• Estimating the effectiveness and cost-effectiveness of establishing additional endovascular thrombectomy stroke centres in England: a discrete event simulation 

  James, Martin A. (Biomed Central, 2019-11)

  We have previously modelled that the optimal number of comprehensive stroke centres (CSC) providing endovascular thrombectomy (EVT) in England would be 30 (net 6 new centres). We now estimate the relative effectiveness and ...

• A service evaluation between 2 week wait (2WW) skin cancer referrals via Teledermatology and the standard face-to-face pathway at a teaching hospital 

  Hunt, William T N (Wiley, 2019-11)

• Training opportunities in thoracic ultrasound for respiratory trainees: are current guidelines practical? 

  Batalla-Duran, Elizabeth (BMJ, 2019-10)

  Respiratory trainees in the UK face challenges in meeting current Royal College of Radiologists (RCR) Level 1 training requirements for thoracic ultrasound (TUS) competence, specified as attending 'at least one session per ...

• Getting home for haemodialysis: sharing experience to improve the patient experience 

  Dobbs, David (MAG Online Library, 2019-09)

  Home haemodialysis has many advantages when compared with conventional in-centre haemodialysis, but its uptake remains lower than predicted. This article explores the reasons for this low uptake, and the work of a Special ...

• Blinded physiological assessment of residual ischemia after successful angiographic percutaneous coronary intervention: the DEFINE PCI study 

  Sharp, Andrew S P (Elsevier, 2019-10)

  This study sought to evaluate the incidence and causes of an abnormal instantaneous wave-free ratio (iFR) after angiographically successful percutaneous coronary intervention (PCI).

• Sex differences in instantaneous wave-free ratio or fractional flow reserve-guided revascularization strategy 

  Sharp, Andrew S P (Elsevier, 2019-10)

  This study sought to evaluate sex differences in procedural characteristics and clinical outcomes of instantaneous wave-free ratio (iFR)- and fractional flow reserve (FFR)-guided revascularization strategies.

• Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14ARF, and TAU3 transcript expression and contribute to cognitive decline 

  Holley, Janet E; Gutowski, Nicholas J (Springer, 2019-10)

  The accumulation of senescent cells in tissues is causally linked to the development of several age-related diseases; the removal of senescent glial cells in animal models prevents Tau accumulation and cognitive decline. ...

• Rapid treatment of moderate to severe hypertension using a novel protocol in a single-centre, before and after interventional study 

  Bellenger, Nicholas G; Shore, Angela C; Sharp, Andrew S P (Nature, 2019-10)

  Rapid treatment to target in hypertension may have beneficial effects on long-term outcomes. This has led to a new recommendation in the 2018 European hypertension guidelines for patients with grade II/III hypertension to ...

• A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio 

  Hattersley, Andrew T; Weedon, Michael N; Murray, Anna; Shore, Angela C; Frayling, Timothy M; Wood, Andrew R (Oxford Academic, 2019-10)

  Raised albumin-creatinine ratio (ACR) is an indicator of microvascular damage and renal disease. We aimed to identify genetic variants associated with raised ACR and study the implications of carrying multiple ACR-raising ...

• Editorial: accelerated infliximab induction - it's time to settle the debate! Author's reply 

  Kennedy, Nicholas A (Wiley, 2019-11)

• Tiotropium add-on therapy reduces seasonal peaks of asthma worsening in adults with symptomatic severe asthma 

  Halpin, David M G (ESR Journals, 2020-01)

• Assessment of accuracy of an artificial intelligence algorithm to detect melanoma in images of skin lesions 

  McGrath, Emily; James, Rob (JAMA, 2019-10-02)

  A high proportion of suspicious pigmented skin lesions referred for investigation are benign. Techniques to improve the accuracy of melanoma diagnoses throughout the patient pathway are needed to reduce the pressure on ...

• Prospective evaluation of an ultrathin strut biodegradable polymer-coated sirolimus-eluting stent: 12 months' results from the S-FLEX UK registry 

  Sharp, Andrew (BMJ, 2019-10)

  OBJECTIVE: To prospectively evaluate safety and efficacy of the ultrathin strut biodegradable polymer-coated Supraflex sirolimus-eluting stent (S-SES) in 'real world' patient population requiring percutaneous coronary ...

• HLA-DQA1*05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's Disease 

  Kennedy, Nicholas A.; Heap, Graham; Bewshea, Claire M.; Chanclani, Neil; Walker, Gareth J.; Perry, Mandy H.; McDonald, Timothy J.; Goodhand, James R.; Ahmad, Tariq (Elsevier, 2020-01)

  Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The ability to ...

• Palliative care in liver disease: what does good look like? 

  Hudson, Ben (BMJ, 2019-09)

  The mortality rate from chronic liver disease in the UK is rising rapidly, and patients with advanced disease have a symptom burden comparable to or higher than that experienced in other life-limiting illnesses. While ...

• Association of elevated fractional exhaled nitric oxide concentration and blood eosinophil count with severe asthma exacerbations 

  Halpin, David M. (Biomed Central, 2019-08)

  Blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship of BEC and ...

• Practice pattern variability in the management of acute severe colitis: a UK provider survey 

  Kennedy, Nicholas A. (BMJ, 2019-08)

  Lack of comparative trial data on dosing regimens of infliximab in patients with acute severe ulcerative colitis (ASUC) failing intravenous corticosteroids has resulted in variability of rescue regimes in ASUC with potential ...

• Reply: intraoperative tissue perfusion measurement by laser speckle imaging: a potential aid for reducing postoperative complications in free flap breast reconstruction 

  To, Cynthia; Gooding, Kim; Cawrse, Nicholas H; Shore, Angela; Wilson, Andrew D (American Society of Plastic Surgeons, 2019-11)

• Airway management of patients with life threatening haemorrhage: principles of safe and effective care 

  Hudson, Tony (Springer, 2019-08)

  Airway care of the patient with life threatening haemorrhage presents many challenges during damage control resuscitation. The essential requirements are to maintain oxygenation at all stages of care and when necessary ...

• Perseverative negative thinking predicts depression in people with acute coronary syndrome 

  Gandhi, Manish (Elsevier, 2019-11)

  Depression is common in people who have experienced recent Acute Coronary Syndrome (ACS), and predicts worse medical outcomes. Mechanisms underpinning the development of depression and its association with poor medical ...

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