All RD&E publications by year
Browse by
This community lists all the RD&E research outputs, collated by year of publication/issue. You can browse the collections, by year, on the left-hand side of the screen.
Collections in this community
Recent Submissions
-
Quantification of Thigh Muscle Volume in Children and Adolescents Using Magnetic Resonance Imaging
(Taylor & Francis, 2020-01-12)Estimating muscle volume (MV) using variable numbers of cross-sectional area (CSA) slices obtained from magnetic resonance imaging (MRI) introduces an error that is known in adults, but not in children and adolescents, ... -
Generating evidence for new high-risk medical devices.
(BMJ, 2019-09-04) -
No Surgical Innovation Without Evaluation: Evolution and Further Development of the IDEAL Framework and Recommendations
(Wolters Kluwer, 2019-02)Abstract Objective: To update, clarify, and extend IDEAL concepts and recommendations. Background: New surgical procedures, devices, and other complex interventions need robust evaluation for safety, efficacy, and ... -
Royal Devon & Exeter NHS Foundation Trust publications - by specialty 2019
(Royal Devon & Exeter NHS Foundation Trust, 2020-06) -
Royal Devon & Exeter NHS Foundation Trust publications 2019
(Royal Devon & Exeter NHS Foundation Trust, 2020-06) -
Neuropsychological Assessment of mTBI in Adults
(Springer, 2019-11)Mild traumatic brain injury (mTBI), comprising 70–80% of all TBIs, is the commonest form of TBI, representing those injuries deemed to be at the lower end of the severity spectrum. In the general population, mTBI may occur ... -
POSU: A pilot study looking into the feasibility, safety and efficacy of a post-operative surgical unit for high-risk patients
(Sage, 2019-12)In this ambitious quality improvement project, we investigated the possibility of using operating theatre post-operative recovery ward to care for high-risk patients overnight. -
Bigmelon: Tools for Analysing Large DNA Methylation Datasets
(Oxford Academic, 2019-03)The datasets generated by DNA methylation analyses are getting bigger. With the release of the HumanMethylationEPIC micro-array and datasets containing thousands of samples, analyses of these large datasets using R are ... -
Intraoperative Optimization of Both Depth of Anesthesia and Cerebral Oxygenation in Elderly Patients Undergoing Coronary Artery Bypass Graft Surgery-A Randomized Controlled Pilot Trial
(Elsevier, 2020-05)Does intraoperative optimization of both depth of anesthesia and regional cerebral tissue oxygenation (rScO2) in elderly patients reduce postoperative cognitive decline (primary outcome) or delirium (secondary outcome)? -
Revisiting Criteria for Psychosis in Alzheimer’s Disease and Related Dementias: Toward Better Phenotypic Classification and Biomarker Research
(IOS Press, 2020-02)Psychotic symptoms are common in Alzheimer's disease (AD) and related neurodegenerative disorders and are associated with more rapid disease progression and increased mortality. It is unclear to what degree existing criteria ... -
Persistent C-peptide secretion in Type 1 diabetes and its relationship to the genetic architecture of diabetes
(Biomed Central, 2019-08)The objective of this cross-sectional study was to explore the relationship of detectable C-peptide secretion in type 1 diabetes to clinical features and to the genetic architecture of diabetes. -
Upregulation of HLA Class I and Antiviral Tissue Responses in Hashimoto's Thyroiditis
(Mary Ann Liebert, 2020-03)Hashimoto's thyroiditis (HT) is a common autoimmune disease of unknown origin. However, viral infections have been implicated as triggers for autoimmunity. Human leukocyte antigen (HLA) class I presents antigens to circulating ... -
De Novo Mutations in EIF2B1 Affecting eIF2 Signaling Cause Neonatal/Early-Onset Diabetes and Transient Hepatic Dysfunction
(American Diabetes Association, 2020-03)Permanent neonatal diabetes mellitus (PNDM) is caused by reduced β-cell number or impaired β-cell function. Understanding of the genetic basis of this disorder highlights fundamental β-cell mechanisms. We performed trio ... -
Genomic variant sharing: a position statement
(Wellcome, 2019-02)Sharing de-identified genetic variant data via custom-built online repositories is essential for the practice of genomic medicine and is demonstrably beneficial to patients. Robust genetic diagnoses that inform medical ... -
Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging
(CSHL Press, 2019-07)Germline mutations in fundamental epigenetic regulatory molecules including DNA methyltransferase 3 alpha (DNMT3A) are commonly associated with growth disorders, whereas somatic mutations are often associated with malignancy. ... -
Patterns of postmeal insulin secretion in individuals with sulfonylurea- treated KCNJ11 neonatal diabetes show predominance of non- KATP- channel pathways
(BMJ, 2019-12)Insulin secretion in sulfonylurea-treated KCNJ11 permanent neonatal diabetes mellitus (PNDM) is thought to be mediated predominantly through amplifying non-KATP-channel pathways such as incretins. Affected individuals ... -
Multiple injections for low back pain: what's the future?
(Springer, 2020-03)Aims: To examine the strength of evidence available for multiple facet joint injections (FJIs) and medial branch blocks (MBBs), and to report on the variations in the NHS England framework using the getting it right first ... -
Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants
(Oxford Academic, 2019-02)Iron is essential for life but contributes to oxidative damage. In Northern-European ancestry populations, HFE gene C282Y mutations are relatively common (0.3%-0.6% rare homozygote prevalence) and associated with excessive ...
RSS 1.0