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EDTA improves stability of whole blood C-peptide and insulin to over 24 hours at room temperature.
(PLoS One, 2012)C-peptide and insulin measurements in blood provide useful information regarding endogenous insulin secretion. Conflicting evidence on sample stability and handling procedures continue to limit the widespread clinical use ... -
Identifying good responders to glucose lowering therapy in type 2 diabetes: implications for stratified medicine.
(PLoS, 2014)Defining responders to glucose lowering therapy can be important for both clinical care and for the development of a stratified approach to diabetes management. Response is commonly defined by either HbA1c change after ... -
The impact of insulin administration during the mixed meal tolerance test.
(Wiley, 2012-10)The mixed meal tolerance test is the gold standard measure of endogenous insulin secretion. Practical issues limit the routine clinical use of this test, including omitting insulin prior to the ingestion of a high-carbohydrate ... -
Home urine C-peptide creatinine ratio (UCPCR) testing can identify type 2 and MODY in pediatric diabetes.
(Wiley, 2013-05)Making the correct diabetes diagnosis in children is crucial for lifelong management. Type 2 diabetes and maturity onset diabetes of the young (MODY) are seen in the pediatric setting, and can be difficult to discriminate ... -
The impact of gender on urine C-peptide creatinine ratio interpretation.
(Sage, 2012-07)Urinary C-peptide creatinine ratio (UCPCR) is a non-invasive and convenient way of assessing endogenous insulin production. Adjusting for urine creatinine levels allows for differences in urine concentration. Creatinine ... -
Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin.
(BioMed Central, 2012)In patients with both Type 1 and Type 2 diabetes endogenous insulin secretion falls with time which changes treatment requirements, however direct measurement of endogenous insulin secretion is rarely performed. We aimed ... -
Use of HbA1c in the identification of patients with hyperglycaemia caused by a glucokinase mutation: observational case control studies.
(PLoS One, 2013)HaemoglobinA1c (HbA1c) is recommended for diabetes diagnosis but fasting plasma glucose (FPG) has been useful for identifying patients with glucokinase (GCK) mutations which cause lifelong persistent fasting hyperglycaemia. ... -
Maturity-onset diabetes of the young (MODY): how many cases are we missing?
(Springer, 2010-12)Maturity-onset diabetes of the young is frequently misdiagnosed as type 1 or type 2 diabetes. A correct diagnosis of MODY is important for determining treatment, but can only be confirmed by molecular genetic testing. We ... -
Assessment of the HNF1B Score as a Tool to Select Patients for HNF1B Genetic Testing.
(Karger, 2015-05-22)Diagnosing hepatocyte nuclear factor 1β (HNF1B)-related disease is a challenging task due to the phenotypic variability and frequent absence of a family history. An HNF1B score has recently been developed to help select ... -
Effect of the holiday season in patients with diabetes: glycemia and lipids increase postholiday, but the effect is small and transient.
(American Diabetes Association, 2014)