks, D.; Brown, P.; Yousef, Z.; Dashora, U.; Viljoen, A.; Beba, H.; Strain, W. D. (Springer, 2022-01-19)

  While glucagon-like peptide-1 receptor agonists (GLP-1 RAs), such as semaglutide, are among the most effective drugs for treating people with type 2 diabetes (T2D), they are clinically under-utilised. Until recently, the ...

• Improvements in Awareness and Testing Have Led to a Threefold Increase Over 10 Years in the Identification of Monogenic Diabetes in the U.K 

  Pang, L.; Colclough, K. C.; Shepherd, M. H.; McLean, J.; Pearson, E. R.; Ellard, S.; Hattersley, A. T.; Shields, B. M. (American Diabetes Association, 2022-01-21)

  OBJECTIVE: Maturity-onset diabetes of the young (MODY) is a rare monogenic form of diabetes. In 2009, >80% of U.K. cases were estimated to be misdiagnosed. Since then, there have been a number of initiatives to improve the ...

• Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study 

  Martin, S.; Sorokin, E. P.; Thomas, E. L.; Sattar, N.; Cule, M.; Bell, J. D.; Yaghootkar, H. (American Diabetes Association, 2022-02-01)

  OBJECTIVE: Fat content and volume of liver and pancreas are associated with risk of diabetes in observational studies; whether these associations are causal is unknown. We conducted a Mendelian randomization (MR) study to ...

• Response to Comment on Meek et al. Reappearance of C-Peptide During the Third Trimester in Type 1 Diabetes Pregnancy: Pancreatic Regeneration or Fetal Hyperinsulinism? Diabetes Care 2021;44:1826-1834 

  Meek, C. L.; Oram, R. A.; McDonald, T. J.; Feig, D. S.; Hattersley, A. T.; Murphy, H. R. (American Diabetes Association, 2022-02-01)

• Lissencephaly-pachygyria spectrum in a North Indian boy with Wolcott-Rallison syndrome due to homozygous deletion of exon 1 in the EIF2AK3 gene 

  Gupta, A.; Reddy, C.; Saini, L.; Yadav, J.; Kumar, R.; Houghton, J.; Ellard, S.; Dayal, D. (Termedia, 2021-12-20)

  BACKGROUND: Wolcott-Rallison syndrome (WRS) is a rare autosomal recessive disorder characterized by neonatal diabetes mellitus (NDM), epiphyseal dysplasia, and hepatic and renal dysfunction. Although neuro-psychological ...

• Use of Social Media as a Platform for Education and Support for People With Diabetes During a Global Pandemic 

  Thomas, R. L.; Alabraba, V.; Barnard, S.; Beba, H.; Brake, J.; Cox, A.; Bowker, R.; Edwards, D.; Epps, A.; Fletcher-Salt, T.; Holmes, P.; Kar, P. S.; Kausar, N.; Kelly, B.; Leveridge, M.; Newland-Jones, P.; Ng, S. M.; Puttana, A.; Stewart, R. (Sage, 2021-10-31)

  BACKGROUND: Patient education is a fundamental aspect of self-management of diabetes. The aim of this study was to understand whether a social media platform is a viable method to deliver education to people with diabetes ...

• Systematic genetic testing for recessively inherited monogenic diabetes: a cross-sectional study in paediatric diabetes clinics 

  Patel, K. A.; Ozbek, M. N.; Yildiz, M.; Guran, T.; Kocyigit, C.; Acar, S.; Siklar, Z.; Atar, M.; Colclough, K.; Houghton, J.; Johnson, M. B.; Ellard, S.; Flanagan, S. E.; Cizmecioglu, F.; Berberoglu, M.; Demir, K.; Catli, G.; Bas, S.; Akcay, T.; Demirbilek, H.; Weedon, M. N.; Hattersley, A. T. (Springer, 2021-10-23)

  AIMS/HYPOTHESIS: Current clinical guidelines for childhood-onset monogenic diabetes outside infancy are mainly focused on identifying and testing for dominantly inherited, predominantly MODY genes. There are no systematic ...

• Syndromic Monogenic Diabetes Genes Should be Tested in Patients With a Clinical Suspicion of MODY 

  Colclough, K.; Ellard, S.; Hattersley, A.; Patel, K. (American Diabetes Association, 2021-11-17)

  At present, outside of infancy, genetic testing for monogenic diabetes is typically for mutations in MODY genes that predominantly result in isolated diabetes. Monogenic diabetes syndromes are usually only tested when this ...

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