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Is treatment-resistant schizophrenia categorically distinct from treatment-responsive schizophrenia? a systematic review.
(BioMed Central, 2017-01-13)Schizophrenia is a highly heterogeneous disorder, and around a third of patients are treatment-resistant. The only evidence-based treatment for these patients is clozapine, an atypical antipsychotic with relatively weak ... -
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
(Nature, 2018-05)Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and ... -
Peripheral DNA methylation, cognitive decline and brain aging: pilot findings from the Whitehall II imaging study.
(Future Medicine, 2018-05)The present study investigated the link between peripheral DNA methylation (DNAm), cognitive impairment and brain aging. -
Prenatal immune activation alters the adult neural epigenome but can be partly stabilised by a n-3 polyunsaturated fatty acid diet.
(Nature, 2018-07-02)An unstable epigenome is implicated in the pathophysiology of neurodevelopmental disorders such as schizophrenia and autism. This is important because the epigenome is potentially modifiable. We have previously reported ... -
Sex-specific transcription and DNA methylation profiles of reproductive and epigenetic associated genes in the gonads and livers of breeding zebrafish.
(Elsevier, 2018-08)Reproduction is an essential process for life and is regulated by complex hormone networks and environmental factors. To date, little is known about the contribution of epigenetic mechanisms to the regulation of reproduction, ... -
Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's Disease
(Nature, 2019-10)Psychosis (delusions or hallucinations) in Alzheimer's disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for ... -
Alzheimer's Disease associated genes ankyrin and tau cause shortened lifespan and memory loss in Drosophila
(Open Access Frontiers, 2019-06)Alzheimer's disease (AD) is the most common form of dementia and is characterized by intracellular neurofibrillary tangles of hyperphosphorylated Tau, including the 0N4R isoform and accumulation of extracellular amyloid ... -
Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences
(Nature, 2019-02)Childhood psychotic experiences (PEs), such as seeing or hearing things that others do not, or extreme paranoia, are relatively common with around 1 in 20 children reporting them at age 12. Childhood PEs are often distressing ... -
The Mental and Physical Health of Older Adults With a Genetic Predisposition for Autism
(Wiley, 2020-04)Autism commonly aggregates in families, with twin studies estimating heritability to be around 80%. Subclinical autism-like characteristics have also been found at elevated rates in relatives of autistic probands. Physical ... -
Temporal Relationship Between Depressive Symptoms and Cognition in Mid and Late Life: A Longitudinal Cohort Study
(Elsevier Science, 2020-08)Objectives: To examine the bidirectional temporal relationship between depressive symptoms and cognition in relation to risk, reaction, and prodrome. Design: Cross-lag analysis of longitudinal data collected online at ...