Browsing 2014 RD&E publications by Issue Date
Now showing items 1-20 of 186
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Identifying good responders to glucose lowering therapy in type 2 diabetes: implications for stratified medicine.
(PLoS, 2014)Defining responders to glucose lowering therapy can be important for both clinical care and for the development of a stratified approach to diabetes management. Response is commonly defined by either HbA1c change after ... -
Acute double flexor tendon ruptures following injection of collagenase clostridium histolyticum (Xiapex) for Dupuytren's contracture.
(BMJ, 2014)We report a case of acute (24 h) double flexor tendon rupture of the little finger after a single injection of collagenase clostridium histolyticum into a palmar Dupuytren's contracture cord which caused metacarpophalangeal ... -
Plastic and reconstructive surgery
(McGraw Hill, 2014) -
Effect of the holiday season in patients with diabetes: glycemia and lipids increase postholiday, but the effect is small and transient.
(American Diabetes Association, 2014) -
The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells.
(Springer, 2014-01)Classically, type 1 diabetes is thought to proceed to absolute insulin deficiency. Recently developed ultrasensitive assays capable of detecting C-peptide under 5 pmol/l now allow very low levels of C-peptide to be detected ... -
Cross-sectional and longitudinal studies suggest pharmacological treatment used in patients with glucokinase mutations does not alter glycaemia
(Springer, 2014-01-01)AIMS/HYPOTHESIS: Heterozygous glucokinase (GCK) mutations cause mild, fasting hyperglycaemia from birth. Although patients are usually asymptomatic and have glycaemia within target ranges, some are put on pharmacological ... -
Postconcussion syndrome (PCS) in the emergency department: predicting and pre-empting persistent symptoms following a mild traumatic brain injury
(BMJ, 2014-01-01)Head injuries across all age groups represent an extremely common emergency department (ED) presentation. The main focus of initial assessment and management rightly concentrates on the need to exclude significant pathology, ... -
Mucinous adenocarcinoma of the umbilicus 8 years following anterior resection for villous adenoma of the rectum
(Oxford Journals, 2014-01-01)We present the case of an 80-year-old retired consultant histopathologist who presented to us with a malignant umbilical mass 8years following resection of a sigmoid adenoma. The report details initial investigation and ... -
The use of the 70 degrees arthroscope for anatomic femoral and tibial tunnel placement and tunnel viewing in anterior cruciate ligament reconstruction
(Elsevier, 2014-01-01)The use of the 70 degrees arthroscope in knee surgery is not a new concept, and it is frequently used in posterior cruciate ligament reconstruction. There are previous reports of its use in anterior cruciate ligament ... -
Beta-blockers in liver cirrhosis
(Hellenic Society of Gastroenterology, 2014-01-01)Since the original description of the effectiveness of beta-blockers in lowering the portal pressure and therefore the risk of variceal bleeding, more than 500 articles in the English literature on the use of non selective ... -
Arthroscopic capsular release for idiopathic frozen shoulder with intra-articular injection and a controlled manipulation
(Royal College of Surgeons, 2014-01-01)INTRODUCTION: The aim of this prospective study was to assess the immediate and long-term effectiveness of arthroscopic capsular release in a large cohort of patients with a precise and isolated diagnosis of stage II ... -
Screw and cement augmentation of patella defects in knee arthroplasty
(Royal College of Surgeons, 2014-01-01) -
A novel way to secure a chest drain
(Royal College of Surgeons, 2014-01-01) -
Improving weekend handover between junior doctors on medical and surgical wards.
(BMJ, 2014-01-03)Poor weekend handover has been implicated as one of the causes of observed higher mortality rates at weekends in UK hospitals. In a large teaching hospital we, a group of junior doctors, set about improving the quality and ... -
Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man.
(Cell Press, 2014-01-07)Understanding transcriptional regulation of pancreatic development is required to advance current efforts in developing beta cell replacement therapies for patients with diabetes. Current knowledge of key transcriptional ... -
Prevalence of vascular complications among patients with glucokinase mutations and prolonged, mild hyperglycemia
(JAMA, 2014-01-15)IMPORTANCE: Glycemic targets in diabetes have been developed to minimize complication risk. Patients with heterozygous, inactivating glucokinase (GCK) mutations have mild fasting hyperglycemia from birth, resulting in an ... -
Can I treat this pregnant patient with botulinum toxin?
(BMJ, 2014-02)Botulinum toxin type A (BoNT-A) is used extensively in the neurological setting, most commonly for the management of dystonia and spasticity. It is inevitable that female patients who derive a significant benefit from ... -
The 0.1% of the population with glucokinase monogenic diabetes can be recognized by clinical characteristics in pregnancy: the Atlantic Diabetes in Pregnancy cohort.
(American Diabetes Association, 2014-02)Identifying glucokinase monogenic diabetes (GCK-MODY) in pregnancy is important, as management is different from management for other forms of gestational diabetes mellitus (GDM) and there is no increased maternal risk of ... -
Parents' attitudes toward the use of complementary therapy by their children with moderate or severe cerebral palsy.
(Mary Ann Liebert, 2014-02)To describe the use of, and attitudes toward, complementary therapy (CT) by parents of children with moderate to severe cerebral palsy. -
Use of rectus sheath catheters for pain relief in patients undergoing major pelvic urological surgery
(Wiley, 2014-02-01)OBJECTIVE: To report on the safety and efficacy of rectus sheath blocks, 'topped-up' using bilateral rectus sheath catheters (RSCs), in patients undergoing major open urological surgery. METHODS: The RSCs were inserted ...