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The design and development of a complex multifactorial falls assessment intervention for falls prevention: The Prevention of Falls Injury Trial (PreFIT).
(BioMed Central, 2017-06-01)This paper describes the design and development of a complex multifactorial falls prevention (MFFP) intervention for implementation and testing within the framework of a large UK-based falls prevention randomised controlled ... -
Socioeconomic disparities in first stroke incidence, quality of care, and survival: a nationwide registry-based cohort study of 44 million adults in England.
(Elsevier, 2018-04)We aimed to estimate socioeconomic disparities in the incidence of hospitalisation for first-ever stroke, quality of care, and post-stroke survival for the adult population of England. -
Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardias (REVERT): a randomised controlled trial
(Elsevier, 2015-10-31)BACKGROUND: The Valsalva manoeuvre is an internationally recommended treatment for supraventricular tachycardia, but cardioversion is rare in practice (5-20%), necessitating the use of other treatments including adenosine, ... -
Discovery of a novel dominant mutation in the REN gene after forty years of renal disease: a case report.
(BioMed Central, 2017-07-12)Heterozygous mutations in the gene encoding renin (REN) cause autosomal dominant tubulointerstitial kidney disease (ADTKD), early-onset anaemia and hyperuricaemia; only four different mutations have been described in the ... -
Assessing the effectiveness of Enhanced Psychological Care for patients with depressive symptoms attending cardiac rehabilitation compared with treatment as usual (CADENCE): a pilot cluster randomised controlled trial.
(BioMed Central, 2018-04-02)Around 17% of people attending UK cardiac rehabilitation programmes have depression. Optimising psychological wellbeing is a rehabilitation goal, but provision of psychological care is limited. We developed and piloted an ... -
End-Stage Renal Disease (ESRD): Physical Activity and Elucidation of Its Effects on Biochemical and Haematological Parameters in Haemodialysis Patients
(iMedPub, 2016-08-02)End-stage renal disease (ESRD) is a progressive disorder for which there is no prospect of recovery, and for which patients receive regular haemodialysis. In ESRD the ability of the kidneys to excrete metabolic waste ... -
Physical activity, sleep, and fatigue in community dwelling Stroke Survivors.
(Nature, 2018-05-21)Stroke can lead to physiological and psychological impairments and impact individuals' physical activity (PA), fatigue and sleep patterns. We analysed wrist-worn accelerometry data and the Fatigue Assessment Scale from 41 ... -
Diabetes, cardiovascular disease and the microcirculation.
(BioMed Central, 2018-04-18)Cardiovascular disease (CVD) is the leading cause of mortality in people with type 2 diabetes mellitus (T2DM), yet a significant proportion of the disease burden cannot be accounted for by conventional cardiovascular risk ... -
Outcomes of Treated Hypertension at Age 80 and Older: Cohort Analysis of 79,376 Individuals.
(Wiley, 2016-12-30)To estimate outcomes according to attained blood pressure (BP) in the oldest adults treated for hypertension in routine family practice.