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Performance of mid infrared spectroscopy in skin cancer cell type identification
(SPIE, 2017-02-17)Marker free optical spectroscopy is a powerful tool for the rapid inspection of pathologically suspicious skin lesions and the non-invasive detection of early skin tumors. This goal can be reached by the combination of ... -
Mirrored stainless steel substrate provides improved signal for Raman spectroscopy of tissue and cells.
(Wiley, 2017-01)Raman spectroscopy (RS) is a powerful technique that permits the non-destructive chemical analysis of cells and tissues without the need for expensive and complex sample preparation. To date, samples have been routinely ... -
Raman spectroscopy and multivariate analysis for the non invasive diagnosis of clinically inconclusive vulval lichen sclerosus.
(Royal Society of Chemistry, 2016-11-09)Vulval lichen sclerosus (LS) is a common inflammatory condition associated with an increased risk of developing vulval carcinoma. Diagnosis is usually clinical although biopsy is necessary if the diagnosis is uncertain or ... -
Developing fibre optic Raman probes for applications in clinical spectroscopy.
(Royal Society of Chemistry, 2016-04-07)Raman spectroscopy has been shown by various groups over the last two decades to have significant capability in discriminating disease states in bodily fluids, cells and tissues. Recent development in instrumentation, ... -
Relationships between pathology and crystal structure in breast calcifications: an in situ X-ray diffraction study in histological sections
(Nature, 2016-09-14)Calcifications are not only one of the most important early diagnostic markers of breast cancer, but are also increasingly believed to aggravate the proliferation of cancer cells and invasion of surrounding tissue. Moreover, ... -
Using Raman spectroscopy to characterize biological materials.
(Nature, 2016-04)Raman spectroscopy can be used to measure the chemical composition of a sample, which can in turn be used to extract biological information. Many materials have characteristic Raman spectra, which means that Raman spectroscopy ... -
Towards the intra-operative use of Raman spectroscopy in breast cancer-overcoming the effects of theatre lighting.
(Springer, 2016-08)The ability to use Raman spectroscopy to assess tissue in the operative theatre setting could be advantageous for both patients and clinicians. In this study, a method of overcoming the deleterious effects of theatre ... -
High-resolution FTIR imaging of colon tissues for elucidation of individual cellular and histopathological features.
(Royal Society of Chemistry, 2016-01-21)Novel technologies that could complement current histopathology based cancer diagnostic methods are under examination. In this endeavour mid-infrared spectroscopic imaging is a promising candidate that can provide valuable ... -
Classification of fracture and non-fracture groups by analysis of coherent X-ray scatter.
(Nature, 2016-07-01)Osteoporotic fractures present a significant social and economic burden, which is set to rise commensurately with the aging population. Greater understanding of the physicochemical differences between osteoporotic and ... -
Clinical applications of infrared and Raman spectroscopy: state of play and future challenges.
(Royal Society of Chemistry, 2018-04-16)Vibrational spectroscopies, based on infrared absorption and/or Raman scattering provide a detailed fingerprint of a material, based on the chemical content. Diagnostic and prognostic tools based on these technologies have ...