• Prospective evaluation of an ultrathin strut biodegradable polymer-coated sirolimus-eluting stent: 12 months' results from the S-FLEX UK registry 

  Sharp, Andrew (BMJ, 2019-10)

  OBJECTIVE: To prospectively evaluate safety and efficacy of the ultrathin strut biodegradable polymer-coated Supraflex sirolimus-eluting stent (S-SES) in 'real world' patient population requiring percutaneous coronary ...

• HLA-DQA1*05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's Disease 

  Kennedy, Nicholas A.; Heap, Graham; Bewshea, Claire M.; Chanclani, Neil; Walker, Gareth J.; Perry, Mandy H.; McDonald, Timothy J.; Goodhand, James R.; Ahmad, Tariq (Elsevier, 2020-01)

  Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The ability to ...

• Determination of inclusion depth in ex vivo animal tissues using surface enhanced deep Raman spectroscopy 

  Stone, Nick (Wiley, 2020-01)

  This work presents recent developments in spatially offset and transmission Raman spectroscopy for noninvasive detection and depth prediction of a single SERS inclusion located deep inside ex vivo biological tissues. The ...

• Diagnostic genetic testing for monogenic diabetes and congenital hyperinsulinemia 

  Houghton, Jane A. L. (Springer, 2020-01)

  Monogenic diabetes and hyperinsulinism are genetically heterogeneous disorders. The determination of the genetic etiology defines the diagnostic subtype, predicts prognosis, and importantly can guide clinical management. ...

• Measuring the effectiveness of safety warnings on the risk of stroke in older antipsychotic users: a nationwide cohort study in two large electronic medical records databases in the United Kingdom and Italy 

  Ballard, Clive (Springer, 2019-12)

  Safety warnings relating to antipsychotic-associated stroke among older persons in the UK and Italy were issued. However, the impact of these safety warnings on stroke risk has not been measured to date.

• Unravelling the genetic causes of mosaic islet morphology in congenital hyperinsulinism 

  Houghton, Jane A. L. (Wiley, 2019-10-02)

  Congenital hyperinsulinism (CHI) causes dysregulated insulin secretion which can lead to life-threatening hypoglycaemia if not effectively managed. CHI can be sub-classified into three distinct groups: diffuse, focal and ...

• Metaphyseal sleeves in revision total knee arthoplasty provide reliable fixation and excellent medium to long-term implant survivorship 

  Phillips, Jonathan R. (Elsevier, 2020-02)

  Addressing bone loss and securing implant fixation can be challenging in revision total knee arthroplasty (TKA). We present the results of a large series of revision TKAs using a metaphyseal sleeve.

• Video vs direct laryngoscopy: success rates and confidence: a feasibility study 

  Bartle, David G.; Powell, Roy; Pearson, Katie; Adeboye, Teniola S. (Stansted News Limited, 2019-09)

  Video-assisted laryngoscopy (VL) is being used increasingly in adult, paediatric and neonatal populations although its use has not been extensively studied in a neonatal setting. The authors’ experiences on the neonatal ...

• The Exeter Knee Infection Multi Disciplinary Team approach to managing prosthetic knee infections: A qualitative analysis 

  Awad, Fady; Searle, David; Walmsley, Katie; Dyar, Nadine; Auckland, Cressida; Bethune, Rob; Eyres, Keith; Phillips, Jonathan (Elsevier, 2019-09)

  A Knee Infection Multi-Disciplinary Team meeting was established in Exeter. This study was designed to qualitatively evaluate the impact of the MDT on those involved.

• Palliative care in liver disease: what does good look like? 

  Hudson, Ben (BMJ, 2019-09)

  The mortality rate from chronic liver disease in the UK is rising rapidly, and patients with advanced disease have a symptom burden comparable to or higher than that experienced in other life-limiting illnesses. While ...

• Safety in the clinical environment 

  Weekes, Lauren (Cambridge University Press, 2019)

• Association of elevated fractional exhaled nitric oxide concentration and blood eosinophil count with severe asthma exacerbations 

  Halpin, David M. (Biomed Central, 2019-08)

  Blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship of BEC and ...

• Practice pattern variability in the management of acute severe colitis: a UK provider survey 

  Kennedy, Nicholas A. (BMJ, 2019-08)

  Lack of comparative trial data on dosing regimens of infliximab in patients with acute severe ulcerative colitis (ASUC) failing intravenous corticosteroids has resulted in variability of rescue regimes in ASUC with potential ...

• Reply: intraoperative tissue perfusion measurement by laser speckle imaging: a potential aid for reducing postoperative complications in free flap breast reconstruction 

  To, Cynthia; Gooding, Kim; Cawrse, Nicholas H; Shore, Angela; Wilson, Andrew D (American Society of Plastic Surgeons, 2019-11)

• Airway management of patients with life threatening haemorrhage: principles of safe and effective care 

  Hudson, Tony (Springer, 2019-08)

  Airway care of the patient with life threatening haemorrhage presents many challenges during damage control resuscitation. The essential requirements are to maintain oxygenation at all stages of care and when necessary ...

• Decreased tibial nerve movement in patients with failed back surgery syndrome and persistent leg pain 

  Shum, G; Hutton, Mike; Chan, Daniel; Chauhan, Rohan (Springer, 2019-07)

  Purpose To measure and compare the total and normalised tibial nerve movements during forward bending in patients with and without failed back surgery syndrome (FBSS) and persistent leg pain following anatomically successful ...

• Perseverative negative thinking predicts depression in people with acute coronary syndrome 

  Gandhi, Manish (Elsevier, 2019-11)

  Depression is common in people who have experienced recent Acute Coronary Syndrome (ACS), and predicts worse medical outcomes. Mechanisms underpinning the development of depression and its association with poor medical ...

• Vaginal microbiota and human papillomavirus: a systematic review 

  Gkegkes, Ioannis D. (Galenos, 2019-09)

  Accumulating evidence indicates the potential correlation between the vaginal microbioma and the acquisition and persistence of Human Papillomavirus (HPV) infection. This study has as intention to demonstrate the potential ...

• Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years 

  McDonald, Timothy; Oram, Richard; Weedon, Michael; Hattersley, Andrew T.; Jones, Angus (BMJ, 2019-09)

  OBJECTIVE: To develop and validate multivariable clinical diagnostic models to assist distinguishing between type 1 and type 2 diabetes in adults aged 18-50. DESIGN: Multivariable logistic regression analysis was used ...

• British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults 

  Kennedy, Nicholas A. (BMJ, 2019-12)

  Ulcerative colitis and Crohn's disease are the principal forms of inflammatory bowel disease. Both represent chronic inflammation of the gastrointestinal tract, which displays heterogeneity in inflammatory and symptomatic ...

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