Browsing pre-2014 RD&E publications by Title
Now showing items 60-79 of 295
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Defining the genetic aetiology of monogenic diabetes can improve treatment.
(Taylor & Francis, 2006-09)A molecular genetic diagnosis is now possible for > 80% of patients with monogenic diabetes. This not only provides accurate information regarding inheritance and prognosis, but can inform treatment decisions and improve ... -
Dental amalgam tattoo consequent to a human bite injury
(Elsevier, 2005-12) -
Determinants of insulin concentrations in healthy 1-week-old babies in the community: applications of a bloodspot assay
(Elsevier, 2005-10-13)BACKGROUND: Epidemiological research into insulin secretion and insulin action would be helped by improved ability to measure insulin concentrations in large groups of healthy babies in the neonatal period. Such research ... -
The development and validation of a clinical prediction model to determine the probability of MODY in patients with young-onset diabetes.
(Springer, 2012-05)Diagnosing MODY is difficult. To date, selection for molecular genetic testing for MODY has used discrete cut-offs of limited clinical characteristics with varying sensitivity and specificity. We aimed to use multiple, ... -
Developmental facial paralysis: A review
(Elsevier, 2011-10) -
Diagnosis of type 2 diabetes in primary care
(SAGE Publications, 2003-09-01)Little is known about the impact of case-finding and protocol-driven screening at a practice level on the increasing prevalence of type 2 diabetes. This cross-sectional study investigated the diagnostic process in 154 ... -
Did the 'Be Clear on Bowel Cancer' public awareness campaign pilot result in a higher rate of cancer detection?
(BMJ, 2013-07)To assess the impact of a 7-week public bowel cancer awareness campaign pilot by reviewing the number of 2-week referrals from general practitioners (GPs) to hospital, endoscopic procedures and new cancers diagnosed ... -
Directed evolution of aldolases for exploitation in synthetic organic chemistry.
(Elsevier, 2008-06-15)This review focuses on the directed evolution of aldolases with synthetically useful properties. Directed evolution has been used to address a number of limitations associated with the use of wild-type aldolases as catalysts ... -
Do metronomes improve the quality of life in people with Parkinson's disease? A pragmatic, single-blind, randomized cross-over trial
(Sage, 2010-05-18)OBJECTIVE: To evaluate the effect of acoustic cueing using metronomes on the quality of life of people with moderate to severe Parkinson's disease. STUDY DESIGN: Pragmatic, single-blind, randomized cross-over trial. ... -
Do patients want copies of their GP letters? - our experience with 7250 patients
(Wiley, 2007-07-10)A prospective study was performed to investigate whether patients would actively request a copy of their GP letters following an outpatient consultation. The study was performed at two sites and involved 7250 Trauma & ... -
Does a patient survey make a difference?
(Ingenta, 2004-02-01)There is little known about whether feedback from patient surveys can make a real difference to future patient experience of general practice care. In this study, a sample of 12 general practices in the southwest of England ... -
Does concentration of surgical expertise improve outcomes for laparoscopic cholecystectomy? 9 year audit cycle
(Elsevier, 2013-12)Evidence from surgery shows that high volume is often associated with better outcomes. The aim of this study was to investigate this principle related to elective laparoscopic cholecystectomy practice. A retrospective ... -
Early oxygen uptake recovery following exercise testing in children with chronic chest diseases.
(Wiley, 2009-05)The value of exercise testing as an objective measure of disease severity in patients with chronic chest diseases (CCD) is becoming increasingly recognized. The aim of this study was to investigate changes in oxygen uptake ... -
Easier bone graft harvesting when performing a tibiotalocalcaneal fusion
(Royal College of Surgeons, 2013-10-01) -
ED, email, emess!
(BMJ, 2013-01)Email has transformed communication in the National Health Service. Handling a torrent of unfocused communication is a potential burden on the clinician's time and a source of stress at work. A prospective study of the ... -
EDTA improves stability of whole blood C-peptide and insulin to over 24 hours at room temperature.
(PLoS One, 2012)C-peptide and insulin measurements in blood provide useful information regarding endogenous insulin secretion. Conflicting evidence on sample stability and handling procedures continue to limit the widespread clinical use ... -
Effects of training and supervision on recurrence rate after inguinal hernia repair
(Wiley, 2004-06)There is little information about the effects of operative experience and supervision of trainees on outcome in inguinal hernia surgery, one of the cornerstone operations of basic surgical training. -
Elbow extension test to rule out elbow fracture: multicentre, prospective validation and observational study of diagnostic accuracy in adults and children
(BMJ, 2008-12-09)OBJECTIVE: To determine whether full elbow extension as assessed by the elbow extension test can be used in routine clinical practice to rule out bony injury in patients presenting with elbow injury. DESIGN: Adults: ... -
Epithelial ovarian cancer-induced angiogenic phenotype of human omental microvascular endothelial cells may occur independently of VEGF signaling.
(Elsevier, 2013-12-01)Epithelial ovarian cancer (EOC) metastasizes transcoelomically to the peritoneum and omentum, and despite surgery and chemotherapy, recurrent disease is likely. Metastasis requires the induction of proangiogenic changes ...