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Raman spectroscopy and multivariate analysis for the non invasive diagnosis of clinically inconclusive vulval lichen sclerosus.
(Royal Society of Chemistry, 2016-11-09)Vulval lichen sclerosus (LS) is a common inflammatory condition associated with an increased risk of developing vulval carcinoma. Diagnosis is usually clinical although biopsy is necessary if the diagnosis is uncertain or ... -
Developing fibre optic Raman probes for applications in clinical spectroscopy.
(Royal Society of Chemistry, 2016-04-07)Raman spectroscopy has been shown by various groups over the last two decades to have significant capability in discriminating disease states in bodily fluids, cells and tissues. Recent development in instrumentation, ... -
Relationships between pathology and crystal structure in breast calcifications: an in situ X-ray diffraction study in histological sections
(Nature, 2016-09-14)Calcifications are not only one of the most important early diagnostic markers of breast cancer, but are also increasingly believed to aggravate the proliferation of cancer cells and invasion of surrounding tissue. Moreover, ... -
Mirrored stainless steel substrate provides improved signal for Raman spectroscopy of tissue and cells.
(Wiley, 2017-01)Raman spectroscopy (RS) is a powerful technique that permits the non-destructive chemical analysis of cells and tissues without the need for expensive and complex sample preparation. To date, samples have been routinely ... -
Towards new material biomarkers for fracture risk.
(Elsevier, 2016-12)Osteoporosis is a prevalent bone condition, characterised by low bone mass and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of ... -
Temperature Spatially Offset Raman Spectroscopy (T-SORS): Subsurface Chemically Specific Measurement of Temperature in Turbid Media Using Anti-Stokes Spatially Offset Raman Spectroscopy.
(American Chemical Society, 2016-01-05)Here we propose and demonstrate a new analytical method for the noninvasive measurement of subsurface temperatures within diffusely scattering (turbid) media in combination with high chemical selectivity. The method is ... -
Exploring the effect of laser excitation wavelength on signal recovery with deep tissue transmission Raman spectroscopy.
(Royal Society of Chemistry, 2016-10-21)The aim of this research was to find the optimal Raman excitation wavelength to attain the largest possible sensitivity in deep Raman spectroscopy of breast tissue. This involved careful consideration of factors such as ... -
Using Raman spectroscopy to characterize biological materials.
(Nature, 2016-04)Raman spectroscopy can be used to measure the chemical composition of a sample, which can in turn be used to extract biological information. Many materials have characteristic Raman spectra, which means that Raman spectroscopy ... -
Towards the intra-operative use of Raman spectroscopy in breast cancer-overcoming the effects of theatre lighting.
(Springer, 2016-08)The ability to use Raman spectroscopy to assess tissue in the operative theatre setting could be advantageous for both patients and clinicians. In this study, a method of overcoming the deleterious effects of theatre ... -
Classification of fracture and non-fracture groups by analysis of coherent X-ray scatter.
(Nature, 2016-07-01)Osteoporotic fractures present a significant social and economic burden, which is set to rise commensurately with the aging population. Greater understanding of the physicochemical differences between osteoporotic and ...