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The design and development of a complex multifactorial falls assessment intervention for falls prevention: The Prevention of Falls Injury Trial (PreFIT).

Bruce, J.; Ralhan, S.; Sheridan, Ray; Westacott, K.; Withers, E.; Finnegan, S.; Davison, J.; Martin, F. C.; Lamb, S. E. (BioMed Central, 2017-06-01)
This paper describes the design and development of a complex multifactorial falls prevention (MFFP) intervention for implementation and testing within the framework of a large UK-based falls prevention randomised controlled ...
Prophylactic radiotherapy for the prevention of procedure-tract metastases after surgical and large-bore pleural procedures in malignant pleural mesothelioma (SMART): a multicentre, open-label, phase 3, randomised controlled trial.

Clive, A. O.; Taylor, H.; Dobson, L.; Wilson, P.; de Winton, E.; Panakis, N.; Pepperell, J.; Howell, T.; Stewart, S. A.; Penz, E.; Jordan, N.; Morley, A. J.; Zahan-Evans, N.; Smith, S.; Batchelor, T. J. P.; Marchbank, A.; Bishop, L.; Ionescu, A. A.; Bayne, M.; Cooper, S.; Kerry, A.; Jenkins, P.; Toy, Elizabeth; Vigneswaran, V.; Gildersleve, J.; Ahmed, M.; McDonald, F.; Button, M.; Lewanski, C.; Comins, C.; Dakshinamoorthy, M.; Lee, Y. C. G.; Rahman, N. M.; Maskell, N. A. (Elsevier, 2016-06-23)
The use of prophylactic radiotherapy to prevent procedure-tract metastases (PTMs) in malignant pleural mesothelioma remains controversial, and clinical practice varies worldwide. We aimed to compare prophylactic radiotherapy ...
Truncating SLC5A7 mutations underlie a spectrum of dominant hereditary motor neuropathies.

Salter, C. G. [et al] inc.; Baple, Emma L.; Crosby, Andrew H. (Wolters Kluwer, 2018-04)
To identify the genetic cause of disease in 2 previously unreported families with forms of distal hereditary motor neuropathies (dHMNs).
Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.

Thwaites, G. E.; Scarborough, M.; Szubert, A.; Nsutebu, E.; Tilley, R.; Greig, J.; Wyllie, S. A.; Wilson, P.; Auckland, Cressida; Cairns, J.; Ward, D.; Lal, P.; Guleri, A.; Jenkins, N.; Sutton, J.; Wiselka, M.; Armando, G-R; Graham, C.; Chadwick, P. R.; Barlow, G.; Gordon, N. C.; Young, B.; Meisner, S.; McWhinney, P.; Price, D. A.; Harvey, D.; Nayar, D.; Jeyaratnam, D.; Planche, T.; Minton, J.; Hudson, F.; Hopkins, S.; Williams, J.; Török, M. E.; Llewelyn, M. J.; Edgeworth, J. D.; Walker, A. S. (Elsevier, 2017-12-14)
Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed ...
Xenogeneic human umbilical cord-derived mesenchymal stem cells reduce mortality in rats with acute respiratory distress syndrome complicated by sepsis.

Lee, F-Y; Chen, K-H; Wallace, Christopher G; Sung, P-H; Sheu, J-J; Chung, S-Y; Chen, Y-L; Lu, H-I; Ko, S-F; Sun, C-K; Chiang, H-J; Chang, H-W; Lee, M S; Yip, H-K (Oncotarget, 2017-07-11)
This study tested the hypothesis that xenogeneic human umbilical cord-derived mesenchymal stem cell (HUCDMSC) therapy would improve survival rates in rats with acute respiratory distress-syndrome (ARDS, induction by 48 h ...
Socioeconomic disparities in first stroke incidence, quality of care, and survival: a nationwide registry-based cohort study of 44 million adults in England.

Bray, B. D.; Paley, L.; Hoffman, A.; James, Martin; Gompertz, P.; Wolfe, C. D. A.; Hemingway, H.; Rudd, A. G. (Elsevier, 2018-04)
We aimed to estimate socioeconomic disparities in the incidence of hospitalisation for first-ever stroke, quality of care, and post-stroke survival for the adult population of England.
Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardias (REVERT): a randomised controlled trial

Appelboam, Andrew; Reuben, Adam; Mann, C.; Gagg, J.; Ewings, P.; Barton, A.; Lobban, T.; Dayer, M.; Vickery, J.; Benger, J.; Revert trial collaborators (Elsevier, 2015-10-31)
BACKGROUND: The Valsalva manoeuvre is an internationally recommended treatment for supraventricular tachycardia, but cardioversion is rare in practice (5-20%), necessitating the use of other treatments including adenosine, ...
The BRASS ( BReast Angiosarcoma Surveillance Study): Protocol for a retrospective multicentre cohort study to evaluate the management and outcomes of angiosarcoma of the breast and chest wall

Banks, Jenny; Ives, Charlotte; Potter, S.; Holcombe, C. (Elsevier, 2017-05-22)
Clinical evaluation of silicone gel in the treatment of cleft lip scars.

Chang, C-S; Wallace, Christopher G; Hsiao, Y-C; Huang, J-J; Chen, Z-C; Chang, C-J; Lo, L-J; Chen, P. K-T; Chen, J-P; Chen, Y-R (Nature, 2018-05-09)
Upper lip scars are at risk of hypertrophy. Our center therefore uses microporous tape and silicone sheeting for postoperative scar care following cleft lip repair. However, some babies have previously ingested their ...
Discovery of a novel dominant mutation in the REN gene after forty years of renal disease: a case report.

Clissold, Rhian L.; Clarke, H. C.; Spasic-Boskovic, O.; Brugger, K.; Abbs, S.; Bingham, Coralie; Shaw-Smith, Charles (BioMed Central, 2017-07-12)
Heterozygous mutations in the gene encoding renin (REN) cause autosomal dominant tubulointerstitial kidney disease (ADTKD), early-onset anaemia and hyperuricaemia; only four different mutations have been described in the ...

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