Medical Services
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This community includes the research outputs from the Medical Services division which includes services such as: Cardiology, Diabetes, the Emergency Department, Neurology and Stroke. Browse the list of individual departments below.
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A prospective observational study of iron isomaltoside in haemodialysis patients with chronic kidney disease treated for iron deficiency (DINO).
(BioMed Central, 2019-01-10)Iron deficiency is frequent in haemodialysis (HD) patients with chronic kidney disease (CKD), and intravenous iron is an established therapy for these patients. This study assessed treatment routine, effectiveness, and ... -
GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation
(Cell Press, 2019-01-08)Heterozygous de novo mutations in GATA6 are the most frequent cause of pancreatic agenesis in humans. In mice, however, a similar phenotype requires the biallelic loss of Gata6 and its paralog Gata4. To elaborate the ... -
The feasibility of online video calling to engage patients with cystic fibrosis in exercise training
(Sage, 2019)Physical activity (PA), including structured exercise is an essential component in the management of cystic fibrosis (CF). The use of telehealth such as video-calling may be a useful method for the delivery of exercise and ... -
Home visits: A new screening tool for frailty? A retrospective exploratory study.
(Academy of Family Physicians India, 2018-09)In the United Kingdom, the new NHS contract for primary care mandates that practices use the Electronic Frailty Index (EFI) to screen for frailty and apply clinical judgment, based on knowledge of the patient, to decide ... -
Future Roadmaps for Precision Medicine Applied to Diabetes: Rising to the Challenge of Heterogeneity.
(Hindawi, 2018-11)Precision medicine, the concept that specific treatments can be targeted to groups of individuals with specific genetic, cellular, or molecular features, is a key aspect of modern healthcare, and its use is rapidly expanding. ... -
COPD Biomarkers and their Interpretation.
(American Thoracic Society, 2018-12-28)The pathology and impact of COPD results from an abnormal inflammatory process resulting in tissue damage with ineffective repair in response to toxic inhalants (especially cigarette smoke). Identification of mechanisms ... -
Response to Prakash et al.
(Nature, 2018-12-21) -
Kufs disease due to mutation of CLN6: clinical, pathological and molecular genetic features.
(Oxford Journals, 2018-12-15)Kufs disease is the major adult form of neuronal ceroid lipofuscinosis, but is rare and difficult to diagnose. Diagnosis was traditionally dependent on the demonstration of characteristic storage material, but distinction ... -
Renal artery sympathetic denervation: Back on track!
(Oxford Academic, 2018-12-07) -
Testing of a novel Valsalva Assist Device with supine and modified positions in healthy volunteers.
(BMJ, 2018-12-01)The Valsalva manoeuvre (VM) is used to treat supraventricular tachycardia (SVT) by inducing a vagal response (drop in HR). There is debate as to the best position in which to carry out the VM and how the strain should be ... -
Current Controversies in Chronic Obstructive Pulmonary Disease: A Report from the GOLD Scientific Committee.
(American Thoracic Society, 2018-11-14) -
Procedural sedation of elderly patients by emergency physicians: a safety analysis of 740 patients
(Elsevier, 2018-12)The elderly are perceived as a high-risk group for procedural sedation. Concern exists regarding the safety of sedation of this patient group by emergency physicians, particularly when using propofol.We analysed prospectively ... -
Increased Mortality and Morbidity in Patients with Chronic Hypoparathyroidism: A population based study.
(Wiley, 2018-10-30)A population based study was undertaken to determine the mortality and morbidity for people with hypoparathyroidism compared to the general population. -
Utility of systematic TSHR gene testing in adults with hyperthyroidism lacking overt autoimmunity and diffuse uptake on thyroid scintigraphy.
(Wiley, 2018-10-29)Patients with hyperthyroidism lacking autoimmune features but showing diffuse uptake on thyroid scintigram can have either Graves' disease or germline activating TSHR mutation. It is important to identify patients with ... -
Genome-Wide and Abdominal MRI-Imaging Data Provides Evidence that a Genetically Determined Favourable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease and Hypertension.
(American Diabetes Association, 2018-10-23)Recent genetic studies have identified alleles associated with opposite effects on adiposity and risk of type 2 diabetes. We aimed to identify more of these variants and test the hypothesis that such "favourable adiposity" ... -
A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy.
(American Diabetes Association, 2018-10-23)Progression to insulin therapy in clinically diagnosed type 2 diabetes is highly variable. GAD65 autoantibodies (GADA) are associated with faster progression, but their predictive value is limited. We aimed to determine ... -
De Novo Pathogenic Variants in CACNA1E Cause Developmental and Epileptic Encephalopathy with Contractures, Macrocephaly, and Dyskinesias
(Cell Press, 2018-11)Developmental and epileptic encephalopathies (DEEs) are severe neurodevelopmental disorders often beginning in infancy or early childhood that are characterized by intractable seizures, abundant epileptiform activity on ... -
Wide variation in the use and understanding of therapeutic drug monitoring for anti-TNF agents in inflammatory bowel disease: an inexact science?
(Taylor & Francis, 2018-10-24)We aimed to understand the way in which therapeutic drug monitoring (TDM) is used, understood and interpreted for anti-TNF agents in IBD.
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