Now showing items 1-20 of 2953

    • Association of age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer 

      D'Andrea, D.; Black, P. C.; Zargar, H.; Zargar-Shoshtari, K.; Soria, F.; Fairey, A. S.; Mertens, L. S.; Dinney, C. P.; Mir, M. C.; Krabbe, L. M.; Cookson, M. S.; Jacobsen, N. E.; Montgomery, J. S.; Vasdev, N.; Yu, E. Y.; Xylinas, E.; Campain, N. J.; Kassouf, W.; Dall'Era, M. A.; Seah, J. A.; Ercole, C. E.; Horenblas, S.; Sridhar, S. S.; McGrath, J. S.; Aning, J.; Wright, J. L.; Thorpe, A. C.; Morgan, T. M.; Holzbeierlein, J. M.; Bivalacqua, T. J.; North, S.; Barocas, D. A.; Lotan, Y.; Grivas, P.; Stephenson, A. J.; Shah, J. B.; van Rhijn, B. W.; Daneshmand, S.; Spiess, P. E.; Shariat, S. F. (Springer, 2021-08-09)
      PURPOSE: To assess the association of patient age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer (MIBC). MATERIALS AND METHODS: We analyzed data from 1105 patients with MIBC. ...
    • Impact of arteriovenous fistulas versus arteriovenous grafts on vascular access performance in haemodialysis patients: A systematic review and meta-analysis 

      Hajibandeh, S.; Burton, H.; Gleed, P.; Hajibandeh, S.; Wilmink, T. (SAGE, 2021-08-31)
      BACKGROUND: Controversy exists regarding the best-performing vascular access type for patients undergoing haemodialysis. We aimed to compare outcomes of starting dialysis on arteriovenous fistulas (AVFs) versus arteriovenous ...
    • Genetic association study of childhood aggression across raters, instruments, and age 

      Ip, H. F.; van der Laan, C. M.; Krapohl, E. M. L.; Brikell, I.; Sánchez-Mora, C.; Nolte, I. M.; St Pourcain, B.; Bolhuis, K.; Palviainen, T.; Zafarmand, H.; Colodro-Conde, L.; Gordon, S.; Zayats, T.; Aliev, F.; Jiang, C.; Wang, C. A.; Saunders, G.; Karhunen, V.; Hammerschlag, A. R.; Adkins, D. E.; Border, R.; Peterson, R. E.; Prinz, J. A.; Thiering, E.; Seppälä, I.; Vilor-Tejedor, N.; Ahluwalia, T. S.; Day, F. R.; Hottenga, J. J.; Allegrini, A. G.; Rimfeld, K.; Chen, Q.; Lu, Y.; Martin, J.; Soler Artigas, M.; Rovira, P.; Bosch, R.; Español, G.; Ramos Quiroga, J. A.; Neumann, A.; Ensink, J.; Grasby, K.; Morosoli, J. J.; Tong, X.; Marrington, S.; Middeldorp, C.; Scott, J. G.; Vinkhuyzen, A.; Shabalin, A. A.; Corley, R.; Evans, L. M.; Sugden, K.; Alemany, S.; Sass, L.; Vinding, R.; Ruth, K.; Tyrrell, J.; Davies, G. E.; Ehli, E. A.; Hagenbeek, F. A.; De Zeeuw, E.; Van Beijsterveldt, Tcem; Larsson, H.; Snieder, H.; Verhulst, F. C.; Amin, N.; Whipp, A. M.; Korhonen, T.; Vuoksimaa, E.; Rose, R. J.; Uitterlinden, A. G.; Heath, A. C.; Madden, P.; Haavik, J.; Harris, J. R.; Helgeland, Ø; Johansson, S.; Knudsen, G. P. S.; Njolstad, P. R.; Lu, Q.; Rodriguez, A.; Henders, A. K.; Mamun, A.; Najman, J. M.; Brown, S.; Hopfer, C.; Krauter, K.; Reynolds, C.; Smolen, A.; Stallings, M.; Wadsworth, S.; Wall, T. L.; Silberg, J. L.; Miller, A.; Keltikangas-Järvinen, L.; Hakulinen, C.; Pulkki-Råback, L.; Havdahl, A.; Magnus, P.; Raitakari, O. T.; Perry, J. R. B.; Llop, S.; Lopez-Espinosa, M. J.; Bønnelykke, K.; Bisgaard, H.; Sunyer, J.; Lehtimäki, T.; Arseneault, L.; Standl, M.; Heinrich, J.; Boden, J.; Pearson, J.; Horwood, L. J.; Kennedy, M.; Poulton, R.; Eaves, L. J.; Maes, H. H.; Hewitt, J.; Copeland, W. E.; Costello, E. J.; Williams, G. M.; Wray, N.; Järvelin, M. R.; McGue, M.; Iacono, W.; Caspi, A.; Moffitt, T. E.; Whitehouse, A.; Pennell, C. E.; Klump, K. L.; Burt, S. A.; Dick, D. M.; Reichborn-Kjennerud, T.; Martin, N. G.; Medland, S. E.; Vrijkotte, T.; Kaprio, J.; Tiemeier, H.; Davey Smith, G.; Hartman, C. A.; Oldehinkel, A. J.; Casas, M.; Ribasés, M.; Lichtenstein, P.; Lundström, S.; Plomin, R.; Bartels, M.; Nivard, M. G.; Boomsma, D. I. (Nature, 2021-07-30)
      Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from ...
    • Prosthetic joint infection of the knee - arthroscopic biopsy identifies more and different organisms than aspiration alone 

