Browsing 2014 RD&E publications by Title
Now showing items 1-20 of 189
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The 0.1% of the population with glucokinase monogenic diabetes can be recognized by clinical characteristics in pregnancy: the Atlantic Diabetes in Pregnancy cohort.
(American Diabetes Association, 2014-02)Identifying glucokinase monogenic diabetes (GCK-MODY) in pregnancy is important, as management is different from management for other forms of gestational diabetes mellitus (GDM) and there is no increased maternal risk of ... -
2014 European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children
(Karger, 2014-06-01)This guideline has been produced as the official statement of the European Thyroid Association guideline committee. Subclinical hypothyroidism (SCH) in pregnancy is defined as a thyroid-stimulating hormone (TSH) level above ... -
Accurate femoral stem depth insertion in total hip replacement
(Royal College of Surgeons, 2014-07-01) -
Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease.
(Nature, 2014-08)Monogenic causes of autoimmunity provide key insights into the complex regulation of the immune system. We report a new monogenic cause of autoimmunity resulting from de novo germline activating STAT3 mutations in five ... -
Acute bronchodilator responses decline progressively over 4 years in patients with moderate to very severe COPD.
(BioMed Central, 2014-08-31)We previously reported a progressive decline in absolute responses of FEV1 and FVC to a near-maximal dose of 2 different short-acting bronchodilators over 4 years. Since varying host factors and the method of expressing ... -
Acute double flexor tendon ruptures following injection of collagenase clostridium histolyticum (Xiapex) for Dupuytren's contracture.
(BMJ, 2014)We report a case of acute (24 h) double flexor tendon rupture of the little finger after a single injection of collagenase clostridium histolyticum into a palmar Dupuytren's contracture cord which caused metacarpophalangeal ... -
Additional benefit of combined therapy with melatonin and apoptotic adipose-derived mesenchymal stem cell against sepsis-induced kidney injury.
(Wiley, 2014-08)This study tested whether combined therapy with melatonin and apoptotic adipose-derived mesenchymal stem cells (A-ADMSCs) offered additional benefit in ameliorating sepsis-induced acute kidney injury. Adult male Sprague-Dawley ... -
Afatinib use in non-small cell lung cancer previously sensitive to epidermal growth factor receptor inhibitors: the United Kingdom Named Patient Programme
(Elsevier, 2014-07-01)INTRODUCTION: Afatinib prolongs progression-free survival (PFS) in patients with non-small cell lung cancer (NSCLC) who were previously sensitive to erlotinib or gefitinib. This study investigated experience of afatinib ... -
Air travellers' awareness of the preventability of otic barotrauma
(Cambridge Journals, 2014-06-01)OBJECTIVE: Otic barotrauma is common among air travellers and can cause severe otalgia, perforation of the tympanic membrane and hearing loss. Many prevention measures exist, with varying evidence to support their use. ... -
All patients with a postdural puncture headache should receive an epidural blood patch
(Elsevier, 2014-05-01)Postdural puncture headache (PDPH) is an important complication of obstetric epidural anaesthesia and analgesia. Though often self-limiting, PDPH is unpleasant, at times incapacitating, and associated with complications, ... -
Anaemia; a contraindication to elective surgery for colorectal cancer?
(Wiley, 2014-10-01) -
Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man.
(Cell Press, 2014-01-07)Understanding transcriptional regulation of pancreatic development is required to advance current efforts in developing beta cell replacement therapies for patients with diabetes. Current knowledge of key transcriptional ... -
Angle-closure glaucoma on long-haul flights
(JAMA, 2014-12-01)IMPORTANCE: Unlike other modes of long-distance travel, long-haul flights delay urgent, specialist medical treatment until the destination is reached or the plane is diverted. Angle-closure glaucoma (ACG) occurring during ... -
An apology for beta blockers
(Elsevier, 2014-08-01) -
Are we seeing the effects of public awareness campaigns? A 10-year analysis of Breslow thickness at presentation of malignant melanoma in the South West of England
(Elsevier, 2014-03-01)INTRODUCTION: The last 20 years has seen a marked improvement in skin cancer awareness campaigns. We sought to establish whether this has affected the presenting Breslow thickness of malignant melanoma in the South West. ... -
Arthroscopic capsular release for idiopathic frozen shoulder with intra-articular injection and a controlled manipulation
(Royal College of Surgeons, 2014-01-01)INTRODUCTION: The aim of this prospective study was to assess the immediate and long-term effectiveness of arthroscopic capsular release in a large cohort of patients with a precise and isolated diagnosis of stage II ... -
Assessing visual control during simulated and live operations: gathering evidence for the content validity of simulation using eye movement metrics.
(Springer, 2014-06)Although virtual reality (VR) simulators serve an important role in the training and assessment of surgeons, they need to be evaluated for evidence of validity. Eye-tracking technology and measures of visual control have ... -
The association between postprandial urinary C-peptide creatinine ratio and the treatment response to liraglutide: a multi-centre observational study.
(Wiley, 2014-04)The response to glucagon-like peptide 1 receptor agonist treatment may be influenced by endogenous β-cell function. We investigated whether urinary C-peptide creatinine ratio assessed before or during liraglutide treatment ... -
Associations between stroke mortality and weekend working by stroke specialist physicians and registered nurses: prospective multicentre cohort study
(PLoS, 2014-08-01)BACKGROUND: Observational studies have reported higher mortality for patients admitted on weekends. It is not known whether this "weekend effect" is modified by clinical staffing levels on weekends. We aimed to test the ... -
Authors' reply to Dalzell and Cannon and Satchithananda and colleagues
(BMJ, 2014-11-01)