Browsing Medical Services by Issue Date
Now showing items 21-40 of 1091
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Offspring birthweight is not associated with paternal insulin resistance
(Springer, 2006-09-06)AIMS/HYPOTHESIS: Low birthweight is associated with insulin resistance and other insulin resistance-related phenotypes: diabetes, hypertension, and vascular disease in later life. The underlying mechanism is unclear. The ... -
The impact of maternal glycemia and obesity on early postnatal growth in a nondiabetic Caucasian population
(American Diabetes Association, 2007-01-24)OBJECTIVE: Offspring of mothers with diabetes have increased birth weight and higher rates of obesity in early childhood. The relative role of maternal glycemia and maternal obesity is uncertain. We therefore studied the ... -
The interarm blood pressure difference as predictor of cardiovascular events in patients with hypertension in primary care: cohort study
(Nature, 2007-04-26)Objectives of this study were to measure the prevalence of a difference in blood pressure (BP) between arms and determine whether a difference is associated with increased risk of cardiovascular events or death. A prospective ... -
Measurement of cord insulin and insulin-related peptides suggests that girls are more insulin resistant than boys at birth
(American Diabetes Association, 2007-05-02)OBJECTIVE: We aimed to examine sex differences in insulin and insulin propeptide concentrations at birth using validated cord blood collection. RESEARCH DESIGN AND METHODS: We tested the impact on insulin and insulin ... -
Fungal septicaemia in patients with cystic fibrosis associated with totally implantable venous access device system.
(Elsevier, 2007-09)Fungal septicaemia is a serious and potentially fatal condition. We report 4 cases in patients with Cystic Fibrosis (CF) associated with totally implantable venous access device system (TIVADS). -
Partial and whole gene deletion mutations of the GCK and HNF1A genes in maturity-onset diabetes of the young.
(Springer, 2007-11)Heterozygous mutations of glucokinase (GCK) and hepatocyte nuclear factor-1 alpha (HNF1A; also known as hepatic transcription factor 1 [TCF1]) genes are the most common cause of MODY. Genomic deletions of the HNF1B (also ... -
The impact of thyroid eye disease upon patients' wellbeing: a qualitative analysis.
(Wiley, 2008-04)Previous studies using quality of life (QoL) questionnaires have shown poor QoL in patients with thyroid eye disease (TED). However, predetermined questionnaires limit in-depth investigation of psychosocial and emotional ... -
Road traffic accidents and diabetes: insulin use does not determine risk
(Wiley, 2008-05-01)AIMS: Progressive restrictions placed on insulin-treated patients with diabetes exclude them from driving group 2 and class C1 and D1 vehicles. This reflects an assumption that an increased risk of hypoglycaemia in these ... -
Elbow extension test to rule out elbow fracture: multicentre, prospective validation and observational study of diagnostic accuracy in adults and children
(BMJ, 2008-12-09)OBJECTIVE: To determine whether full elbow extension as assessed by the elbow extension test can be used in routine clinical practice to rule out bony injury in patients presenting with elbow injury. DESIGN: Adults: ... -
Pregnancy outcome in patients with raised blood glucose due to a heterozygous glucokinase gene mutation.
(Wiley, 2009-01)To assess determinants of fetal growth in the offspring of pregnant women with hyperglycaemia due to a heterozygous glucokinase (GCK) gene mutation. -
A genetic diagnosis of HNF1A diabetes alters treatment and improves glycaemic control in the majority of insulin-treated patients.
(Wiley, 2009-04)Hepatocyte nuclear factor-1 alpha (HNF1A) gene mutations are the commonest cause of monogenic diabetes, but patients are often misdiagnosed as having Type 1 diabetes and started on insulin treatment. Patients with HNF1A ... -
The patient experience of services for thyroid eye disease in the United Kingdom: results of a nationwide survey.
(BioScientifica, 2009-09)A recent consensus statement from the European Group on Graves' Orbitopathy recommends referring all patients with thyroid eye disease (TED), except the mildest cases, to a specialist multidisciplinary clinic. -
Increased all-cause and cardiovascular mortality in monogenic diabetes as a result of mutations in the HNF1A gene.
(Wiley, 2010-02)To investigate all-cause and cardiovascular mortality in subjects with diabetes caused by a mutation in the hepatocyte nuclear factor 1alpha gene (HNF1A). -
Stopping insulin injections following genetic testing in diabetes: impact on identity.
(Wiley, 2010-07)Identification of genes causing monogenic diabetes has led to treatment change, from insulin to sulphonylureas for many previously considered insulin dependent. Changing treatment has led to improved glycaemic control and ... -
Maturity-onset diabetes of the young (MODY): how many cases are we missing?
(Springer, 2010-12)Maturity-onset diabetes of the young is frequently misdiagnosed as type 1 or type 2 diabetes. A correct diagnosis of MODY is important for determining treatment, but can only be confirmed by molecular genetic testing. We ... -
Urine C-peptide creatinine ratio is a noninvasive alternative to the mixed-meal tolerance test in children and adults with type 1 diabetes.
(Highwire, 2011-03)Stimulated serum C-peptide (sCP) during a mixed-meal tolerance test (MMTT) is the gold standard measure of endogenous insulin secretion, but practical issues limit its use. We assessed urine C-peptide creatinine ratio ... -
Quality of life in thyroid eye disease: impact of quality of care.
(BioScientifica, 2011-05)Thyroid eye disease (TED) is a chronic debilitating condition causing physical discomfort, facial disfigurement and impaired visual function. The physical consequences of TED could have a negative and lasting impact on ... -
High-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes.
(Highwire, 2011-08)Maturity-onset diabetes of the young (MODY) as a result of mutations in hepatocyte nuclear factor 1-α (HNF1A) is often misdiagnosed as type 1 diabetes or type 2 diabetes. Recent work has shown that high-sensitivity C-reactive ... -
Urine C-peptide creatinine ratio is an alternative to stimulated serum C-peptide measurement in late-onset, insulin-treated diabetes.
(Wiley, 2011-09)Serum C-peptide measurement can assist clinical management of diabetes, but practicalities of collection limit widespread use. Urine C-peptide creatinine ratio may be a non-invasive practical alternative. The stability of ...