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Diagnostic accuracy of high-definition CT coronary angiography in high-risk patients.

Iyengar, S S; Morgan-Hughes, G; Ukoumunne, O; Clayton, B; Davies, E J; Nikolaou, V; Hyde, C J; Shore, Angela; Roobottom, C A (Elsevier, 2016-02)
To assess the diagnostic accuracy of computed tomography coronary angiography (CTCA) using a combination of high-definition CT (HD-CTCA) and high level of reader experience, with invasive coronary angiography (ICA) as the ...
Clinical effectiveness and cost-effectiveness of the Rehabilitation Enablement in Chronic Heart Failure (REACH-HF) facilitated self-care rehabilitation intervention in heart failure patients and caregivers: rationale and protocol for a multicentre randomised controlled trial.

Taylor, R S; Hayward, C; Eyre, V; Austin, J; Davies, R; Doherty, P; Jolly, K; Wingham, J; Van Lingen, R; Abraham, C; Green, C; Warren, F C; Britten, Nicky; Greaves, C J; Singh, S; Buckingham, S; Paul, K; Dalal, H (BMJ, 2015-12-23)
The Rehabilitation EnAblement in CHronic Heart Failure (REACH-HF) trial is part of a research programme designed to develop and evaluate a health professional facilitated, home-based, self-help rehabilitation intervention ...
Maternal hypothyroxinaemia in pregnancy is associated with obesity and adverse maternal metabolic parameters.

Knight, Bridget A.; Shields, Beverley M; Hattersley, Andrew T.; Vaidya, Bijay (BioScientifica, 2016-01)
Subclinical hypothyroidism and isolated hypothyroxinaemia in pregnancy have been associated with an increased risk of gestational diabetes. We aimed to ascertain if these women have a worse metabolic phenotype than euthyroid ...
Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model.

Spiers, H; Hannon, Eilis; Wells, S; Williams, B; Fernandes, C; Mill, Jonathan (Elsevier, 2016-02-06)
Epigenetic disruption has been implicated in many diseases of aging, and age-associated DNA methylation changes at specific genomic loci in humans are strongly correlated with chronological age. The aim of this study was ...
Whole exome sequence analysis reveals a homozygous mutation in PNPLA2 as the cause of severe dilated cardiomyopathy secondary to neutral lipid storage disease

Muggenthaler, Martina; Petropoulou, E.; Omer, S.; Simpson, M.A.; Sahak, H.; Rice, A.; Raju, H.; Conti, F.J.; Bridges, L.R.; Anderson, L.J.; Sharma, S.; Behr, E.R.; Jamshidi, Y. (Elsevier, 2016-02-13)
Measurement properties of multidimensional patient-reported outcome measures in neurodisability: a systematic review of evaluation studies.

Janssens, A.; Rogers, M.; Gumm, Rebecca; Jenkinson, C.; Tennant, A.; Logan, Stuart; Morris, Christopher (Wiley, 2015-12-11)
To identify and appraise the quality of studies that primarily assessed the measurement properties of English language versions of multidimensional patient-reported outcome measures (PROMs) when evaluated with children ...
Tranexamic acid in major trauma: implementation and evaluation across South West England

Paudyal, P.; Smith, J.; Robinson, M.; South, A.; Higginson, I.; Reuben, Adam; Shaffee, J.; Black, S.; Logan, Stuart (Wolters Kluwer, 2015-08-26)
OBJECTIVE: To carry out a prospective evaluation of tranexamic acid (TXA) use in trauma patients. PATIENTS AND METHODS: TXA was introduced to all emergency ambulances and emergency departments in the South West, UK, on 1 ...
A comparison of methods for EGFR mutation testing in non-small cell lung cancer.

Young, Elizabeth C.; Owens, Martina; Adebiyi, I; Bedenham, T; Butler, R; Callaway, J; Cranston, T; Crosby, C; Cree, I A; Dutton, L; Faulkes, C; Faulkner, C; Howard, E; Knight, J; Huang, Y; Lavender, L; Lazarou, L P; Liu, H; Mair, D; Milano, A; Sandell, S; Skinner, A; Wallace, A; Williams, M. V.; Spivey, V; Goodall, J; Frampton, J; Ellard, Sian (Wolters Kluwer, 2013-12)
EGFR mutation testing of tumor samples is routinely performed to predict sensitivity to treatment with tyrosine kinase inhibitors for patients with non-small cell lung cancer. At least 9 different methodologies are employed ...
Hyaluronidase 2 deficiency is a molecular cause of cor triatriatum sinister in mice.

Chowdhury, B.; Xiang, B.; Muggenthaler, Martina; Dolinsky, V. W.; Triggs-Raine, B. (Elsevier, 2016-02-10)
Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight.

Tyrrell, J.; Richmond, R. C.; Palmer, T. M.; Feenstra, B.; Rangarajan, J.; Metrustry, S.; Cavadino, A.; Paternoster, L.; Armstrong, L. L.; De Silva, N. M. G.; Wood, A. R.; Horikoshi, M.; Geller, F.; Myhre, R.; Bradfield, J. P.; Kreiner-Møller, E.; Huikari, V.; Painter, J. N.; Hottenga, J.J.; Allard, C.; Berry, D. J.; Bouchard, L.; Das, S.; Evans, D. M.; Hakonarson, H.; Hayes, M. G.; Heikkinen, J.; Hofman, A.; Knight, B.; Lind, P. A.; McCarthy, M. I.; McMahon, G.; Medland, S. E.; Melbye, M.; Morris, A. P.; Nodzenski, M.; Reichetzeder, C.; Ring, S. M.; Sebert, S.; Sengpiel, V.; Sørensen, T. I. A.; Willemsen, G.; de Geus, E. J. C.; Martin, N. G.; Spector, T. D.; Power, C.; Järvelin, M.-R.; Bisgaard, H.; Grant, S. F. A.; Nohr, E. A.; Jaddoe, V. W.; Jacobsson, B.; Murray, J. C.; Hocher, B.; Hattersley, Andrew T.; Scholtens, D. M.; Davey Smith, G.; Hivert, M.-F.; Felix, J. F.; Hyppönen, E.; Lowe, W. L.; Frayling, T. M.; Lawlor, D. A.; Freathy, Rachel M. (JAMA, 2016-03-15)
Neonates born to overweight or obese women are larger and at higher risk of birth complications. Many maternal obesity-related traits are observationally associated with birth weight, but the causal nature of these ...

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