• Hyperinsulinaemic hypoglycaemia: A new presentation of 16p11.2 deletion syndrome 

  Flanagan, Sarah (Wiley, 2019-05)

• Assessing effector T cells in type 1 diabetes 

  Eichmann, M. (Wolters Kluwer Health, Inc., 2020-08)

  Purpose of review: The role of T cells specific for islet autoantigens is proven in pathogenesis of type 1 diabetes. Recently, there has been rapid expansion in the number of T-cell subsets identified, this has coincided ...

• Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes 

  Carr, A. L. J.; Flaxman, Christine; Sharp, S. A.; Jones, A. G.; Richardson, S. J.; Shields, Beverley M.; Oram, Richard A. (Wiley, 2020-07-07)

  Aims: Misclassification of diabetes is common due to an overlap in the clinical features of type 1 and type 2 diabetes. Combined diagnostic models incorporating clinical and biomarker information have recently been developed ...

• Prognostic imaging biomarkers for diabetic kidney disease (iBEAt): study protocol 

  Gooding, Kim M.; Ball, Claire; Gilchrist, Mark; Shore, Angela (BioMed Central, 2020-06-29)

  Background: Diabetic kidney disease (DKD) remains one of the leading causes of premature death in diabetes. DKD is classified on albuminuria and reduced kidney function (estimated glomerular filtration rate (eGFR)) but ...

• Predicting post one-year durability of glucose-lowering monotherapies in patients with newly-diagnosed type 2 diabetes mellitus - A MASTERMIND precision medicine approach (UKPDS 87) 

  Hattersley, Andrew T.; Jones, Angus G.; Shields, Beverley M. (Elsevier Science, 2020-08)

  Aims: Predicting likely durability of glucose-lowering therapies for people with type 2 diabetes (T2D) could help inform individualised therapeutic choices. Methods: We used data from UKPDS patients with newly-diagnosed ...

• A Novel HNF4A Mutation Causing Three Phenotypic Forms of Glucose Dysregulation in a Family 

  Flanagan, Sarah (Frontiers Media SA, 2020-06-26)

  Maturity-onset diabetes of the young (MODY) classically describes dominantly inherited forms of monogenic diabetes diagnosed before 25 years of age due to pancreatic β-cell dysfunction. In contrast, mutations in certain ...

• Improving understanding of type 2 diabetes remission: research recommendations from Diabetes UK's 2019 remission workshop 

  Andrews, Rob (Wiley, 2020-11)

  Aim: To describe the process and outputs of a workshop convened to identify key priorities for future research in the area of remission of type 2 diabetes, and provide recommendations to researchers and research funders ...

• Colles' type distal radial fractures undergoing manipulation in the ED: a multicentre observational cohort study 

  Malik, Hamza; Appelboam, Andrew (HighWire, 2020-08)

  Background: Colles' type fractures of the distal radius are one of the most commonly manipulated fractures in the ED. Local audit data suggest that a high proportion of these injuries undergo subsequent surgical fixation. ...

• A Global, Prospective, Observational Study Measuring Disease Burden and Suffering in Patients with Ulcerative Colitis Using the Pictorial Representation of Illness and Self-Measure Tool 

  Ahmad, Tariq (Silverchair Information Systems, 2020-07-29)

  Background: The understanding the Impact of ulcerative COlitis aNd Its assoCiated disease burden on patients study [ICONIC] was a 2-year, global, prospective, observational study evaluating the cumulative burden of ulcerative ...

• Parental experiences of a diagnosis of neonatal diabetes and perceptions of newborn screening for glucose: a qualitative study 

  Shepherd, Maggie; Knight, Bridget A.; Laskey, Katherine; McDonald, Timothy J. (HighWire, 2020-11-04)

  Neonatal diabetes presents <6 months of life but delays in recognition result in presentation with life-threatening hyperglycaemia/diabetic ketoacidosis. Early identification and rapid genetic diagnosis is crucial and ...

• Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) 

  Hattersley, Andrew T. (Springer, 2020-09)

  The convergence of advances in medical science, human biology, data science and technology has enabled the generation of new insights into the phenotype known as 'diabetes'. Increased knowledge of this condition has emerged ...

• Precision Medicine in Diabetes: A Consensus Report From the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) 

  Hattersley, Andrew T. (HighWire, 2020-07)

  The convergence of advances in medical science, human biology, data science, and technology has enabled the generation of new insights into the phenotype known as "diabetes." Increased knowledge of this condition has emerged ...

• Evaluation of pre-hospital use of a valsalva assist device in the emergency treatment of supraventricular tachycardia [EVADE]: a randomised controlled feasibility trial 

  Appelboam, Andrew; Ewings, P. (BioMed Central, 2020-05-25)

  Background: The valsalva manoeuvre is an internationally recommended initial treatment for supraventricular tachycardia (SVT). The pre-hospital use of a valsalva assist device, to help deliver this manoeuvre, could improve ...

• Variations in diabetes transition care for children and young people: a national survey 

  Moudiotis, Christopher (Wiley, 2020-08)

• Treatment Combinations for Alzheimer's Disease: Current and Future Pharmacotherapy Options 

  Ballard, Clive (IOS Press, 2019)

  Although Alzheimer's disease (AD) is the world's leading cause of dementia and the population of patients with AD continues to grow, no new therapies have been approved in more than a decade. Many clinical trials of ...

• Hereditary spastic paraplegia: from diagnosis to emerging therapeutic approaches 

  Crosby, Andrew H. (Elsevier Science, 2019-12)

  Hereditary spastic paraplegia (HSP) describes a heterogeneous group of genetic neurodegenerative diseases characterised by progressive spasticity of the lower limbs. The pathogenic mechanism, associated clinical features, ...

• Differential effects of saturated and unsaturated fatty acids on autophagy in pancreatic β-cells 

  Dhayal, S.; Welters, Hannah J.; Morgan, Noel G. (Sheridan PubFactory, 2019-11)

  Long-chain saturated fatty acids are lipotoxic to pancreatic β-cells, whereas most unsaturates are better tolerated and some may even be cytoprotective. Fatty acids alter autophagy in β-cells and there is increasing evidence ...

• What the HLA-I!-Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes 

  Wyatt, R. C.; Richardson, S. J. (Springer, 2019-12-09)

  Purpose of review: Hyperexpression of classical HLA class I (HLA-I) molecules in insulin-containing islets has become a widely accepted hallmark of type 1 diabetes pathology. In comparison, relatively little is known about ...

• Type 1 diabetes genetic risk score is discriminative of diabetes in non-Europeans: evidence from a study in India 

  Sharp, S. A.; Patel, Kashyap; Weedon, M. N.; Oram, Richard A. (Nature Publishing Group, 2020-06-11)

  Type 1 diabetes (T1D) is a significant problem in Indians and misclassification of T1D and type 2 diabetes (T2D) is a particular problem in young adults in this population due to the high prevalence of early onset T2D at ...

• Quality improvement project identifies factors associated with delay in IBD diagnosis 

  Walker, Gareth; Lin, Simeng; Chanchlani, Neil; Thomas, Amanda; Hendy, Peter; Heerasing, Neel; Moore, Lucy; Chee, Desmond; Bewshea, Claire; Mays, Joseph; Kennedy, Nicholas A.; Ahmad, Tariq; Goodhand, James R. (Wiley, 2020-08)

  Background: Delay in the diagnosis of inflammatory bowel disease (IBD) is common and contemporary UK studies are lacking. Aim: To determine factors associated with, and the consequences of, a prolonged time to diagnosis ...

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