• Mild cognitive impairment: the Manchester consensus 

  Ballard, Clive (Silverchair, 2021-01-08)

  Given considerable variation in diagnostic and therapeutic practice, there is a need for national guidance on the use of neuroimaging, fluid biomarkers, cognitive testing, follow-up and diagnostic terminology in mild ...

• Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis 

  Jones, S. E.; Beaumont, Robin N.; Tyrrell, Jessica; Frayling, Timothy M.; Wood, A. R.; Weedon, M. N. (Silverchair, 2020-11-05)

  Background: It is established that Alzheimer's disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset ...

• Increased isoform-specific phosphodiesterase 4D expression is associated with pathology and cognitive impairment in Alzheimer's disease 

  Roubroeks, J.; Lunnon, Katie (Elsevier Science, 2021-01)

  Pharmacological phosphodiesterase 4D (PDE4D) inhibition shows therapeutic potential to restore memory function in Alzheimer's disease (AD), but will likely evoke adverse side effects. As PDE4D encodes multiple isoforms, ...

• Next-Generation RNA-Sequencing of Serum Small Extracellular Vesicles Discovers Potential Diagnostic Biomarkers for Dementia With Lewy Bodies 

  Ballard, Clive (Elsevier Science, 2021-06)

  Objective: There is an urgent clinical need for identifying blood-based diagnostic biomarkers for Dementia with Lewy Bodies (DLB). Transcriptomic studies have reported unique RNA changes in postmortem DLB brains. Small ...

• Isoform-specific upregulation of FynT kinase expression is associated with tauopathy and glial activation in Alzheimer's disease and Lewy body dementias 

  Ballard, Clive (Wiley, 2021-03)

  Cumulative data suggest the involvement of Fyn tyrosine kinase in Alzheimer's disease (AD). Previously, our group has shown increased immunoreactivities of the FynT isoform in AD neocortex (with no change in the alternatively ...

• Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis 

  Boulanger, Carole (Nature Publishing Group, 2020-10-29)

  Female and male very elderly intensive patients (VIPs) might differ in characteristics and outcomes. We aimed to compare female versus male VIPs in a large, multinational collective of VIPs with regards to outcome and ...

• Screening and Intervention to Prevent Falls and Fractures in Older People 

  Lamb, S. E.; Hulme, C; Sheridan, Ray (Atypon, 2020-11-05)

  Background: Community screening and therapeutic prevention strategies may reduce the incidence of falls in older people. The effects of these measures on the incidence of fractures, the use of health resources, and ...

• Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy 

  Atkins, J. L.; Pilling, L. C.; Masoli, Jane A.; Melzer, David (Silverchair, 2020-11-24)

  Importance: Hereditary hemochromatosis is predominantly caused by the HFE p.C282Y homozygous pathogenic variant. Liver carcinoma and mortality risks are increased in individuals with clinically diagnosed hereditary ...

• Sarcopenia and Variation in the Human Leukocyte Antigen Complex 

  Jones, Garan; Pilling, L. C.; Melzer, David (Oxford University Press, 2020-01-20)

  Background: Aging is characterized by chronic inflammation plus loss of muscle mass and strength, termed sarcopenia. Human leukocyte antigen (HLA) types are drivers of autoimmune disease, although with limited penetrance. ...

• Effects of Purified Anthocyanins in People at Risk for Dementia: Study Protocol for a Phase II Randomized Controlled Trial 

  Ballard, Clive (Frontiers Media SA, 2020-09-02)

  Background: The number of people with dementia is increasing, with huge challenges for society and health-care systems. There are no disease-modifying therapies available. There is, therefore, an urgent need to identify ...

• Agitation and impulsivity in mid and late life as possible risk markers for incident dementia 

  Ballard, Clive (PubMed Central, 2020-09-06)

  To identify knowledge gaps regarding new-onset agitation and impulsivity prior to onset of cognitive impairment or dementia the International Society to Advance Alzheimer's Research and Treatment Neuropsychiatric Syndromes ...

• FLAME: A computerized neuropsychological composite for trials in early dementia 

  Corbett, Anne; Creese, Byron; Ballard, Clive (PubMed Central, 2020-10-14)

  Introduction: Sensitive neuropsychological tests are needed to improve power for clinical trials in early Alzheimer's disease (AD). Methods: To develop a neuropsychological composite (FLAME - Factors of Longitudinal ...

• Tip of the Iceberg: Assessing the Global Socioeconomic Costs of Alzheimer's Disease and Related Dementias and Strategic Implications for Stakeholders 

  Ballard, Clive (IOS Press, 2019)

  While it is generally understood that Alzheimer's disease (AD) and related dementias (ADRD) is one of the costliest diseases to society, there is widespread concern that researchers and policymakers are not comprehensively ...

• Unmet needs, health policies, and actions during the COVID-19 pandemic: a report from six European countries 

  Hope, Suzy (PubMed Central, 2021-02)

  Purpose: The United Nations (UN) has published a Policy Brief on the impact of the Coronavirus Disease 2019 (COVID-19) that identifies policies and responses to protect older adults. Our objective was to summarize actions, ...

• Knowledge, skills and attitudes of older people and staff about getting up from the floor following a fall: a qualitative investigation 

  Hope, Suzy; Goodwin, V. A. (BioMed Central, 2020-10-06)

  Background: Falls are the most common reason for ambulance callouts resulting in non-conveyance. Even in the absence of injury, only half of those who fall can get themselves up off the floor, often remaining there over ...

• EuGMS 2019 Congress report: evidence-based medicine in geriatrics 

  Hope, Suzy (PubMed Central, 2020-12)

  The 2019 EuGMS Congress "Evidence-Based Medicine in Geriatrics" was held in Krakow, Poland, and attended by over 1600 participants from 64 different countries. A summary and reflection on the congress was presented in the ...

• Drug repositioning and repurposing for Alzheimer disease 

  Ballard, Clive; Corbett, Anne (Nature Publishing Group, 2020-12)

  Drug repositioning and repurposing can enhance traditional drug development efforts and could accelerate the identification of new treatments for individuals with Alzheimer disease (AD) dementia and mild cognitive impairment. ...

• Potentially inappropriate prescribing in dementia, multi-morbidity and incidence of adverse health outcomes 

  Ballard, Clive; Melzer, David; Jones, Lindsay; Delgado, J. (Oxford University Press, 2021-02-26)

  Importance: treatment of dementia in individuals with comorbidities is complex, leading to potentially inappropriate prescribing (PIP). The impact of PIP in this population is unknown. Objective: to estimate the rate ...

• The Incidence of Recorded Delirium Episodes Before and After Dementia Diagnosis: Differences Between Dementia With Lewy Bodies and Alzheimer's Disease 

  Ballard, Clive (Elsevier Science, 2019-05)

  Objectives: To describe the incidence of delirium recording before and after a diagnosis of dementia is established in patients with dementia with Lewy bodies (DLB) and compare findings to a matched cohort of patients with ...

• Evaluating enhanced recovery after surgery: time to cover new ground and discover the missing patient voice 

  Nunns, M.; John, Joseph; McGrath, John S; Briscoe, S.; Thompson Coon, J.; Lovegrove, Chris; Thomas, David; Anderson, R. (BioMed Central, 2020-09-14)

  Multicomponent peri-operative interventions offer to accelerate patient recovery and improve cost-effectiveness. The recent National Institute of Health Research-commissioned evidence synthesis review by Nunns et al. ...

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