Medical Services
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This community includes the research outputs from the Medical Services division which includes services such as: Cardiology, Diabetes, the Emergency Department, Neurology and Stroke. Browse the list of individual departments below.
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Intravenous immunoglobulin and rituximab versus placebo treatment of antibody-associated psychosis: study protocol of a randomised phase IIa double-blinded placebo-controlled trial (SINAPPS2)
(Biomed Central, 2019-06-07)Evidence is conflicting about a causal role of inflammation in psychosis and, specifically, regarding antibodies binding to neuronal membrane targets, especially N-methyl-D-aspartate receptors. NMDAR, LGI1 and GABA-A ... -
Genotype-phenotype correlation in a large English cohort of patients with autosomal recessive ichthyosis
(Wiley, 2019-06-06)Recessive forms of congenital ichthyosis encompass a group of rare inherited disorders of keratinization leading to dry, scaly skin. So far, 13 genes have been implicated, but there is a paucity of data on genotype-phenotype ... -
Maximising access to thrombectomy services for stroke in England: A modelling study
(Sage, 2019-03)Both intravenous thrombolysis (IVT) and intra-arterial endovascular thrombectomy (ET) improve the outcome of patients with acute ischaemic stroke, with endovascular thrombectomy being an option for those patients with large ... -
Complicated disease and response to initial therapy predicts early surgery in paediatric Crohn's disease: results from the Porto Group GROWTH study
(Oxford Academic, 2019-06-03)The ability to predict risk for poor outcomes in Crohn's disease (CD) would enable early treatment intensification. We aimed to identify children with CD with complications at baseline and throughout the study period who ... -
Genome-wide association study of microscopic colitis in the UK Biobank confirms immune-related pathogenesis
(Oxford Academic, 2019-05-24)The causes of microscopic colitis are currently poorly understood. Previous reports have found clinical associations with coeliac disease and genetic associations at the HLA locus on the ancestral 8.1 haplotype. We ... -
The relationships between symptoms, disability, perceived health and quality of life in amyotrophic lateral sclerosis/motor neuron disease
(Taylor & Francis, 2019-08)Objectives: Using the Wilson and Cleary model linking clinical variables to quality of life, we explored the associations between physical and psychological factors, disability, perceived health and quality of life in ... -
Reducing our carbon footprint and resource use on the Exeter Kidney Unit
(2019-07)Conference poster presented at the James Lovelock Centenary conference 'The Future of Global Systems Thinking', University of Exeter, 29th-31st July 2019. -
No health without planetary health
(2019-07) -
Diagnostic accuracy and usability of home calprotectin testing
(European Crohn's and Colitis Organisation, 2019-01)Faecal calprotectin (FC) is a reliable and non-invasive stool biomarker that is useful in monitoring inflammation in patients with IBD. Testing is routinely performed in a laboratory by enzyme-linked immunosorbent assay ... -
Dosing, durability of haemoglobin response and safety of iron isomaltoside in outpatients with gastrointestinal diseases
(2019-06)Poster presented at the British Society of Gastroenterology 2019 Annual Conference, 17th-20 June 2019. -
Fever and tachypnoea in a child
(BMJ, 2019-05-10) -
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
(Nature, 2019-05)Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses ... -
The use of adenosine stress perfusion cardiac magnetic resonance in determining incomplete revascularization post-coronary artery bypass grafting and the importance of anterior septal vessels
(European Society of Cardiology, 2019-04-10)Incomplete revascularization post-coronary artery bypass grafting (CABG) may occur in up to one quarter of patients,1 and meta-analyses suggest this is associated with poor outcomes.1,2 ESC guidelines now prioritize complete ... -
Renal nurses' lived experiences of discussions about sexuality
(Mark Allen Group, 2019-03)Renal teams focus predominantly on renal replacement therapy and physical symptom management, rather than psychological issues, such as mental health, body image or self-esteem. This study aims to increase understanding ... -
Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data
(Elsevier, 2019-06)Research using data-driven cluster analysis has proposed five subgroups of diabetes with differences in diabetes progression and risk of complications. We aimed to compare the clinical utility of this subgroup-based approach ... -
A specific CNOT1 mutation results in a novel syndrome of pancreatic agenesis and holoprosencephaly through impaired pancreatic and neurological development
(Cell Press, 2019-05)We report a recurrent CNOT1 de novo missense mutation, GenBank: NM_016284.4; c.1603C>T (p.Arg535Cys), resulting in a syndrome of pancreatic agenesis and abnormal forebrain development in three individuals and a similar ... -
Type 1 diabetes defined by severe insulin deficiency occurs after 30 years of age and is commonly treated as type 2 diabetes
(Springer, 2019-07)Late-onset type 1 diabetes can be difficult to identify. Measurement of endogenous insulin secretion using C-peptide provides a gold standard classification of diabetes type in longstanding diabetes that closely relates ...
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