• Global Initiative for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease. The 2020 GOLD Science Committee Report on COVID-19 and Chronic Obstructive Pulmonary Disease 

  Halpin, David M (Atypon, 2021-01-01)

  The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has raised many questions about the management of patients with chronic obstructive pulmonary disease (COPD) and whether modifications of their ...

• Along came a spider: an unusual organism identified in a peritoneal dialysis patient, a case report and literature review 

  Carnall, Victoria Jane; Auckland, Cressida; Mulgrew, Christopher J. (Bio Med Central, 2020-11-11)

  Background: Peritoneal dialysis-associated peritonitis can uncommonly be caused by fungal infections. When they do present, they are associated with significant mortality and morbidity. We describe a case where a sample ...

• Diagnosis and management of mild to moderate psoriasis 

  Frow, Helen (Wiley, 2020-09-04)

  Psoriasis is a common long-term inflammatory skin condition, which when mild or moderate in severity can be managed effectively with topical treatments and lifestyle advice. This article focuses on the management of mild ...

• Long-term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients With Sulfonylurea-Treated ABCC8 Permanent Neonatal Diabetes 

  Bowman, Pamela; Shepherd, Maggie; Babiker, Tarig; Thomas, N. J.; De Franco, Elisa; Ellard, Sian; Flanagan, Sarah; Hattersley, Andrew T. (HighWire, 2021-01)

  Objective: ABCC8 mutations cause neonatal diabetes mellitus that can be transient (TNDM) or, less commonly, permanent (PNDM); ∼90% of individuals can be treated with oral sulfonylureas instead of insulin. Previous studies ...

• Root-cause analyses of missed opportunities for the diagnosis of colorectal cancer in patients with inflammatory bowel disease 

  Chee, Desmond; Hamilton, Benjamin; Heerasing, Neel; Hendy, Peter; Chanchlani, Neil; Lin, Simeng; Daniels, Ian R.; Silva, N.; Osborne, Melanie; Kennedy, Nicholas A.; Goodhand, James R.; Ahmad, Tariq (Wiley, 2021-01)

  Background: Colonoscopic surveillance in patients with inflammatory bowel disease (IBD) leads to earlier detection of colorectal cancer (CRC) and reduces CRC-associated mortality. However, it is limited by poor adherence ...

• Comparison of oral glucose tolerance test and ambulatory glycaemic profiles in pregnant women in Uganda with gestational diabetes using the FreeStyle Libre flash glucose monitoring system 

  Jones, A. G. (BioMed Central, 2020-10-19)

  Background: The diagnosis of hyperglycaemia in sub-Saharan Africa (SSA) is challenging. Blood glucose levels obtained during oral glucose tolerance test (OGTT) may not reflect home glycaemic profiles. We compare OGTT results ...

• Sarcopenia and Variation in the Human Leukocyte Antigen Complex 

  Jones, Garan; Pilling, L. C.; Melzer, David (Oxford University Press, 2020-01-20)

  Background: Aging is characterized by chronic inflammation plus loss of muscle mass and strength, termed sarcopenia. Human leukocyte antigen (HLA) types are drivers of autoimmune disease, although with limited penetrance. ...

• Predictors of changes after reasoning training in healthy adults 

  Ballard, Clive; Corbett, Anne (Wiley, 2020-12)

  Objectives: To investigate predictors of performance changes and their time course in healthy older adults. Design: A post hoc analysis of a RCT investigating the effect of reasoning cognitive training (ReaCT) compared ...

• Effects of Purified Anthocyanins in People at Risk for Dementia: Study Protocol for a Phase II Randomized Controlled Trial 

  Ballard, Clive (Frontiers Media SA, 2020-09-02)

  Background: The number of people with dementia is increasing, with huge challenges for society and health-care systems. There are no disease-modifying therapies available. There is, therefore, an urgent need to identify ...

