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Raman spectroscopy and multivariate analysis for the non invasive diagnosis of clinically inconclusive vulval lichen sclerosus.
(Royal Society of Chemistry, 2016-11-09)Vulval lichen sclerosus (LS) is a common inflammatory condition associated with an increased risk of developing vulval carcinoma. Diagnosis is usually clinical although biopsy is necessary if the diagnosis is uncertain or ... -
Echogenicity of the Common Carotid Artery Intima-Media Complex in Stroke.
(Elsevier, 2016-03-01)The grey-scale median of the common carotid artery intima-media complex (IM-GSM) characterizes arterial wall composition, and a low IM-GSM is associated with increased cardiovascular mortality in the elderly. We aimed to ... -
GLP-1 analogue-induced weight loss does not improve obesity-induced AT dysfunction
(Portland Press, 2017-01-03)Glucagon-like peptide-1 (GLP-1) analogues aid weight loss which improves obesity-associated adipose tissue (AT) dysfunction. GLP-1 treatment may however also directly influence AT which expresses GLP-1 receptors. This study ... -
Red Blood Cell Susceptibility to Pneumolysin: Correlation with Membrane Biochemical and Physical Properties.
(Journal of Biological Chemistry, 2016-03-16)This study investigated the effect of the biochemical and biophysical properties of the plasma membrane as well as membrane morphology on the susceptibility of human red blood cells to the cholesterol-dependent cytolysin ... -
Prevalence of systolic inter-arm differences in blood pressure for different primary care populations: systematic review and meta-analysis.
(Royal College of General Practitioners, 2016-11)Various prevalence figures have been reported for inter-arm differences in blood pressure (IAD); variation may be explained by differing population vascular risk and by measurement method. -
Adipose tissue is influenced by hypoxia of obstructive sleep apnea syndrome independent of obesity.
(Elsevier Masson, 2017-01-25)Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular risk and diabetes independent of obesity. We investigated whether adipose tissue dysfunction is exacerbated due to increased tissue hypoxia. -
Relationship Between Urinary Nitrate Excretion and Blood Pressure in the InChianti Cohort.
(Oxford Academic, 2017-07-01)Inorganic nitrate from the oxidation of endogenously synthesized nitric oxide (NO) or consumed in the diet can be reduced to NO via a complex enterosalivary circulation pathway. The relationship between total nitrate ... -
Rapid infrared mapping for highly accurate automated histology in Barrett's oesophagus.
(Royal Society of Chemistry, 2016-10-07)Barrett's oesophagus (BE) is a premalignant condition that can progress to oesophageal adenocarcinoma. Endoscopic surveillance aims to identify potential progression at an early, treatable stage, but generates large numbers ... -
Identification of cancer associated molecular changes in histologically benign vulval disease found in association with vulval squamous cell carcinoma using Fourier transform infrared spectroscopy
(Royal Society of Chemistry, 2016)This study evaluates the capability of Fourier transform infrared spectroscopy (FTIR-S) in the differentiation of molecular changes in vulval intraepithelial neoplasia (VIN) and lichen sclerosus (LS) found in association ... -
Associations between interarm differences in blood pressure and cardiovascular disease outcomes: protocol for an individual patient data meta-analysis and development of a prognostic algorithm.
(BMJ, 2017-07-02)Individual cohort studies in various populations and study-level meta-analyses have shown interarm differences (IAD) in blood pressure to be associated with increased cardiovascular and all-cause mortality. However, key ...