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Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide
(Nature, 2017-01-03)Major depressive disorder (MDD) represents a major social and economic health issue and constitutes a major risk factor for suicide. The molecular pathology of suicidal depression remains poorly understood, although it has ... -
Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1.
(Nature, 2016-06-07)Exposure to adverse rearing environments including institutional deprivation and severe childhood abuse is associated with an increased risk for mental and physical health problems across the lifespan. Although the mechanisms ... -
An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication.
(Taylor & Francis, 2016)Prenatal maternal stress exposure has been associated with neonatal differential DNA methylation. However, the available evidence in humans is largely based on candidate gene methylation studies, where only a few CpG sites ... -
Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions
(Oxford Journals, 2016-12-22)Genetic association studies provide evidence for a substantial polygenic component to schizophrenia, although the neurobiological mechanisms underlying the disorder remain largely undefined. Building on recent studies ... -
On Picturing a Candle: The Prehistory of Imagery Science.
(Frontiers In Psychology, 2016-04-07)The past 25 years have seen a rapid growth of knowledge about brain mechanisms involved in visual mental imagery. These advances have largely been made independently of the long history of philosophical - and even psychological ... -
Paternal Age Alters Social Development in Offspring.
(Elsevier, 2017-05)Advanced paternal age (APA) at conception has been linked with autism and schizophrenia in offspring, neurodevelopmental disorders that affect social functioning. The current study explored the effects of paternal age on ... -
Meta-analysis of epigenome-wide association studies of cognitive abilities.
(Nature, 2018-01-08)Cognitive functions are important correlates of health outcomes across the life-course. Individual differences in cognitive functions are partly heritable. Epigenetic modifications, such as DNA methylation, are susceptible ... -
Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study.
(Nature, 2017-02)Attention-deficit/hyperactivity disorder (ADHD) is a prevalent developmental disorder, associated with a range of long-term impairments. Variation in DNA methylation, an epigenetic mechanism, is implicated in both ... -
Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood.
(American Psychiatric Association, 2018-01-12)DNA methylation has been proposed as an epigenetic mechanism by which early-life experiences become "embedded" in the genome and alter transcriptional processes to compromise health. The authors sought to investigate whether ... -
Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology.
(Elsevier, 2018-03-14)Alzheimer's disease is a neurodegenerative disorder that is hypothesized to involve epigenetic dysregulation of gene expression in the brain.