Now showing items 1-20 of 281

    • The lateral meniscus as a guide to anatomical tibial tunnel placement during anterior cruciate ligament reconstruction 

      Kassam, Al-Amin; Tillotson, Laura; Schranz, Peter J.; Mandalia, Vipul (Bentham Open, 2015)
      Purpose: The aim of the study is to show, on an MRI scan, that the posterior border of the anterior horn of the lateral meniscus (AHLM) could guide tibial tunnel position in the sagittal plane and provide anatomical graft ...
    • Levels of circulating microparticles in patients with chronic cardiorenal disease. 

      Chen, Y-L; Chen, C-H; Wallace, Christopher G; Wang, H-T; Yang, C-C; Yip, H-K (J-Stage, 2015)
      Cardiac and renal diseases are common disorders that frequently coexist. We tested the hypothesis that the levels of circulating endothelial-derived apoptotic microparticles (EDA-MPs; CD31(+)CD42b(-)AN(-)V(+)) and ...
    • Mandibular reconstruction 

      Wallace, Christopher G; Tsao, C. K.; Wei, F. C. (Wiley-Blackwell, 2015)
    • Scalp and calvarial reconstruction 

      Wallace, Christopher G; Wei, F. C. (Wiley, 2015)
    • Variable Phenotype of Diabetes Mellitus in Siblings with a Homozygous PTF1A Enhancer Mutation. 

      Gonc, E. N.; Ozon, A.; Alikasifoglu, A.; Haliloğlu, M.; Ellard, Sian; Shaw-Smith, Charles; Kandemir, N. (Karger, 2015)
      Neonatal diabetes is a rare form of diabetes, characterized by onset in the first 6 months of life. A number of cases are due to pancreas agenesis. Recently, PTF1A enhancer mutations have been shown to cause neonatal ...
    • Optimisation of an Advanced Oxidation Protein Products Assay: Its Application to Studies of Oxidative Stress in Diabetes Mellitus. 

      Taylor, E. L.; Armstrong, K. R.; Perrett, D.; Hattersley, Andrew T.; Winyard, Paul G. (Hindawi, 2015)
      Advanced oxidation protein products (AOPP) are reportedly elevated in the plasma of patients with a number of diseases, including diabetes mellitus, that involve oxidative stress. However, the accurate measurement of AOPP ...
    • Genotype and phenotype correlations in Iranian patients with hyperinsulinaemic hypoglycaemia. 

      Senniappan, S.; Sadeghizadeh, A.; Flanagan, Sarah; Ellard, Sian; Hashemipour, M.; Hosseinzadeh, M.; Salehi, M.; Hussain, K. (BioMed Central, 2015)
      Hyperinsulinaemic hypoglycaemia (HH) is a group of clinically and genetically heterogeneous disorders characterized by unregulated insulin secretion. Abnormalities in nine different genes (ABCC8, KCNJ11, GLUD1, GCK, HADH, ...
    • All blood counts: a manual for blood conservation and patient blood management 

      Thomas, D; Thompson, John F.; Ridler, Biddy (TFM Publishing, 2015)
    • Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. 

      Wessel, J. [et al]; Hattersley, Andrew T.; Frayling, Timothy M.; Yaghootkar, Hanieh (Nature, 2015-01)
      Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals ...
    • Increased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects. 

      Shi, Y.; Avatapalle, H. B.; Skae, M. S.; Padidela, R.; Newbould, M.; Rigby, L.; Flanagan, Sarah; Ellard, Sian; Rahier, J.; Clayton, P. E.; Dunne, M. J.; Banerjee, I.; Cosgrove, K. E. (Elsevier, 2015-01)
      Congenital hyperinsulinism causes profound hypoglycemia, which may persist or resolve spontaneously. Among 13 children with congenital hyperinsulinism, elevated incretin hormone concentrations were detected in 2 with ...
    • Biological interpretation of genome-wide association studies using predicted gene functions. 

      Pers, T. H.; Karjalainen, J.M.; Chan, Y.; Westra, H-J; Wood, A. R.; Yang, J; Lui, J. C.; Vedantam, S.; Gustafsson, S.; Esko, T.; Frayling, Timothy M.; Speliotes, E. K.; Boehnke, M.; Raychaudhuri, S.; Fehrmann, R. S. N.; Hirschhorn, J. N.; Franke, L.; Hattersley, Andrew T. (Nature, 2015-01)
      The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions ...
    • Use of a pathway quality improvement care bundle to reduce mortality after emergency laparotomy. 

