• Calcium-channel blockers: Clinical outcome associations with reported pharmacogenetics variants in 32 000 patients 

  Türkmen, D.; Masoli, J. A. H.; Delgado, J.; Kuo, C. L.; Bowden, J.; Melzer, D.; Pilling, L. C. (Wiley, 2022-09-22)

  AIMS: Pharmacogenetic variants impact dihydropyridine calcium-channel blockers (dCCBs; e.g., amlodipine) treatment efficacy, yet evidence on clinical outcomes in routine primary care is limited. Reported associations in ...

• Overactive bladder: not just a normal part of getting older 

  Carpenter, L.; Campain, N. J. (Mark Allen Group, 2022-10-13)

  Overactive bladder (OAB) is a common yet under-reported condition affecting both men and women. Prevalence rises with age, but OAB can affect people of any age. It is associated with increased physical and mental health ...

• Genomics and multimorbidity 

  Masoli, J. A. H.; Pilling, L. C.; Frayling, T. M. (Oxford University Press, 2022-12-05)

  Multimorbidity has increased in prevalence world-wide. It is anticipated to affect over 1 in 6 of the UK population by 2035 and is now recognised as a global priority for health research. Genomic medicine has rapidly ...

• The role of sodium-glucose co-transporter-2 inhibitors in frail older adults with or without type 2 diabetes mellitus 

  Evans, M.; Morgan, A. R.; Davies, S.; Beba, H.; Strain, W. D. (Oxford University Press, 2022-10-06)

  Sodium-glucose co-transporter-2 (SGLT2) inhibitors offer significant outcome benefits beyond glucose lowering, including reduced risk of cardiovascular death, all-cause mortality, major adverse cardiovascular events, ...

• Is there an association between levonorgestrel-releasing intrauterine system and breast cancer risk? 

  Iavazzo, C.; Gkegkes, I. D. (Springer, 2022-10-19)

• Ultra-high-resolution time-frequency analysis of EEG to characterise brain functional connectivity with the application in Alzheimer's disease 

  Cao, J.; Zhao, Y.; Shan, X.; Blackburn, D.; Wei, J.; Erkoyuncu, J. A.; Chen, L.; Sarrigiannis, P. G. (IOP Publishing, 2022-08-11)

  Objective.This study aims to explore the potential of high-resolution brain functional connectivity based on electroencephalogram, a non-invasive low-cost technique, to be translated into a long-overdue biomarker and a ...

• Spatial-temporal graph convolutional network for Alzheimer classification based on brain functional connectivity imaging of electroencephalogram 

  Shan, X.; Cao, J.; Huo, S.; Chen, L.; Sarrigiannis, P. G.; Zhao, Y. (Wiley, 2022-06-25)

  Functional connectivity of the human brain, representing statistical dependence of information flow between cortical regions, significantly contributes to the study of the intrinsic brain network and its functional mechanism. ...

• Trajectories of cognitive change following stroke: stepwise decline towards dementia in the elderly 

  Delgado, J.; Masoli, J.; Hase, Y.; Akinyemi, R.; Ballard, C.; Kalaria, R. N.; Allan, L. M. (Oxford University Press , 2022-06-08)

  Stroke events increase the risk of developing dementia, 10% for a first-ever stroke and 30% for recurrent strokes. However, the effects of stroke on global cognition, leading up to dementia, remain poorly understood. We ...

• New horizons for caring for people with dementia in hospital: the DEMENTIA CARE pointers for service change 

  Abbott, R. A.; Rogers, M.; Lourida, I.; Green, C.; Ball, S.; Hemsley, A.; Cheeseman, D.; Clare, L.; Moore, D.; Hussey, C.; Coxon, G.; Llewellyn, D. J.; Naldrett, T.; Thompson Coon, J. (Oxford University Press, 2022-09-02)

  Approximately two-thirds of hospital admissions are older adults and almost half of these are likely to have some form of dementia. People with dementia are not only at an increased risk of adverse outcomes once admitted, ...

• Age and ageing cardiovascular collection: blood pressure, coronary heart disease and heart failure 

  Masoli, J. A. H.; Mensah, E.; Rajkumar, C. (Oxford University Press, 2022-08-02)

  As people age they are at increased risk of cardiovascular disease, the leading cause of mortality and morbidity worldwide. Understanding cardiovascular ageing is essential to preserving healthy ageing and preventing serious ...

• Hospital at Home admission avoidance with comprehensive geriatric assessment to maintain living at home for people aged 65 years and over: a RCT 

  Shepperd, S.; Cradduck-Bamford, A.; Butler, C.; Ellis, G.; Godfrey, M.; Gray, A.; Hemsley, A.; Khanna, P.; Langhorne, P.; Mäkelä, P.; Mort, S.; Ramsay, S.; Schiff, R.; Singh, S.; Smith, S.; Stott, D. J.; Tsiachristas, A.; Wilkinson, A.; Yu, L. M.; Young, J. (NIHR Journals Library, 2022-01-01)

  BACKGROUND: Evidence is required to guide the redesign of health care for older people who require hospital admission. OBJECTIVES: We assessed the clinical effectiveness and cost-effectiveness of geriatrician-led admission ...

