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Adherence to Oral Glucose-Lowering Therapies and Associations With 1-Year HbA1c: A Retrospective Cohort Analysis in a Large Primary Care Database.
(American Diabetes Association, 2016-02)The impact of taking oral glucose-lowering medicines intermittently, rather than as recommended, is unclear. We conducted a retrospective cohort study using community-acquired U.K. clinical data (Clinical Practice Research ... -
Maternal hypothyroxinaemia in pregnancy is associated with obesity and adverse maternal metabolic parameters.
(BioScientifica, 2016-01)Subclinical hypothyroidism and isolated hypothyroxinaemia in pregnancy have been associated with an increased risk of gestational diabetes. We aimed to ascertain if these women have a worse metabolic phenotype than euthyroid ... -
Time to change the HbA1c cut-off for prediabetes
(Wiley, 2016-03-01) -
Should Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c?
(PLoS One, 2016-04-06)Baseline HbA1c is a major predictor of response to glucose lowering therapy and therefore a potential confounder in studies aiming to identify other predictors. However, baseline adjustment may introduce error if the ... -
Maternal thyroid function in pregnant women with a breech presentation in late gestation.
(Wiley, 2016-02-15)Breech presentation occurs in 3-5% of all full-term pregnancies, and is associated with obstetric complications. The known risk factors for breech presentation include prematurity, low birth-weight, multiple pregnancy, ... -
Practical Classification Guidelines for Diabetes in patients treated with insulin: a cross-sectional study of the accuracy of diabetes diagnosis.
(Royal College of General Practitioners, 2016-04-14)Differentiating between type 1 and type 2 diabetes is fundamental to ensuring appropriate management of patients, but can be challenging, especially when treating with insulin. The 2010 UK Practical Classification Guidelines ... -
Random non-fasting C-peptide: bringing robust assessment of endogenous insulin secretion to the clinic.
(Wiley, 2016-04-21)Measuring endogenous insulin secretion using C-peptide can assist diabetes management, but standard stimulation tests are impractical for clinical use. Random non-fasting C-peptide assessment would allow testing when a ... -
Urine C-peptide creatinine ratio can be used to assess insulin resistance and insulin production in people without diabetes: an observational study.
(BMJ, 2013-12-18)The current assessment of insulin resistance (IR) in epidemiology studies relies on the blood measurement of C-peptide or insulin. A urine C-peptide creatinine ratio (UCPCR) can be posted from home unaided. It is validated ... -
Five-year follow-up for women with subclinical hypothyroidism in pregnancy.
(Endocrine Society, 2013-11-11)Increasing numbers of women are being treated with l-thyroxine in pregnancy for mild thyroid dysfunction because of its association with impaired neuropsychological development in their offspring and other adverse obstetric ...