      Huddart, S; Peden, C J; Swart, M; McCormick, Bruce; Dickinson, M; Mohammed, M A; Quiney, N (Wiley, 2015-01)
      Emergency laparotomies in the U.K., U.S.A. and Denmark are known to have a high risk of death, with accompanying evidence of suboptimal care. The emergency laparotomy pathway quality improvement care (ELPQuiC) bundle is ...
    • Evaluation of the results of management of frozen shoulder using the arthroscopic capsular release 

      Mubark, Islam M.; Ragab, A. H.; Nagi, A. A.; Motawea, B. A. (Ortop Traumatol Rehabil, 2015-01-01)
      BACKGROUND: The aim of treatment of frozen shoulder is to regain a painless and functional shoulder range of shoulder motion. In this study we evaluated the results of using the arthroscopic technique for the release of ...
    • A role for panendoscopy? Second primary tumour in early stage squamous cell carcinoma of the oral tongue 

      Koo, K.; Harris, Robert; Wiesenfeld, D.; Iseli, T. A. (Cambridge Journals, 2015-01-01)
      BACKGROUND: Panendoscopy is routinely used for the identification of occult second primary tumours in head and neck squamous cell carcinoma. However, its role in low risk subgroups, particularly non-smoking, non-drinking ...
    • An unusual case of an ACTH-secreting macroadenoma with a germline variant in the aryl hydrocarbon receptor-interacting protein (AIP) gene 

      Dinesen, P. T.; Dal, J.; Gabrovska, P.; Gaustadnes, M.; Gravholt, C. H.; Stals, Karen; Denes, J.; Asa, S. L.; Korbonits, M.; Jorgensen, J. O. (Endocrinol Diabetes Metab Case Reports, 2015-01-01)
      A patient of Cushing's disease (CD) characterized by a large tumor and only subtle symptoms of hormonal hypersecretion was examined. The patient had a germline variant in the aryl hydrocarbon receptor-interacting protein ...
    • The quality of intensive care unit nurse handover related to end of life: a descriptive comparative international study 

      Ganz, F. D.; Endacott, R.; Chaboyer, W.; Benbinishty, J.; Ben Nun, M.; Ryan, H.; Schoter, Amanda; Boulanger, Carole; Chamberlain, W.; Spooner, A. (Elsevier, 2015-01-01)
      BACKGROUND: Quality ICU end-of-life-care has been found to be related to good communication. Handover is one form of communication that can be problematic due to lost or omitted information. A first step in improving care ...
    • Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers 

