Research outputs from the Healthcare for Older People department at the RD&E.

Recent Submissions

  • Hospital at Home admission avoidance with comprehensive geriatric assessment to maintain living at home for people aged 65 years and over: a RCT 

    Shepperd, S.; Cradduck-Bamford, A.; Butler, C.; Ellis, G.; Godfrey, M.; Gray, A.; Hemsley, A.; Khanna, P.; Langhorne, P.; Mäkelä, P.; Mort, S.; Ramsay, S.; Schiff, R.; Singh, S.; Smith, S.; Stott, D. J.; Tsiachristas, A.; Wilkinson, A.; Yu, L. M.; Young, J. (NIHR Journals Library, 2022-01-01)
    BACKGROUND: Evidence is required to guide the redesign of health care for older people who require hospital admission. OBJECTIVES: We assessed the clinical effectiveness and cost-effectiveness of geriatrician-led admission ...
  • The Population-Wide Risk-Benefit Profile of Extending the Primary COVID-19 Vaccine Course Compared with an mRNA Booster Dose Program 

    Shiri, T.; Evans, M.; Talarico, C. A.; Morgan, A. R.; Mussad, M.; Buck, P. O.; McEwan, P.; Strain, W. D. (MDPI, 2022-01-18)
    The vaccination program is reducing the burden of COVID-19. However, recently, COVID-19 infections have been increasing across Europe, providing evidence that vaccine efficacy is waning. Consequently, booster doses are ...
  • Is comprehensive geriatric assessment hospital at home a cost-effective alternative to hospital admission for older people? 

    Singh, S.; Gray, A.; Shepperd, S.; Stott, D. J.; Ellis, G.; Hemsley, A.; Khanna, P.; Ramsay, S.; Schiff, R.; Tsiachristas, A.; Wilkinson, A.; Young, J. (Oxford University Press, 2022-01-06)
    BACKGROUND: hospital level healthcare in the home guided by comprehensive geriatric assessment (CGA) might provide a less costly alternative to hospitalisation for older people. OBJECTIVE: to determine the cost-effectiveness ...
  • Hypertension management in older patients-Are the guideline blood pressure targets appropriate? 

    Masoli, J. A. H.; Sheppard, J. P.; Rajkumar, C. (Oxford University Press, 2022-01-06)
  • Telephone Interview for Cognitive Status Scores Associate with Cognitive Impairment and Alzheimer's Disease Pathology at Death 

    Robinson, A. C.; Davidson, Y. S.; Roncaroli, F.; Minshull, J.; Tinkler, P.; Cairns, M.; Horan, M. A.; Payton, A.; Mann, D. M. A. (IOS Press, 2021-11-09)
    BACKGROUND: Early diagnosis of Alzheimer's disease (AD) provides an opportunity for early intervention. Cognitive testing has proven to be a reliable way to identify individuals who may be at risk of AD. The Telephone ...
  • The Value of Insulin Degludec in Frail Older Adults with Type 2 Diabetes 

    Strain, W. D.; Morgan, A. R.; Evans, M. (Springer, 2021-11-01)
    Insulin represents a mainstay of glucose-lowering therapy for many adults with type 2 diabetes mellitus (T2DM). Insulin treatments prescribed as standard care for the majority of people with T2DM, such as basal human ...
  • Management and outcomes in critically ill nonagenarian versus octogenarian patients 

    Bruno, R. R.; Wernly, B.; Kelm, M.; Boumendil, A.; Morandi, A.; Andersen, F. H.; Artigas, A.; Finazzi, S.; Cecconi, M.; Christensen, S.; Faraldi, L.; Lichtenauer, M.; Muessig, J. M.; Marsh, B.; Moreno, R.; Oeyen, S.; Öhman, C. A.; Pinto, B. B.; Soliman, I. W.; Szczeklik, W.; Valentin, A.; Watson, X.; Leaver, S.; Boulanger, C.; Walther, S.; Schefold, J. C.; Joannidis, M.; Nalapko, Y.; Elhadi, M.; Fjølner, J.; Zafeiridis, T.; De Lange, D. W.; Guidet, B.; Flaatten, H.; Jung, C. (BioMed Central, 2021-10-19)
    BACKGROUND: Intensive care unit (ICU) patients age 90 years or older represent a growing subgroup and place a huge financial burden on health care resources despite the benefit being unclear. This leads to ethical problems. ...
  • Blood pressure, frailty and dementia 