      Clarke, M. J. H.; Salar, O.; Evans, J. P.; Bayley, M. G. R.; Waterson, B. H.; Toms, A. D.; Phillips, J. R. A. (Elsevier, 2021-09-06)
      BACKGROUND: Prosthetic joint infection (PJI) causes significant morbidity and mortality following knee replacement surgery. Identifying causative organisms and antibiotic sensitivities is critical in increasing the chance ...
    • Nonepithelial ovarian cancers 

      Baker-Rand, Holly; Edey, Katharine (Wiley, 2021-06-07)
      Key content Nonepithelial ovarian cancers (NEOCs) are rare forms of ovarian cancer, including malignant ovarian germ cell tumours (MOGCTs), sex cord-stromal tumours (SCSTs) and ovarian sarcoma. Tumour markers including ...
    • Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression 

      Võsa, U.; Claringbould, A.; Westra, H. J.; Bonder, M. J.; Deelen, P.; Zeng, B.; Kirsten, H.; Saha, A.; Kreuzhuber, R.; Yazar, S.; Brugge, H.; Oelen, R.; de Vries, D. H.; van der Wijst, M. G. P.; Kasela, S.; Pervjakova, N.; Alves, I.; Favé, M. J.; Agbessi, M.; Christiansen, M. W.; Jansen, R.; Seppälä, I.; Tong, L.; Teumer, A.; Schramm, K.; Hemani, G.; Verlouw, J.; Yaghootkar, H.; Sönmez Flitman, R.; Brown, A.; Kukushkina, V.; Kalnapenkis, A.; Rüeger, S.; Porcu, E.; Kronberg, J.; Kettunen, J.; Lee, B.; Zhang, F.; Qi, T.; Hernandez, J. A.; Arindrarto, W.; Beutner, F.; Dmitrieva, J.; Elansary, M.; Fairfax, B. P.; Georges, M.; Heijmans, B. T.; Hewitt, A. W.; Kähönen, M.; Kim, Y.; Knight, J. C.; Kovacs, P.; Krohn, K.; Li, S.; Loeffler, M.; Marigorta, U. M.; Mei, H.; Momozawa, Y.; Müller-Nurasyid, M.; Nauck, M.; Nivard, M. G.; Penninx, Bwjh; Pritchard, J. K.; Raitakari, O. T.; Rotzschke, O.; Slagboom, E. P.; Stehouwer, C. D. A.; Stumvoll, M.; Sullivan, P.; t Hoen, P. A. C.; Thiery, J.; Tönjes, A.; van Dongen, J.; van Iterson, M.; Veldink, J. H.; Völker, U.; Warmerdam, R.; Wijmenga, C.; Swertz, M.; Andiappan, A.; Montgomery, G. W.; Ripatti, S.; Perola, M.; Kutalik, Z.; Dermitzakis, E.; Bergmann, S.; Frayling, T.; van Meurs, J.; Prokisch, H.; Ahsan, H.; Pierce, B. L.; Lehtimäki, T.; Boomsma, D. I.; Psaty, B. M.; Gharib, S. A.; Awadalla, P.; Milani, L.; Ouwehand, W. H.; Downes, K.; Stegle, O.; Battle, A.; Visscher, P. M.; Yang, J.; Scholz, M.; Powell, J.; Gibson, G.; Esko, T.; Franke, L. (Nature, 2021-09-01)
      Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on the transcriptome. To investigate the genetics of gene expression, we performed cis- and trans-expression quantitative trait ...
    • Covid-19 vaccine-induced antibodies are attenuated and decay rapidly in infliximab treated patients 

