Browsing pre-2014 RD&E publications by Issue Date
Now showing items 21-40 of 295
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A cost consequence study of the impact of a dermatology-trained practice nurse on the quality of life of primary care patients with eczema and psoriasis
(Royal College of General Practitioners, 2000-08-24)BACKGROUND: The practice nurse is central to the development of a primary care-led National Health Service. Skin diseases can have a major impact on patients' lives but general practitioners (GPs) lack many of the skills ... -
Healing at skin graft donor sites dressed with chitosan
(Elsevier, 2000-09-23)Chitosan is a derivative of chitin, extracted from the exoskeleton of lobsters, crabs and shrimps. As a semi-permeable biological dressing, it maintains a sterile wound exudate beneath a dry scab, preventing dehydration ... -
beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.
(Highwire, 2001-02)beta-Cell transcription factor genes are important in the pathophysiology of the beta-cell, with mutations in hepatocyte nuclear factor (HNF)-1alpha, HNF-4alpha, insulin promoter factor (IPF)-1, HNF-1beta, and NeuroD1/BETA2, ... -
Home or surgery based screening for chronic obstructive pulmonary disease (COPD)?
(Nature Research, 2001-06-01)AIMS: To compare the effectiveness of opportunistic spirometric screening of patients attending a general practice surgery with screening on randomly selected home visits. METHOD: 100 patients aged 45+ attending the Honiton ... -
Treatment demands and differential treatment of patients with cystic fibrosis and their siblings: patient, parent and sibling accounts.
(Wiley, 2001-07)Cystic fibrosis (CF) is a progressive disease with no known cure. Advances in diagnosis and treatment have resulted in patients living longer and thus families live with the illness for longer. Treatments are becoming ... -
Managing Spasticity in People With Multiple Sclerosis: A Goal-Oriented Approach to Intrathecal Baclofen Therapy
(Consortium of Multiple Sclerosis Centers, 2001-12) -
Improving foot care for people with diabetes mellitus--a randomized controlled trial of an integrated care approach
(Wiley, 2001-12-24)AIMS: To evaluate a model of integrated diabetic footcare, for identification and clinical management of the high risk diabetic foot, centred on the primary care-based diabetic annual review. METHODS: A pragmatic randomized ... -
The role of the nurse in the management of spasticity: care pathway
(Multiple Sclerosis Trust, 2002) -
Head lice infestation: bug busting vs. traditional treatment
(Wiley, 2002-02-02)The two main methods of managing head lice infestation in the UK are head lice lotions and bug busting; there is no conclusive evidence as to which of these methods is most effective. The aim of this study was to compare ... -
A pragmatic randomised controlled trial of an asthma nurse in general practice
(Nature Research, 2002-03-01)AIM: To measure the impact of a nurse led asthma clinic on the quality of life of patients with asthma. DESIGN: A randomised controlled trial with delayed intervention in the control group. OUTCOMES: Primary outcome measure: ... -
Assessing communication skills of GP registrars: a comparison of patient and GP examiner ratings
(Wiley, 2002-04-10)CONTEXT: General practice. OBJECTIVES: To compare ratings of GP registrars' communication skills by patients and GP examiners. DESIGN: A comparative study where the communication skills of GP registrars were assessed both ... -
Maturity-onset diabetes of the young caused by a balanced translocation where the 20q12 break point results in disruption upstream of the coding region of hepatocyte nuclear factor-4alpha (HNF4A) gene.
(Highwire, 2002-07)Monogenic human disorders have been used as paradigms for complex genetic disease and as tools for establishing important insights into mechanisms of gene regulation and transcriptional control. Maturity-onset diabetes of ... -
Heterogeneity in young adult onset diabetes: aetiology alters clinical characteristics.
(Wiley, 2002-09)To describe the characteristics of hepatocyte nuclear factor (HNF) 1 alpha mutation carriers diagnosed with diabetes after 25 years and compare them with young-onset Type 2 diabetic patients (YT2D) diagnosed at the same age. -
Abnormal splicing of hepatocyte nuclear factor 1 alpha in maturity-onset diabetes of the young.
(Springer, 2002-10)Mutations in the HNF-1 alpha gene result in maturity-onset diabetes of the young (MODY); an early-onset, dominantly inherited form of diabetes caused by pancreatic beta-cell dysfunction. Splice site mutations represent ... -
The differential blood pressure sign in general practice: prevalence and prognostic value
(Oxford University Press, 2002-10-03)BACKGROUND: Patients sometimes have differences of > or =20/10 mmHg in their blood pressure depending on which arm is measured. The prevalence and prognostic value of this finding in general practice are unknown. If these ... -
Managing severe lower limb spasticity in multiple sclerosis: does intrathecal phenol have a role?
(BMJ, 2002-12)Established treatment options for managing severe lower limb spasticity and associated pain are of limited value in people with advanced multiple sclerosis (MS). This has resulted in a resurgence of the use of lumbar ... -
Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1alpha gene mutation carriers.
(Highwire, 2002-12)In animals, experimentally induced maternal hyperglycemia during pregnancy results in hyperglycemic offspring. Similarly, Pima Indian offspring with mothers who are diabetic at the time of pregnancy have increased risk of ... -
Illustrating the ethical dimensions of action research.
(RCN, 2002-12-01)Graham Williamson and Sue Prosser discuss the ethical dimensions of action research, informed by their experiences of participation in an action research project in the workplace. -
A patient feedback tool
(RCN Publishing, 2002-12-01)