• EFSUMB Clinical Practice Guidelines for Point-of-Care Ultrasound: Part One (Common Heart and Pulmonary Applications) LONG VERSION 

  Jarman, R. D.; McDermott, C.; Colclough, A.; Bøtker, M.; Knudsen, L.; Harris, T.; Albaroudi, B.; Albaroudi, O.; Haddad, M.; Darke, R.; Berry, E.; Breslin, T.; Fitzpatrick, G.; Flanagan, L.; Olusanya, O.; Craver, D.; Omar, A.; Simpson, T.; Cherian, N.; Dore, M.; Prosen, G.; Kay, S.; Villén-Villegas, T.; Gargani, L.; Carley, S.; Woo, M.; Dupriez, F.; Hussain, A.; Via, G.; Connolly, J. A.; Peck, M.; Melniker, L.; Walden, A.; Attard Biancardi, M. A.; Żmijewska-Kaczor, O.; Lalande, E.; Geukens, P.; McLaughlin, R.; Olszynski, P.; Hoffmann, B.; Chin, E.; Muhr, C.; Kim, D. J.; Mercieca, A.; Shukla, D.; Hayward, S.; Smith, M.; Gaspari, R.; Smallwood, N.; Pes, P.; Tavazzi, G.; Corradi, F.; Lambert, M.; Morris, C.; Trauer, M.; Baker, K.; Bystrzycki, A.; Goudie, A.; Liu, R.; Rudd, L.; Dietrich, C. F.; Jenssen, C.; Sidhu, P. S. (Thieme Gruppe, 2022-10-13)

  AIMS:  To evaluate the evidence and produce a summary and recommendations for the most common heart and lung applications of point-of-care ultrasound (PoCUS). METHODS:  We reviewed 10 clinical domains/questions related to ...

• EFSUMB Clinical Practice Guidelines for Point-of-Care Ultrasound: Part One (Common Heart and Pulmonary Applications) SHORT VERSION 

  Jarman, R. D.; Colclough, A.; McDermott, C.; Bøtker, M.; Knudsen, L.; Harris, T.; Albaroudi, B.; Albaroudi, O.; Haddad, M.; Darke, R.; Berry, E.; Breslin, T.; Fitzpatrick, G.; Flanagan, L.; Olusanya, O.; Craver, D.; Omar, A.; Simpson, T.; Cherian, N.; Dore, M.; Prosen, G.; Kay, S.; Villén-Villegas, T.; Gargani, L.; Carley, S.; Woo, M.; Dupriez, F.; Hussain, A.; Via, G.; Connolly, J. A.; Peck, M.; Melniker, L.; Walden, A.; Attard Biancardi, M. A.; Żmijewska-Kaczor, O.; Lalande, E.; Geukens, P.; McLaughlin, R.; Olszynski, P.; Hoffmann, B.; Chin, E.; Muhr, C.; Kim, D. J.; Mercieca, A.; Shukla, D.; Hayward, S.; Smith, M.; Gaspari, R.; Smallwood, N.; Pes, P.; Tavazzi, G.; Corradi, F.; Lambert, M.; Morris, C.; Trauer, M.; Baker, K.; Bystrzycki, A.; Goudie, A.; Liu, R.; Rudd, L.; Dietrich, C. F.; Jenssen, C.; Sidhu, P. S. (Thieme Gruppe, 2022-10-13)

  OBJECTIVE:  To evaluate the evidence and produce a summary and recommendations for the most common heart and lung point-of-care ultrasound (PoCUS). METHODS:  We reviewed 10 clinical domains/questions related to common heart ...

• Hospital admissions from alcohol-related acute pancreatitis during the COVID-19 pandemic: A single-centre study 

  Mak, W. K.; Di Mauro, D.; Pearce, E.; Karran, L.; Myintmo, A.; Duckworth, J.; Orabi, A.; Lane, R.; Holloway, S.; Manzelli, A.; Mossadegh, S. (IS Publishing, 2022-09-06)

  BACKGROUND: The United Kingdom government introduced lockdown restrictions for the first time on 23 March 2020 due to coronavirus disease 2019 (COVID-19) pandemic. These were partially lifted on 15 June and further eased ...

• Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial 

  Kalra, P. R.; Cleland, J. G. F.; Petrie, M. C.; Thomson, E. A.; Kalra, P. A.; Squire, I. B.; Ahmed, F. Z.; Al-Mohammad, A.; Cowburn, P. J.; Foley, P. W. X.; Graham, F. J.; Japp, A. G.; Lane, R. E.; Lang, N. N.; Ludman, A. J.; Macdougall, I. C.; Pellicori, P.; Ray, R.; Robertson, M.; Seed, A.; Ford, I. (Elsevier, 2022-11-04)

  BACKGROUND: For patients with heart failure, reduced left ventricular ejection fraction and iron deficiency, intravenous ferric carboxymaltose administration improves quality of life and exercise capacity in the short-term ...

• Real-world experience of intravenous ferric derisomaltose evaluated through safety and efficacy reporting in the UK 

  Sinclair, R. C. F.; Nadaraja, S.; Kennedy, N. A.; Wakatsuki, M.; Bhandari, S. (Nature, 2022-11-07)

  Ferric derisomaltose (FDI; Monofer) is used in clinical practice to treat iron deficiency, but the safety and efficacy of FDI has not been robustly evaluated in a large real-world study. This retrospective, multicentre, ...

• Identifying type 1 and 2 diabetes in research datasets where classification biomarkers are unavailable: assessing the accuracy of published approaches 

  Thomas, N. J.; McGovern, A.; Young, K. G.; Sharp, S. A.; Weedon, M. N.; Hattersley, A. T.; Dennis, J.; Jones, A. G. (Elsevier, 2022-11-08)

  OBJECTIVE: We aimed to compare the performance of approaches for classifying insulin treated diabetes within research datasets without measured classification biomarkers, evaluated against two independent biological ...

• Infliximab and Tofacitinib Attenuate Neutralizing Antibody Responses Against SARS-CoV-2 Ancestral and Omicron Variants in Inflammatory Bowel Disease Patients Following 3 Doses of COVID-19 Vaccine 

  Liu, Z.; Alexander, J. L.; Lin, K. W.; Ahmad, T.; Pollock, K. M.; Powell, N. (Elsevier, 2022-10-19)

• Improving medical trainee recruitment: the south-west regional internal medical training recruitment event 2021 

  Maddox, N.; Smith, P.; Patten, S. (HighWire, 2022-07-09)

• The relationship between islet autoantibody status and the genetic risk of type 1 diabetes in adult-onset type 1 diabetes 

  Thomas, N. J.; Walkey, H. C.; Kaur, A.; Misra, S.; Oliver, N. S.; Colclough, K.; Weedon, M. N.; Johnston, D. G.; Hattersley, A. T.; Patel, K. A. (Springer, 2022-11-10)

  AIMS/HYPOTHESIS: The reason for the observed lower rate of islet autoantibody positivity in clinician-diagnosed adult-onset vs childhood-onset type 1 diabetes is not known. We aimed to explore this by assessing the genetic ...

• The impact of population-level HbA(1c) screening on reducing diabetes diagnostic delay in middle-aged adults: a UK Biobank analysis 

  Young, K. G.; McGovern, A. P.; Barroso, I.; Hattersley, A. T.; Jones, A. G.; Shields, B. M.; Thomas, N. J.; Dennis, J. M. (Springer, 2022-11-22)

  AIMS/HYPOTHESIS: Screening programmes can detect cases of undiagnosed diabetes earlier than symptomatic or incidental diagnosis. However, the improvement in time to diagnosis achieved by screening programmes compared with ...

• Routine Islet Autoantibody Testing in Clinically Diagnosed Adult-Onset Type 1 Diabetes Can Help Identify Misclassification and the Possibility of Successful Insulin Cessation 

  Eason, R. J.; Thomas, N. J.; Hill, A. V.; Knight, B. A.; Carr, A.; Hattersley, A. T.; McDonald, T. J.; Shields, B. M.; Jones, A. G. (American Diabetes Association, 2022-10-07)

  OBJECTIVE: Recent joint American Diabetes Association and European Association for the Study of Diabetes guidelines recommend routine islet autoantibody testing in all adults newly diagnosed with type 1 diabetes. We aimed ...