      Simeng, Lin; Nicholas, A. Kennedy; Aamir, Saifuddin; Diana Muñoz, Sandoval; Catherine, Reynolds; Rocio Castro, Seoane; Sherine, Kottoor; Franziska, Pieper; Kai-Min, Lin; David, K. Butler; Neil, Chanchlani; Rachel, Nice; Desmond, Chee; Claire, Bewshea; Malik, Janjua; Timothy, J. McDonald; Shaji, Sebastian; James, L. Alexander; Laura, Constable; James, C. Lee; Charles, D. Murray; Ailsa, L. Hart; Peter, M. Irving; Gareth-Rhys, Jones; Klaartje, B. Kok; Christopher, A. Lamb; Charlie, W. Lees; Daniel, M. Altmann; Rosemary, J. Boyton; James, R. Goodhand; Nick, Powell; Tariq, Ahmad (Unknown, 2021-09-27)
      To inform healthcare policy for immunosuppressed patients there is a need to define SARS-CoV-2 vaccine responses. Here we report SARS-CoV-2 vaccine-induced antibody and T cell responses in patients treated with anti-tumour ...
    • Global parental leave in surgical careers: differences according to gender, geographical regions and surgical career stages 

      Au, S.; Bellato, V.; Carvas, J. M.; Córdoba, C. D.; Daudu, D.; Dziakova, J.; Eltarhoni, K.; El Feituri, N.; Fung, A. C. H.; Fysaraki, C.; Gallo, G.; Gultekin, F. A.; Harbjerg, J. L.; Hatem, F.; Ioannidis, A.; Jakobsen, L.; Clinch, D.; Kristensen, HØ; Kuiper, S. Z.; Kwok, A. M. F.; Kwok, W.; Millan, M.; Milto, K. M.; Ng, H. J.; Pellino, G.; Picciariello, A.; Pronin, S.; van Ramshorst, G. H.; Ramser, M.; Jiménez-Rodríguez, R. M.; Sainz Hernandez, J. C.; Samadov, E.; Sohrabi, S.; Uchiyama, M.; Wang, J. H.; Younis, M. U.; Fleming, S.; Alhomoud, S.; Mayol, J.; Moeslein, G.; Smart, N. J.; Soreide, K.; Teh, C.; Verran, D.; Maeda, Y. (Wiley, 2021-09-01)
      BACKGROUND: There is a lack of information regarding the provision of parental leave for surgical careers. This survey study aims to evaluate the experience of maternity/paternity leave and views on work-life balance ...
    • FUNCTIONAL OUTCOMES OF PELVIC OSTEOTOMIES FOR HIP DYSPLASIA: A STUDY USING THE UK NON-ARTHROPLASTY HIP REGISTRY (NAHR) DATASET 

      R, Holleyman; MA, Sohatee; M, Bankes; J, Witt; T, Andrade; T, Board; C, McBryde; J, Conroy; M, Wilson; V, Khanduja; A, Malviya (British Editorial Society of Bone and Joint Journal, 2021-08-19)
      Pelvic re-orientation osteotomy is a well-recognised treatment of young adults with developmental dysplasia of the hip (DDH). The most commonly used technique is the periacetabular osteotomy (PAO), however, some surgeons ...
    • CEMENT-IN-CEMENT REVISION OF THE FEMUR IN THE INFECTED HIP ARTHROPLASTY 

      W, Fishley; V, Selvaratnam; I, Carluke; P, Partington; M, Reed; D, Kramer; M, Wilson; M, Hubble; J, Howell; A, Timperley; S, Whitehouse; AA, Kassam; T, Petheram (British Editorial Society of Bone and Joint Journal, 2021-08-19)
      Femoral cement-in-cement revision is a well described technique to reduce morbidity and complications in hip revision surgery. Traditional techniques for septic revision necessitate removal of all bone cement from the ...
    • EARLY OUTCOMES OF SURGERY FOR FEMOROACETABULAR IMPINGEMENT: A STUDY USING THE UK NON-ARTHROPLASTY REGISTRY (NAHR) DATASET 

