• Republished: Immune checkpoint inhibitor induced large vessel vasculitis 

  Sankey, Peter (HighWire, 2021-02)

• Urinary nitrate concentration as a marker for kidney transplant rejection 

  Kirkwood, John; Smallwood, Miranda; Winyard, Paul G.; Knight, Beatrice; Shore, Angela; Gilchrist, Mark (BioMed Central, 2020-10-20)

  Background: Early identification and treatment of kidney transplant rejection episodes is vital to limit loss of function and prolong the life of the transplanted kidney and recipient. Current practice depends on detecting ...

• EuGMS 2019 Congress report: evidence-based medicine in geriatrics 

  Hope, Suzy (PubMed Central, 2020-12)

  The 2019 EuGMS Congress "Evidence-Based Medicine in Geriatrics" was held in Krakow, Poland, and attended by over 1600 participants from 64 different countries. A summary and reflection on the congress was presented in the ...

• Understanding surgical antimicrobial prescribing behaviour in the hospital setting: a systematic review and meta-ethnography protocol 

  Parker, Hazel; Britten, Nicky; Mattick, K. (BioMed Central, 2020-10-10)

  Background: Surgical specialities use extensive amounts of antimicrobials, and misuse has been widely reported, making them a key target for antimicrobial stewardship initiatives. Interventions informed by, and tailored ...

• Validation of subscales of the Severe Asthma Questionnaire (SAQ) using exploratory factor analysis (EFA) 

  Masoli, Matthew (BioMed Central, 2020-10-09)

  Background: The Severe Asthma Questionnaire (SAQ) is a health related quality of life (HRQoL) questionnaire validated for use in severe asthma. It is scored using the mean value of 16 items (SAQ score) in addition to a ...

• Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults 

  Hannon, Eilis; Mill, Jonathan (Elsevier Science, 2019-10-15)

  Background: Previous studies have reported associations between attention-deficit/hyperactivity disorder symptoms and DNA methylation in children. We report the first epigenome-wide association study meta-analysis of adult ...

• Interventions to improve the mental health of children and young people with long-term physical conditions: linked evidence syntheses 

  Moore, D. A.; Nunns, M.; Rogers, M.; Ford, T.; Garside, R.; Ukoumunne, O. C.; Anderson, R.; Dickens, C.; Logan, Stuart; Thompson Coon, J. (NIHR Journals Library, 2019-05)

  Background: Although mental health difficulties can severely complicate the lives of children and young people (CYP) with long-term physical conditions (LTCs), there is a lack of evidence about the effectiveness of ...

• Drug repositioning and repurposing for Alzheimer disease 

  Ballard, Clive; Corbett, Anne (Nature Publishing Group, 2020-12)

  Drug repositioning and repurposing can enhance traditional drug development efforts and could accelerate the identification of new treatments for individuals with Alzheimer disease (AD) dementia and mild cognitive impairment. ...

• Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity 

  Wood, Andrew R; Jones, A. G.; Frayling, Timothy M. (Silverchair Information Systems, 2021-01-01)

  Context: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, ...

• Potentially inappropriate prescribing in dementia, multi-morbidity and incidence of adverse health outcomes 

  Ballard, Clive; Melzer, David; Jones, Lindsay; Delgado, J. (Oxford University Press, 2021-02-26)

  Importance: treatment of dementia in individuals with comorbidities is complex, leading to potentially inappropriate prescribing (PIP). The impact of PIP in this population is unknown. Objective: to estimate the rate ...

• International relevance of two measures of awareness of age-related change (AARC) 

  Ballard, Clive; Ukoumunne, O. C.; Corbett, Anne (BioMed Central, 2020-09-21)

  Background: A questionnaire assessing awareness of positive and negative age-related changes (AARC gains and losses) was developed in the US and Germany. We validated the short form of the measure (AARC-10 SF) and the ...

• The Incidence of Recorded Delirium Episodes Before and After Dementia Diagnosis: Differences Between Dementia With Lewy Bodies and Alzheimer's Disease 

  Ballard, Clive (Elsevier Science, 2019-05)

  Objectives: To describe the incidence of delirium recording before and after a diagnosis of dementia is established in patients with dementia with Lewy bodies (DLB) and compare findings to a matched cohort of patients with ...

• Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants 

  Pilling, L. C.; Melzer, David (Wiley, 2019-12)

  Inherited genetic variation influencing leukocyte telomere length provides a natural experiment for testing associations with health outcomes, more robust to confounding and reverse causation than observational studies. ...

• Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis 

  Smith, Adam R.; Lunnon, Katie (BioMed Central, 2020-09-11)

  Background: Mitochondrial dysregulation and aberrant epigenetic mechanisms have been frequently reported in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and several researchers suggested that ...

• Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia 

  Mill, Jonathan (HighWire, 2020-07-31)

  Altered olfactory function is a common symptom of COVID-19, but its etiology is unknown. A key question is whether SARS-CoV-2 (CoV-2) - the causal agent in COVID-19 - affects olfaction directly, by infecting olfactory ...

• The impact of the World Health Organization Health Promoting Schools framework approach on diet and physical activity behaviours of adolescents in secondary schools: a systematic review 

  McHugh, C.; Hurst, A.; Bethel, A.; Lloyd, J.; Logan, S.; Wyatt, K. (Elsevier Science, 2020-05)

  Objective: To examine the effectiveness of interventions using the World Health Organization Health Promoting Schools (HPSs) framework approach in increasing physical activity (PA) and improving the diet of 11-18-year-ol ...

• Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement 

  Hannon, Eilis; Mill, Jonathan (Elsevier Science, 2020-05-08)

  DNA methylation plays an important role in both normal human development and risk of disease. The most utilized method of assessing DNA methylation uses BeadChips, generating an epigenome-wide "snapshot" of >450,000 ...

• Increased Induction Infliximab Clearance Predicts Early Antidrug Antibody Detection 

  Ahmad, Tariq (Wiley, 2021-02)

  Treatment of patients with biologics such as infliximab may trigger development of antidrug antibodies, which are associated with faster drug clearance, reduced treatment efficacy, and increased risk of infusion-related ...

• Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity 

  Yaghootkar, Hanieh; Frayling, Timothy M. (HighWire, 2020-12)

  Leptin influences food intake by informing the brain about the status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated by administering ...

• Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt-Jakob disease 

  Smith, Adam R.; Smith, R. G.; Lunnon, Katie (Springer, 2020-12)

  Prion diseases are fatal and transmissible neurodegenerative disorders caused by the misfolding and aggregation of prion protein. Although recent studies have implicated epigenetic variation in common neurodegenerative ...

View more