    Masoli, J. A. H.; Delgado, J. (Elsevier, 2021-09-16)
    High blood pressure (BP) affects 75% of people aged over 70. Ageing alters BP homeostasis, resulting in postural hypotension and increased BP variability. Co-morbidity and frailty add complexity to understanding BP changes ...
  • Acute sarcopenia changes following hospitalization: influence of pre-admission care dependency level 

    De Spiegeleer, A.; Kahya, H.; Sanchez-Rodriguez, D.; Piotrowicz, K.; Surquin, M.; Marco, E.; Detremerie, C.; Hussein, D.; Hope, S.; Dallmeier, D.; Decker, G.; Hrnciarikova, D.; Czesak, J.; Toscano-Rico, M.; Meza-Valderrama, D.; Bahat, G.; Descamps, A.; Wynendaele, E.; Elewaut, D.; Vankova, H.; Landi, F.; Benoit, F.; Gasowski, J.; Van Den Noortgate, N. (Oxford University Press, 2021-08-09)
    INTRODUCTION: Hospitalization is associated with acute changes in sarcopenia status in older people, but the influencing factors are not fully understood. Pre-admission care dependency level as a risk factor has not yet ...
  • Cerebral small vessel disease, systemic vascular characteristics and potential therapeutic targets 

    Elyas, S.; Adingupu, D. D.; Aizawa, K.; Casanova, F.; Gooding, K.; Fulford, J.; Mawson, D.; Gates, P. E.; Shore, A. C.; Strain, D. (Impact Journals, 2021-09-21)
    INTRODUCTION: Cerebral small vessel disease (SVD) is prevalent in the elderly population and is associated with increased risk of dementia, stroke and disability. Currently there are no clear targets or strategies for the ...
  • Diffuse encephalitic toxoplasmosis in HIV. 

    Pearce, Jasmine; Sheridan, Ray; Shaw, Johnathan; Senior, Thomas (BMJ, 2021-03-18)
    This case demonstrates an atypical radiological presentation of cerebral toxoplasmosis in a 62-year-old HIV-positive patient. The diagnosis is discussed alongside MRI imaging, laboratory results and treatment. Central ...
  • EAES rapid guideline: appendicitis in the elderly 

    Antoniou, Stavros A.; Mavridis, Dimitris; Kontouli, Katerina Maria; Drakopoulos, Vasileios; Gorter-Stam, Marguerite; Eriksson, Sture; Leone, Marc; Pérez-Bocanegra, Maria Carmen; Smart, Neil J.; Milone, Marco; Carrano, Francesco Maria; Antoniou, George A.; Vandvik, Per Olav (Springer, 2021-07-01)
    BACKGROUND: There is a lack of trustworthy evidence-informed guidelines on the diagnosis and management of acute appendicitis in elderly patients. METHODS: We developed a rapid guideline in accordance with GRADE and AGREE ...
  • Developing a UK sarcopenia registry: recruitment and baseline characteristics of the SarcNet pilot 

    Witham, Miles D.; Heslop, Philip; Dodds, Richard M.; Clegg, Andrew P.; Hope, Suzy V.; McDonald, Claire; Smithard, David; Storey, Bryony; Tan, Ai Lyn; Thornhill, Anna; Sayer, Avan A. (Oxford University Press, 2021-05-26)
    BACKGROUND: sarcopenia registries are a potential method to meet the challenge of recruitment to sarcopenia trials. We tested the feasibility of setting up a UK sarcopenia registry, the feasibility of recruitment methods ...
  • Diabetes and Frailty: An Expert Consensus Statement on the Management of Older Adults with Type 2 Diabetes 