      R, Holleyman; MA, Sohatee; M, Bankes; T, Andrade; C, McBryde; T, Board; J, Conroy; M, Wilson; A, Malviya; V, Khanduja (British Editorial Society of Bone and Joint Journal, 2021-08-19)
      FAI may cause pain or functional impairment for an individual, as well as potentially resulting in arthritis and degeneration of the hip joint. Results from recent randomised control trials demonstrate the superiority of ...
    • Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score 

      Unknown author (Wiley, 2021-07-06)
      To support the global restart of elective surgery, data from an international prospective cohort study of 8492 patients (69 countries) was analysed using artificial intelligence (machine learning techniques) to develop a ...
    • Anakinra for palmoplantar pustulosis: results from a randomized, double-blind, multicentre, two staged, adaptive placebo controlled trial (APRICOT) 

      Cro, S.; Cornelius, V. R.; Pink, A. E.; Wilson, R.; Pushpa-Rajah, A.; Patel, P.; Abdul-Wahab, A.; August, S.; Azad, J.; Becher, G.; Chapman, A.; Dunnil, G.; Ferguson, A. D.; Fogo, A.; Ghaffar, S. A.; Ingram, J. R.; Kavakleiva, S.; Ladoyanni, E.; Leman, J. A.; Macbeth, A. E.; Makrygeoegou, A.; Parslew, R.; Ryan, A. J.; Sharma, A.; Shipman, A. R.; Sinclair, C.; Wachsmuth, R.; Woolf, R. T.; Wright, A.; McAteer, H.; Barker, Jnwn; Burden, A. D.; Griffiths, C. E. M.; Reynolds, N. J.; Warren, R. B.; Lachmann, H. J.; Capon, F.; Smith, C. H. (Wiley, 2021-08-19)
      BACKGROUND: Palmoplantar pustulosis (PPP) is a rare, debilitating, chronic inflammatory skin disease affecting the hands and feet. Clinical, immunological and genetic findings suggest a pathogenic role for interleukin ...
    • Minimal Invasive Myomectomy with Morcellation for Giant Myoma: A Challenge or a Questionable Approach? 

      Iavazzo, C.; Gkegkes, I. D. (The Korean Society of Menopause., 2021-08-01)
      This study aimed to discuss the possible role of morcellation for a giant myoma in the minimal invasive approach. Current literature, including U.S. Food and Drug Administration guidelines, was reviewed. We found that ...
    • Identifying the Optimal Number of Neoadjuvant Chemotherapy Cycles in Patients with Muscle Invasive Bladder Cancer 

      D'Andrea, D.; Black, P. C.; Zargar, H.; Dinney, C. P.; Soria, F.; Cookson, M. S.; Montgomery, J. S.; Kassouf, W.; Dall'Era, M. A.; Sridhar, S. S.; McGrath, J. S.; Wright, J. L.; Thorpe, A. C.; Holzbeierlein, J. M.; Carrión, D. M.; Di Trapani, E.; Bivalacqua, T. J.; North, S.; Barocas, D. A.; Lotan, Y.; Grivas, P.; Stephenson, A. J.; van Rhijn, B. W.; Daneshmand, S.; Spiess, P. E.; Shariat, S. F. (Lippincott, Williams & Wilkins, 2021-08-27)
      PURPOSE: We investigated the pathological response rates and survival associated with 3 vs 4 cycles of cisplatin-based neoadjuvant chemotherapy (NAC) in patients with cT2-4N0M0 muscle invasive bladder cancer. MATERIALS AND ...
    • Impact of COVID-19 and other infectious conditions requiring isolation on the provision of and adaptations to fundamental nursing care in hospital in terms of overall patient experience, care quality, functional ability, and treatment outcomes: systematic review 

      Whear, R.; Abbott, R. A.; Bethel, A.; Richards, D. A.; Garside, R.; Cockcroft, E.; Iles-Smith, H.; Logan, P. A.; Rafferty, A. M.; Shepherd, M.; Sugg, H. V. R.; Russell, A. M.; Cruickshank, S.; Tooze, S.; Melendez-Torres, G. J.; Thompson Coon, J. (Wiley, 2021-08-23)
      AIM: This systematic review identifies, appraises and synthesizes the evidence on the provision of fundamental nursing care to hospitalized patients with a highly infectious virus and the effectiveness of adaptations to ...
    • Can Preoperative Characteristics Predict the Outcomes of Laparoscopic Cholecystectomy? 

