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The role of perfusion in the oxygen extraction capability of skin and skeletal muscle.
(American Physiological Society, 2016-05-15)Oxygen extraction (OE) by all cells is dependent on an adequate supply of oxygen in proximal blood vessels and the cell's need and ability to uptake that oxygen. Here the role of blood flow in regulating OE in skin and ... -
Echogenicity of the Common Carotid Artery Intima-Media Complex in Stroke.
(Elsevier, 2016-03-01)The grey-scale median of the common carotid artery intima-media complex (IM-GSM) characterizes arterial wall composition, and a low IM-GSM is associated with increased cardiovascular mortality in the elderly. We aimed to ... -
Prevalence of systolic inter-arm differences in blood pressure for different primary care populations: systematic review and meta-analysis.
(Royal College of General Practitioners, 2016-11)Various prevalence figures have been reported for inter-arm differences in blood pressure (IAD); variation may be explained by differing population vascular risk and by measurement method. -
Rapid infrared mapping for highly accurate automated histology in Barrett's oesophagus.
(Royal Society of Chemistry, 2016-10-07)Barrett's oesophagus (BE) is a premalignant condition that can progress to oesophageal adenocarcinoma. Endoscopic surveillance aims to identify potential progression at an early, treatable stage, but generates large numbers ... -
The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control.
(BioMed Central, 2017-09-15)Good glycaemic control in type 2 diabetes (T2DM) protects the microcirculation. Current guidelines suggest glycaemic targets be relaxed in advanced diabetes. We explored whether disease duration or pre-existing macrovascular ... -
Clinical effectiveness and cost-effectiveness of the Rehabilitation Enablement in Chronic Heart Failure (REACH-HF) facilitated self-care rehabilitation intervention in heart failure patients and caregivers: rationale and protocol for a multicentre randomised controlled trial.
(BMJ, 2015-12-23)The Rehabilitation EnAblement in CHronic Heart Failure (REACH-HF) trial is part of a research programme designed to develop and evaluate a health professional facilitated, home-based, self-help rehabilitation intervention ... -
Diagnostic accuracy of high-definition CT coronary angiography in high-risk patients.
(Elsevier, 2016-02)To assess the diagnostic accuracy of computed tomography coronary angiography (CTCA) using a combination of high-definition CT (HD-CTCA) and high level of reader experience, with invasive coronary angiography (ICA) as the ... -
Hyaluronidase 2 deficiency is a molecular cause of cor triatriatum sinister in mice.
(Elsevier, 2016-02-10) -
Inter-arm blood pressure difference and mortality: a cohort study in an asymptomatic primary care population at elevated cardiovascular risk.
(Royal College of General Practitioners, 2016-04-14)Differences in blood pressure between arms are associated with increased cardiovascular mortality in cohorts with established vascular disease or substantially elevated cardiovascular risk.