• The challenge of diagnosing type 1 diabetes in older adults 

  Jones, A. G.; Shields, B. M.; Dennis, J. M.; Hattersley, Andrew T.; McDonald, Timothy J.; Thomas, N. J. (Wiley, 2020-02-11)

• Renal nitrate clearance in chronic kidney disease 

  Williams, Jennifer K.; Smallwood, M. J.; Benjamin, N.; D'Souza, Richard J.; Shore, Angela C; Winyard, P. G.; Gilchrist, M. (Elsevier Science, 2020-04)

  Background: Nitric oxide (NO) is rapidly oxidised in humans to nitrite and nitrate, with nitrate being present in much greater abundance. These oxidation products can be recycled back into nitric oxide via a complex ...

• Homozygous Hypomorphic HNF1A Alleles Are a Novel Cause of Young-Onset Diabetes and Result in Sulfonylurea-Sensitive Diabetes 

  Caswell, Richard; Colclough, Kevin; Ellard, Sian (American Diabetes Association, 2020-04)

  Objective: Heterozygous loss-of-function mutations in HNF1A cause maturity-onset diabetes of the young (MODY). Affected individuals can be treated with low-dose sulfonylureas. Individuals with homozygous HNF1A mutations ...

• The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study 

  Hattersley, Andrew; McDonald, Timothy J. (Springer, 2020-04)

  Aims/hypothesis: It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed twin-cycle ...

• Dominant mutations of the Notch ligand Jagged1 cause peripheral neuropathy 

  Barwick, K. E. S.; Baple, Emma L.; Crosby, Andrew H. (American Society for Clinical Investigation, 2020-03-02)

  Notch signaling is a highly conserved intercellular pathway with tightly regulated and pleiotropic roles in normal tissue development and homeostasis. Dysregulated Notch signaling has also been implicated in human disease, ...

• The systemic microcirculation in dialysis populations 

  Williams, Jennifer K.; Gilchrist, Mark; Strain, David; Shore, Angela (Wiley, 2020-02-17)

  In a rapidly expanding population of patients with chronic kidney disease, including 2 million people requiring renal replacement therapy, cardiovascular mortality is 15 times greater than the general population. In addition ...

• Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta cells 

  Walker, Jonathan Neil (Springer Nature, 2020-01-20)

  Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting alpha, insulin-producing beta and somatostatin-releasing delta cells1. Somatostatin is a powerful paracrine ...

• Pathologic tearfulness after limbic encephalitis: A novel disorder and its neural basis 

  Zeman, Adam (HighWire, 2020-03-24)

  Objective: We investigated the nature and neural foundations of pathologic tearfulness in a uniquely large cohort of patients who had presented with autoimmune limbic encephalitis (aLE). Methods: We recruited 38 patients ...

• European Academy for medicine of ageing session participants' report on malnutrition assessment and diagnostic methods; an international survey 

  Hope, Suzy (Elsevier, 2020-02)

  Introduction: Malnutrition and nutrition-related diseases are associated with hospital admissions, disability, institutionalization, and mortality in older people. Specialists in Geriatric Medicine and nutrition evaluate ...

• The importance of different frailty domains in a population based sample in England 

  Sheridan, Ray (BioMed Central, 2020-01-15)

  Background: The aim was to estimate the prevalence of frailty and relative contribution of physical/balance, nutritive, cognitive and sensory frailty to important adverse health states (falls, physical activity levels, ...

• Neuropsychological Assessment of mTBI in Adults 

  Yates, Philip J; Reuben, Adam (Springer, 2019-11)

  Mild traumatic brain injury (mTBI), comprising 70–80% of all TBIs, is the commonest form of TBI, representing those injuries deemed to be at the lower end of the severity spectrum. In the general population, mTBI may occur ...

• POSU: A pilot study looking into the feasibility, safety and efficacy of a post-operative surgical unit for high-risk patients 

  Baldwin, Matthew; McCormick, Bruce; Foale, Mark; Belete, Martha; Chen, Connie; Williams, Helen; Stark, David; Matthews, Ed (Sage, 2019-12)

  In this ambitious quality improvement project, we investigated the possibility of using operating theatre post-operative recovery ward to care for high-risk patients overnight.

• Mechanical thrombectomy for acute ischaemic stroke: challenges and opportunities 

  James, Martin (2019-11)

• Patterns of postmeal insulin secretion in individuals with sulfonylurea- treated KCNJ11 neonatal diabetes show predominance of non- KATP- channel pathways 

  Bowman, Pamela; McDonald, Timothy J.; Knight, Bridget A; Flanagan, Sarah; Leveridge, Maria; Spaull, Steve R; Shields, Beverley M; Hammersley, Suzanne; Shepherd, Maggie; Andrews, Rob; Patel, Kashyap A; Hattersley, Andrew T. (BMJ, 2019-12)

  Insulin secretion in sulfonylurea-treated KCNJ11 permanent neonatal diabetes mellitus (PNDM) is thought to be mediated predominantly through amplifying non-KATP-channel pathways such as incretins. Affected individuals ...

• Cutaneous Leishmaniasis in a globetrotting explorer 

  Hunt, William (BMJ, 2019-12)

• A longitudinal study of epileptic seizures in Alzheimer's Disease 

  Zeman, Adam (Frontiers in Neurology, 2019-12)

  The prevalence of epileptic seizures is increased in patients in the clinical stages of Alzheimer's disease (AD) when compared to age-matched cognitively normal populations. In previously reported work from the Presentation ...

• Multicomponent hospital-led interventions to reduce hospital stay for older adults following elective surgery: a systematic review 

  Hemsley, Anthony; McGrath, John S.; Lovegrove, Chris J.; Thomas, David (National Institute of Health Research, 2019-12)

  Background: Elective older adult inpatient admissions are increasingly common. Older adults are at an elevated risk of adverse events in hospital, potentially increasing with lengthier hospital stay. Hospital-led ...

• Residual adrenal function in Autoimmune Addison’s Disease—effect of dual therapy with rituximab and depot tetracosactide 

  Vaidya, Bijay (Endocrine Society, 2020-04)

  In autoimmune Addison's disease (AAD), exogenous glucocorticoid (GC) therapy is an imperfect substitute for physiological GC secretion. Patients on long-term steroid replacement have increased morbidity, reduced life ...

• GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI 

  Hattersley, Andrew T. (American Association for the Advancement of Science, 2019-09)

  Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of ...

• Barriers to undertaking technical skills 

  Garwood, James (Wiley, 2020-04)

View more