• Patient and public involvement and engagement with cardiac arrest survivors 

  Coppola, A.; Halliday, C.; Jones, M.; Houghton, R.; Johnson, M.; Sillis, N.; Johnson, M.; Sillis, D.; Endacott, R. (The College of Paramedics, 2022-06-01)

  BACKGROUND: Patient and public involvement and engagement (PPIE) with cardiac arrest survivors is an essential component of research to strengthen development, design, delivery and dissemination to ensure research priorities ...

• Tuberous xanthoma secondary to homozygous familial hypercholesterolaemia: a life-threatening diagnosis 

  Kazmi, A.; Frewen, J.; McDonald, B.; Davison, J.; O'Toole, E. (Wiley, 2022-12-01)

  We report the case of a 9-year-old girl who presented with asymptomatic lesions on the extensor surfaces of the elbows and knees, in keeping with tuberous xanthoma. She was investigated and diagnosed with homozygous familial ...

• Surgical Methods of Fistula Closure in fistulating perianal Crohn's Disease 

  Khalil, I.; Bethune, R. (Wiley, 2022-11-25)

• Calcium-channel blockers: Clinical outcome associations with reported pharmacogenetics variants in 32 000 patients 

  Türkmen, D.; Masoli, J. A. H.; Delgado, J.; Kuo, C. L.; Bowden, J.; Melzer, D.; Pilling, L. C. (Wiley, 2022-09-22)

  AIMS: Pharmacogenetic variants impact dihydropyridine calcium-channel blockers (dCCBs; e.g., amlodipine) treatment efficacy, yet evidence on clinical outcomes in routine primary care is limited. Reported associations in ...

• Overactive bladder: not just a normal part of getting older 

  Carpenter, L.; Campain, N. J. (Mark Allen Group, 2022-10-13)

  Overactive bladder (OAB) is a common yet under-reported condition affecting both men and women. Prevalence rises with age, but OAB can affect people of any age. It is associated with increased physical and mental health ...

• COVID-19 pandemic interim Foundation Year 1 post and confidence in core skills and competencies: a longitudinal survey 

  Gatti, C. A.; Parker-Conway, K.; Okorie, M. (BMJ, 2022-11-02)

  OBJECTIVES: The interim Foundation Year 1 (FiY1) post was created in response to the COVID-19 pandemic to help bolster the workforce and manage increased clinical pressures. This study aimed to assess the impact of the ...

• Prevalence of skin pressure injury in critical care patients in the UK: results of a single-day point prevalence evaluation in adult critically ill patients 

  Rubulotta, F.; Brett, S.; Boulanger, C.; Blackwood, B.; Deschepper, M.; Labeau, S. O.; Blot, S. (BMJ, 2022-11-23)

  OBJECTIVES: Hospital-acquired pressure injuries (PIs) are a source of morbidity and mortality, and many are potentially preventable. DESIGN: This study prospectively evaluated the prevalence and the associated factors of ...

• Longitudinal comparisons of mental health, burnout and well-being in patient-facing, non-patient-facing healthcare professionals and non-healthcare professionals during the COVID-19 pandemic: findings from the CoPE-HCP study 

  Kapil, V.; Collett, G.; Godec, T.; Gupta, J.; Maniero, C.; Ng, S. M.; McIntosh, I.; Kumar, A.; Nair, S.; Kotecha, A.; Janmohamed, A.; Antoniou, S.; Khan, R.; Khanji, M. Y.; Siddiqui, I.; Gupta, A. (Cambridge University Press, 2022-09-27)

  BACKGROUND: The COVID-19 pandemic may disproportionately affect the mental health of healthcare professionals (HCPs), especially patient-facing HCPs. AIMS: To longitudinally examine mental health in HCPs versus non-HCPs, ...

• Genomics and multimorbidity 

  Masoli, J. A. H.; Pilling, L. C.; Frayling, T. M. (Oxford University Press, 2022-12-05)

  Multimorbidity has increased in prevalence world-wide. It is anticipated to affect over 1 in 6 of the UK population by 2035 and is now recognised as a global priority for health research. Genomic medicine has rapidly ...

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