    Strain, W. David; Down, Su; Brown, Pam; Puttanna, Amar; Sinclair, Alan (Springer, 2021-05-01)
    Prognosis and appropriate treatment goals for older adults with diabetes vary greatly according to frailty. It is now recognised that changes may be needed to diabetes management in some older people. Whilst there is clear ...
  • Characterising Alzheimer's Disease with EEG-based Energy Landscape Analysis 

    Klepl, Dominik; He, Fei; Wu, Min; Blackburn, Daniel J.; De Marco, Matteo; Sarrigiannis, Ptolemaios (0, 2021-02-01)
    Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, with around 50 million patients worldwide. Accessible and non-invasive methods of diagnosing and characterising AD are therefore urgently ...
  • 52 I’m on the Floor and Can’t Get up and it’s Really Annoying: A Qualitative Investigation of Patient and Staff Perceptions of Options for Getting up From the Floor Following A Fall 

    Swancutt, D; Hope, S V; Kent, B; Robinson, M; Goodwin, V (Oxford University Press, 2021-03-01)
    Falls are the most common reason for ambulance call-outs resulting in non-conveyance. Even in the absence of injury, only half of those who have fallen can get themselves up off the floor. Many remain there for over an ...
  • 12 Being Non-Frail and Free From Cardiovascular Disease Reduces COVID-19 Risk in 269,164 Older UK Biobank Participants 

    Masoli, J; Atkins, J; Delgado, J; Pilling, L; Melzer, D (Oxford University Press, 2021-03-01)
    Older adults are at increased risk of COVID-19, resulting in public health shielding measures for all adults over 70 in the UK. Frailty has been proposed for risk stratification in COVID-19 with limited evidence. Cardiovascular ...
  • Clinical judgement of GPs for the diagnosis of dementia: a diagnostic test accuracy study 

    Creavin, S. T.; Haworth, J.; Fish, M.; Cullum, S.; Bayer, A.; Purdy, S.; Ben-Shlomo, Y. (Royal College of General Practitioners, 2021-07-27)
    BACKGROUND: GPs often report using clinical judgement to diagnose dementia. AIM: Investigate the accuracy of GPs' clinical judgement for the diagnosis of dementia. DESIGN & SETTING: Diagnostic test accuracy study, recruiting ...
  • A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex 

    Smith, R. G.; Pishva, E.; Shireby, G.; Smith, A. R.; Roubroeks, J. A. Y.; Hannon, E.; Wheildon, G.; Mastroeni, D.; Gasparoni, G.; Riemenschneider, M.; Giese, A.; Sharp, A. J.; Schalkwyk, L.; Haroutunian, V.; Viechtbauer, W.; van den Hove, D. L. A.; Weedon, M.; Brokaw, D.; Francis, P. T.; Thomas, A. J.; Love, S.; Morgan, K.; Walter, J.; Coleman, P. D.; Bennett, D. A.; De Jager, P. L.; Mill, J.; Lunnon, K. (Nature, 2021-06-10)
    Epigenome-wide association studies of Alzheimer's disease have highlighted neuropathology-associated DNA methylation differences, although existing studies have been limited in sample size and utilized different brain ...
  • Publisher Correction: Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis 

    Wernly, B.; Bruno, R. R.; Kelm, M.; Boumendil, A.; Morandi, A.; Andersen, F. H.; Artigas, A.; Finazzi, S.; Cecconi, M.; Christensen, S.; Faraldi, L.; Lichtenauer, M.; Muessig, J. M.; Marsh, B.; Moreno, R.; Oeyen, S.; Öhman, C. A.; Pinto, B. B.; Soliman, I. W.; Szczeklik, W.; Niederseer, D.; Valentin, A.; Watson, X.; Leaver, S.; Boulanger, C.; Walther, S.; Schefold, J. C.; Joannidis, M.; Nalapko, Y.; Elhadi, M.; Fjølner, J.; Zafeiridis, T.; De Lange, D. W.; Guidet, B.; Flaatten, H.; Jung, C. (Nature, 2021-07-05)

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