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Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model.
(Elsevier, 2016-02-06)Epigenetic disruption has been implicated in many diseases of aging, and age-associated DNA methylation changes at specific genomic loci in humans are strongly correlated with chronological age. The aim of this study was ... -
Rapid Down-Regulation of Glucocorticoid Gene Expression in the Dentate Gyrus after Acute Stress in vivo: Role of DNA Methylation and microRNA Activity.
(Karger, 2016-04-08)Although glucocorticoid receptors (GRs) in the hippocampus play a vital role in the regulation of physiological and behavioural responses to stress, the regulation of receptor expression remains unclear. This work investigates ... -
Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection.
(Nature, 2016-08-03)The potential for epigenetic changes in host cells following microbial infection has been widely suggested, but few examples have been reported. We assessed genome-wide patterns of DNA methylation in human macrophage-like ... -
An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation.
(BioMed Central, 2016-08-30)Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by episodic psychosis and altered cognitive function. Despite success in identifying genetic variants associated with schizophrenia, there remains ... -
Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain.
(Elsevier, 2016-11)Although mutations within the TREM2 gene have been robustly associated with Alzheimer's disease, it is not known whether alterations in the regulation of this gene are also involved in pathogenesis. Here, we present data ... -
Epigenetics in health and disease: heralding the EWAS era
(Elsevier, 2014-06-07) -
Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2.
(Wiley, 2016-02)Peripheral epigenetic marks hold promise for understanding psychiatric illness and may represent fingerprints of gene-environment interactions. We conducted an initial examination of CpG methylation variation in children ... -
Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies.
(Elsevier, 2016-06-20)The field of mitochondrial epigenetics has received increased attention in recent years and changes in mitochondrial DNA (mtDNA) methylation has been implicated in a number of diseases, including neurodegenerative diseases ... -
Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci.
(Nature, 2016-01)We characterized DNA methylation quantitative trait loci (mQTLs) in a large collection (n = 166) of human fetal brain samples spanning 56-166 d post-conception, identifying >16,000 fetal brain mQTLs. Fetal brain mQTLs were ... -
Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus.
(2016-04-26)Stressful events evoke long-term changes in behavioral responses; however, the underlying mechanisms in the brain are not well understood. Previous work has shown that epigenetic changes and immediate-early gene (IEG) ...