      Peterlongo, P.; Chang-Claude, J.; Moysich, K. B.; Rudolph, A.; Schmutzler, R. K.; Simard, J.; Soucy, P.; Eeles, R. A.; Easton, D. F.; Hamann, U.; Wilkening, S.; Chen, B.; Rookus, M. A.; Schmidt, M. K.; van der Baan, F. H.; Spurdle, A. B.; Walker, L. C.; Lose, F.; Maia, A. T.; Montagna, M.; Matricardi, L.; Lubinski, J.; Jakubowska, A.; Gomez Garcia, E. B.; Olopade, O. I.; Nussbaum, R. L.; Nathanson, K. L.; Domchek, S. M.; Rebbeck, T. R.; Arun, B. K.; Karlan, B. Y.; Orsulic, S.; Lester, J.; Chung, W. K.; Miron, A.; Southey, M. C.; Goldgar, D. E.; Buys, S. S.; Janavicius, R.; Dorfling, C. M.; van Rensburg, E. J.; Ding, Y. C.; Neuhausen, S. L.; Hansen, T. V.; Gerdes, A. M.; Ejlertsen, B.; Jonson, L.; Osorio, A.; Martinez-Bouzas, C.; Benitez, J.; Conway, E. E.; Blazer, K. R.; Weitzel, J. N.; Manoukian, S.; Peissel, B.; Zaffaroni, D.; Scuvera, G.; Barile, M.; Ficarazzi, F.; Mariette, F.; Fortuzzi, S.; Viel, A.; Giannini, G.; Papi, L.; Martayan, A.; Tibiletti, M. G.; Radice, P.; Vratimos, A.; Fostira, F.; Garber, J. E.; Donaldson, A.; Brewer, Carole; Foo, C.; Evans, D. G.; Frost, D.; Eccles, D.; Brady, A.; Cook, J.; Tischkowitz, M.; Adlard, J.; Barwell, J.; Walker, L.; Izatt, L.; Side, L. E.; Kennedy, M. J.; Rogers, M. T.; Porteous, M. E.; Morrison, P. J.; Platte, R.; Davidson, R.; Hodgson, S. V.; Ellis, S.; Cole, T.; Embrace,; Godwin, A. K.; Claes, K.; Van Maerken, T.; Meindl, A.; Gehrig, A.; Sutter, C.; Engel, C.; Niederacher, D.; Steinemann, D.; Plendl, H.; Kast, K.; Rhiem, K.; Ditsch, N.; Arnold, N.; Varon-Mateeva, R.; Wappenschmidt, B.; Wang-Gohrke, S.; Bressac-de Paillerets, B.; Buecher, B.; Delnatte, C.; Houdayer, C.; Stoppa-Lyonnet, D.; Damiola, F.; Coupier, I.; Barjhoux, L.; Venat-Bouvet, L.; Golmard, L.; Boutry-Kryza, N.; Sinilnikova, O. M.; Caron, O.; Pujol, P.; Mazoyer, S.; Belotti, M.; Gemo Study Collaborators; Piedmonte, M.; Friedlander, M. L.; Rodriguez, G. C.; Copeland, L. J.; de la Hoya, M.; Segura, P. P.; Nevanlinna, H.; Aittomaki, K.; van Os, T. A.; Meijers-Heijboer, H. E.; van der Hout, A. H.; Vreeswijk, M. P.; Hoogerbrugge, N.; Ausems, M. G.; van Doorn, H. C.; Collee, J. M.; Hebon,; Olah, E.; Diez, O.; Blanco, I.; Lazaro, C.; Brunet, J.; Feliubadalo, L.; Cybulski, C.; Gronwald, J.; Durda, K.; Jaworska-Bieniek, K.; Sukiennicki, G.; Arason, A.; Chiquette, J.; Teixeira, M. R.; Olswold, C.; Couch, F. J.; Lindor, N. M.; Wang, X.; Szabo, C. I.; Offit, K.; Corines, M.; Jacobs, L.; Robson, M. E.; Zhang, L.; Joseph, V.; Berger, A.; Singer, C. F.; Rappaport, C.; Kaulich, D. G.; Pfeiler, G.; Tea, M. K.; Phelan, C. M.; Greene, M. H.; Mai, P. L.; Rennert, G.; Mulligan, A. M.; Glendon, G.; Tchatchou, S.; Andrulis, I. L.; Toland, A. E.; Bojesen, A.; Pedersen, I. S.; Thomassen, M.; Jensen, U. B.; Laitman, Y.; Rantala, J.; von Wachenfeldt, A.; Ehrencrona, H.; Askmalm, M. S.; Borg, A.; Kuchenbaecker, K. B.; McGuffog, L.; Barrowdale, D.; Healey, S.; Lee, A.; Pharoah, P. D.; Chenevix-Trench, G.; K. ConFab Investigators; Antoniou, A. C.; Friedman, E. (Cancer Epidemiol Biomarkers Prev, 2015-01-01)
      BACKGROUND: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same ...
    • COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity 

      McCulloch, Laura J.; Rawling, T. J.; Sjoholm, K.; Franck, N.; Dankel, S. N.; Price, E. J.; Knight, Bridget; Liversedge, Neil H.; Mellgren, G.; Nystrom, F.; Carlsson, L. M.; Kos, K. (Endocrine Society, 2015-01-01)
      Fibrosis of adipose tissue (AT) increases AT rigidity, reduces its expandability, and contributes to metabolic dysfunction. Collagen type VI, alpha3 (COL6A3) encodes 1 subunit of a fibrotic extracellular matrix protein ...
    • Surgical retraction tabs: sparing the skin in skin sparing mastectomy 

      Taha, Hischam M.; Ferguson, Douglas (Elsevier, 2015-01-01)
    • The "ischial limb": a landmark on anterior ultrasound scanning used to assess reduction in developmental dysplasia of the hip 

      Woodacre, Timothy; Carlile, G. S.; Cox, Peter J. (Wolters Kluwer, 2015-01-01)
      BACKGROUND: Early recognition of failure of reduction during abduction splinting in developmental dysplasia of the hip (DDH) is essential to avoid inappropriate prolonged damaging harness use. Graf ultrasound scanning (USS) ...