• The Population-Wide Risk-Benefit Profile of Extending the Primary COVID-19 Vaccine Course Compared with an mRNA Booster Dose Program 

  Shiri, T.; Evans, M.; Talarico, C. A.; Morgan, A. R.; Mussad, M.; Buck, P. O.; McEwan, P.; Strain, W. D. (MDPI, 2022-01-18)

  The vaccination program is reducing the burden of COVID-19. However, recently, COVID-19 infections have been increasing across Europe, providing evidence that vaccine efficacy is waning. Consequently, booster doses are ...

• Is comprehensive geriatric assessment hospital at home a cost-effective alternative to hospital admission for older people? 

  Singh, S.; Gray, A.; Shepperd, S.; Stott, D. J.; Ellis, G.; Hemsley, A.; Khanna, P.; Ramsay, S.; Schiff, R.; Tsiachristas, A.; Wilkinson, A.; Young, J. (Oxford University Press, 2022-01-06)

  BACKGROUND: hospital level healthcare in the home guided by comprehensive geriatric assessment (CGA) might provide a less costly alternative to hospitalisation for older people. OBJECTIVE: to determine the cost-effectiveness ...

• Hypertension management in older patients-Are the guideline blood pressure targets appropriate? 

  Masoli, J. A. H.; Sheppard, J. P.; Rajkumar, C. (Oxford University Press, 2022-01-06)

• Telephone Interview for Cognitive Status Scores Associate with Cognitive Impairment and Alzheimer's Disease Pathology at Death 

  Robinson, A. C.; Davidson, Y. S.; Roncaroli, F.; Minshull, J.; Tinkler, P.; Cairns, M.; Horan, M. A.; Payton, A.; Mann, D. M. A. (IOS Press, 2021-11-09)

  BACKGROUND: Early diagnosis of Alzheimer's disease (AD) provides an opportunity for early intervention. Cognitive testing has proven to be a reliable way to identify individuals who may be at risk of AD. The Telephone ...

• The Value of Insulin Degludec in Frail Older Adults with Type 2 Diabetes 

  Strain, W. D.; Morgan, A. R.; Evans, M. (Springer, 2021-11-01)

  Insulin represents a mainstay of glucose-lowering therapy for many adults with type 2 diabetes mellitus (T2DM). Insulin treatments prescribed as standard care for the majority of people with T2DM, such as basal human ...

• Management and outcomes in critically ill nonagenarian versus octogenarian patients 

  Bruno, R. R.; Wernly, B.; Kelm, M.; Boumendil, A.; Morandi, A.; Andersen, F. H.; Artigas, A.; Finazzi, S.; Cecconi, M.; Christensen, S.; Faraldi, L.; Lichtenauer, M.; Muessig, J. M.; Marsh, B.; Moreno, R.; Oeyen, S.; Öhman, C. A.; Pinto, B. B.; Soliman, I. W.; Szczeklik, W.; Valentin, A.; Watson, X.; Leaver, S.; Boulanger, C.; Walther, S.; Schefold, J. C.; Joannidis, M.; Nalapko, Y.; Elhadi, M.; Fjølner, J.; Zafeiridis, T.; De Lange, D. W.; Guidet, B.; Flaatten, H.; Jung, C. (BioMed Central, 2021-10-19)

  BACKGROUND: Intensive care unit (ICU) patients age 90 years or older represent a growing subgroup and place a huge financial burden on health care resources despite the benefit being unclear. This leads to ethical problems. ...

• Blood pressure, frailty and dementia 

  Masoli, J. A. H.; Delgado, J. (Elsevier, 2021-09-16)

  High blood pressure (BP) affects 75% of people aged over 70. Ageing alters BP homeostasis, resulting in postural hypotension and increased BP variability. Co-morbidity and frailty add complexity to understanding BP changes ...

• Acute sarcopenia changes following hospitalization: influence of pre-admission care dependency level 

  De Spiegeleer, A.; Kahya, H.; Sanchez-Rodriguez, D.; Piotrowicz, K.; Surquin, M.; Marco, E.; Detremerie, C.; Hussein, D.; Hope, S.; Dallmeier, D.; Decker, G.; Hrnciarikova, D.; Czesak, J.; Toscano-Rico, M.; Meza-Valderrama, D.; Bahat, G.; Descamps, A.; Wynendaele, E.; Elewaut, D.; Vankova, H.; Landi, F.; Benoit, F.; Gasowski, J.; Van Den Noortgate, N. (Oxford University Press, 2021-08-09)

  INTRODUCTION: Hospitalization is associated with acute changes in sarcopenia status in older people, but the influencing factors are not fully understood. Pre-admission care dependency level as a risk factor has not yet ...

• Cerebral small vessel disease, systemic vascular characteristics and potential therapeutic targets 

  Elyas, S.; Adingupu, D. D.; Aizawa, K.; Casanova, F.; Gooding, K.; Fulford, J.; Mawson, D.; Gates, P. E.; Shore, A. C.; Strain, D. (Impact Journals, 2021-09-21)

  INTRODUCTION: Cerebral small vessel disease (SVD) is prevalent in the elderly population and is associated with increased risk of dementia, stroke and disability. Currently there are no clear targets or strategies for the ...

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