      Orabi, A.; Di Mauro, D.; Njere, I.; Ratano, M.; Thavakumar, S.; Reece-Smith, A.; Wajed, S.; Manzelli, A. (Mary Ann Liebert, 2021-08-06)
      Background: Intraoperative findings during laparoscopic cholecystectomy (LC) are highly unpredictable and operative difficulty varies from straightforward to very challenging procedures. Several studies described predictors ...
    • Guided tissue regeneration techniques involving blood-derived products in periradicular surgery: a systematic review and meta-analysis protocol 

      Baniulyte, G.; Ali, K.; Burns, L. (Lippincott, Williams & Wilkins, 2021-08-13)
      OBJECTIVE: The objective of this review is to evaluate the clinical outcomes of standard periradicular surgery versus periradicular surgery with the use of guided tissue regeneration techniques involving blood-derived ...
    • Minimal Invasive Myomectomy with Morcellation for Giant Myoma: A Challenge or a Questionable Approach? 

      Iavazzo, C.; Gkegkes, I. D. (The Korean Society of Menopause., 2021-08-01)
      This study aimed to discuss the possible role of morcellation for a giant myoma in the minimal invasive approach. Current literature, including U.S. Food and Drug Administration guidelines, was reviewed. We found that ...
    • Delineating the molecular and phenotypic spectrum of the SETD1B-related syndrome 

      Weerts, M. J. A.; Lanko, K.; Guzmán-Vega, F. J.; Jackson, A.; Ramakrishnan, R.; Cardona-Londoño, K. J.; Peña-Guerra, K. A.; van Bever, Y.; van Paassen, B. W.; Kievit, A.; van Slegtenhorst, M.; Allen, N. M.; Kehoe, C. M.; Robinson, H. K.; Pang, L.; Banu, S. H.; Zaman, M.; Efthymiou, S.; Houlden, H.; Järvelä, I.; Lauronen, L.; Määttä, T.; Schrauwen, I.; Leal, S. M.; Ruivenkamp, C. A. L.; Barge-Schaapveld, Dqcm; Peeters-Scholte, Cmpcd; Galehdari, H.; Mazaheri, N.; Sisodiya, S. M.; Harrison, V.; Sun, A.; Thies, J.; Pedroza, L. A.; Lara-Taranchenko, Y.; Chinn, I. K.; Lupski, J. R.; Garza-Flores, A.; McGlothlin, J.; Yang, L.; Huang, S.; Wang, X.; Jewett, T.; Rosso, G.; Lin, X.; Mohammed, S.; Merritt, J. L., 2nd; Mirzaa, G. M.; Timms, A. E.; Scheck, J.; Elting, M. W.; Polstra, A. M.; Schenck, L.; Ruzhnikov, M. R. Z.; Vetro, A.; Montomoli, M.; Guerrini, R.; Koboldt, D. C.; Mosher, T. M.; Pastore, M. T.; McBride, K. L.; Peng, J.; Pan, Z.; Willemsen, M.; Koning, S.; Turnpenny, P. D.; de Vries, B. B. A.; Gilissen, C.; Pfundt, R.; Lees, M.; Braddock, S. R.; Klemp, K. C.; Vansenne, F.; van Gijn, M. E.; Quindipan, C.; Deardorff, M. A.; Hamm, J. A.; Putnam, A. M.; Baud, R.; Walsh, L.; Lynch, S. A.; Baptista, J.; Person, R. E.; Monaghan, K. G.; Crunk, A.; Keller-Ramey, J.; Reich, A.; Elloumi, H. Z.; Alders, M.; Kerkhof, J.; McConkey, H.; Haghshenas, S.; Maroofian, R.; Sadikovic, B.; Banka, S.; Arold, S. T.; Barakat, T. S. (Nature, 2021-08-03)
      PURPOSE: Pathogenic variants in SETD1B have been associated with a syndromic neurodevelopmental disorder including intellectual disability, language delay, and seizures. To date, clinical features have been described for ...