• Agitation and impulsivity in mid and late life as possible risk markers for incident dementia 

  Ballard, Clive (PubMed Central, 2020-09-06)

  To identify knowledge gaps regarding new-onset agitation and impulsivity prior to onset of cognitive impairment or dementia the International Society to Advance Alzheimer's Research and Treatment Neuropsychiatric Syndromes ...

• FLAME: A computerized neuropsychological composite for trials in early dementia 

  Corbett, Anne; Creese, Byron; Ballard, Clive (PubMed Central, 2020-10-14)

  Introduction: Sensitive neuropsychological tests are needed to improve power for clinical trials in early Alzheimer's disease (AD). Methods: To develop a neuropsychological composite (FLAME - Factors of Longitudinal ...

• Type 2 Diabetes and COVID-19-Related Mortality in the Critical Care Setting: A National Cohort Study in England, March-July 2020 

  Dennis, J. M.; Thomas, N. J.; Patel, Kashyap; Hattersley, Andrew T.; McGovern, Andrew (HighWire, 2021-01)

  Objective: To describe the relationship between type 2 diabetes and all-cause mortality among adults with coronavirus disease 2019 (COVID-19) in the critical care setting. Research design and methods: This was a nationwide ...

• Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance 

  Cruz, Ana Miguel; Beall, Craig (Frontiers Media SA, 2020-09-25)

  Saturated fatty acids such as palmitate contribute to the development of Type 2 Diabetes by reducing insulin sensitivity, increasing inflammation and potentially contributing to anabolic resistance. We hypothesized that ...

• Tip of the Iceberg: Assessing the Global Socioeconomic Costs of Alzheimer's Disease and Related Dementias and Strategic Implications for Stakeholders 

  Ballard, Clive (IOS Press, 2019)

  While it is generally understood that Alzheimer's disease (AD) and related dementias (ADRD) is one of the costliest diseases to society, there is widespread concern that researchers and policymakers are not comprehensively ...

• "I'm in a very good frame of mind": a qualitative exploration of the experience of standing frame use in people with progressive multiple sclerosis 

  Jarrett, Louise (HighWire, 2020-10-28)

  Objectives: The study aim was to explore the experiences of people with progressive multiple sclerosis (MS) and their standing assistants during their participation in Standing Up in Multiple Sclerosis, a randomised ...

• The Impact of NOD2 Genetic Variants on the Gut Mycobiota in Crohn's Disease Patients in Remission and in Individuals Without Gastrointestinal Inflammation 

  Kennedy, Nicholas A. (Silverchair Information Systems, 2021-05-04)

  Background and aims: Historical and emerging data implicate fungi in Crohn's disease [CD] pathogenesis. However, a causal link between mycobiota, dysregulated immunity, and any impact of NOD2 variants remains elusive. This ...

• Editorial: is pharmacogenetic testing for adverse effects to IBD treatments ready for roll-out? 

  Chee, Desmond; Goodhand, James R.; Ahmad, Tariq (Wiley, 2020-09)

• Unmet needs, health policies, and actions during the COVID-19 pandemic: a report from six European countries 

  Hope, Suzy (PubMed Central, 2021-02)

  Purpose: The United Nations (UN) has published a Policy Brief on the impact of the Coronavirus Disease 2019 (COVID-19) that identifies policies and responses to protect older adults. Our objective was to summarize actions, ...

• Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time: An IMI-DIRECT study 

  McDonald, Timothy J.; Perry, Mandy (Wiley, 2021-02)

  Aim: To examine the hypothesis that, based on their glucose curves during a seven-point oral glucose tolerance test, people at elevated type 2 diabetes risk can be divided into subgroups with different clinical profiles ...

• Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset? 

  Richardson, S. J. (Springer, 2021-01)

  Available evidence provides arguments both for and against a primary pathogenic role for T cells in human type 1 diabetes. Genetic susceptibility linked to HLA Class II lends strong support. Histopathology documents HLA ...

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