• Ambulatory care management of 69 patients with acute severe ulcerative colitis in comparison to 695 inpatients: insights from a multicentre UK cohort study 

  Sebastian, S.; Patel, K. V.; Segal, J. P.; Subramanian, S.; Conley, T. E.; Gonzalez, H. A.; Kent, A. J.; Saifuddin, A.; Hicks, L.; Mehta, S.; Bhala, N.; Brookes, M. J.; Lamb, C. A.; Kennedy, N. A.; Walker, G. J. (BMJ Publishing Group, 2022-01-01)

  INTRODUCTION: Acute severe ulcerative colitis (ASUC) traditionally requires inpatient hospital management for intravenous therapies and/or colectomy. Ambulatory ASUC care has not yet been evaluated in large cohorts. AIMS: ...

• Rapid, patient-led titration of basal insulin can be used to achieve tight glycaemic control in gestational diabetes mellitus with insulin resistance 

  Mayne, I.; Thomas, N.; McGovern, A. (BMJ, 2022-03-10)

  A woman with gestational diabetes mellitus (GDM) and significant insulin resistance in her third pregnancy was diagnosed with a fasting blood glucose reading of 5.7 mmol/L (103 mg/dL) at 28+1 weeks gestation and referred ...

• Bickerstaff brainstem encephalitis: clinical, neurophysiological, laboratory and postmortem findings of a case presenting as encephalomyelitis 

  Imam, I.; Sarrigiannis, P. G.; Shivane, A. G. (BMJ, 2022-02-02)

  Our patient was admitted to hospital with a 1-week history of an upper respiratory tract infection and a rapidly progressive encephalopathy dominated by brainstem features and widespread areflexia. Her antiganglioside ...

• Is there a role for botulinum toxin A in the emergency setting for delayed abdominal wall closure in the management of the open abdomen? A systematic review 

  Luton, O. W.; Mortimer, M.; Hopkins, L.; Robinson, D.; Egeler, C.; Smart, N. J.; Harries, R. (Royal College of Surgeons, 2022-02-17)

  INTRODUCTION: Emergency laparotomy for either trauma or non-trauma indications is common and management is varied. Use of the open abdomen technique allowing for planned re-look is an option; however, performing delayed ...

• Clinician preferences in the treatment of acutely symptomatic hernia: the 'MASH' survey 

  O'Connor, O. M.; Burns, F. A.; Proctor, V. K.; Green, S. K.; Sayers, A. E.; Smart, N. J.; Lee, M. J. (Royal College of Surgeons, 2022-02-23)

  INTRODUCTION: There is limited high-quality evidence to guide the management of acute hernia presentation. The aim of this study was to survey surgeons to assess current trends in assessment, treatment strategy and operative ...

• Elective splenectomy in patients with non-Hodgkin lymphoma: Does the size of the spleen affect surgical outcomes? 

  Mauro, D. D.; Gelsomino, M.; Fasano, A.; Wajed, S.; Manzelli, A. (Korean Association of Hepato-Biliary-Pancreatic Surgery, 2022-02-16)

  BACKGROUNDS/AIMS: Splenectomy in patients with non-Hodgkin lymphoma (NHL) is performed to relieve abdominal symptoms, treat hypersplenism or confirm diagnosis. Excision of a very large spleen is technically challenging and ...

• Postradioiodine Graves' management: The PRAGMA study 

  Perros, P.; Basu, A.; Boelaert, K.; Dayan, C.; Vaidya, B.; Williams, G. R.; Lazarus, J. H.; Hickey, J.; Drake, W. M.; Crown, A.; Orme, S. M.; Johnson, A.; Ray, D. W.; Leese, G. P.; Jones, T. H.; Abraham, P.; Grossman, A.; Rees, A.; Razvi, S.; Gibb, F. W.; Moran, C.; Madathil, A.; Žarković, M. P.; Plummer, Z.; Jarvis, S.; Falinska, A.; Velusamy, A.; Sanderson, V.; Pariani, N.; Atkin, S. L.; Syed, A. A.; Sathyapalan, T.; Nag, S.; Gilbert, J.; Gleeson, H.; Levy, M. J.; Johnston, C.; Sturrock, N.; Bennett, S.; Mishra, B.; Malik, I.; Karavitaki, N. (Wiley, 2022-03-11)

  OBJECTIVE: Thyroid status in the months following radioiodine (RI) treatment for Graves' disease can be unstable. Our objective was to quantify frequency of abnormal thyroid function post-RI and compare effectiveness of ...

• Evaluation of Evidence for Pathogenicity Demonstrates that BLK, KLF11 and PAX4 Should not be Included in Diagnostic Testing for MODY 

  Laver, T. W.; Wakeling, M. N.; Knox, O.; Colclough, K.; Wright, C. F.; Ellard, S.; Hattersley, A. T.; Weedon, M. N.; Patel, K. A. (American Diabetes Association, 2022-02-02)

  Maturity Onset Diabetes of the Young (MODY) is an autosomal dominant form of monogenic diabetes, reported to be caused by variants in 16 genes. Concern has been raised about whether variants in BLK (MODY11), KLF11 (MODY7) ...

• Bronchiolitis 

  Gill, P. J.; Chanchlani, N.; Mahant, S. (Canadian Medical Association, 2022-02-14)

• Editor's Choice - February 2022 

  Smart, N. (Wiley, 2022-02-01)

• Editor's Choice - January 2022 

  Smart, N. (Wiley, 2022-01-01)

• A multiple sclerosis nurse specialist narrative, focusing on supporting people to manage cognitive changes 

  Jarrett, Louise (Mark Allen Group, 2022-01-01)

  Background: Cognitive changes are common in people with multiple sclerosis (MS). Interventions from health professionals can focus on assessment, measurement and advice on management strategies. Such interventions are often ...

• Providing information, care and support to IBD patients during the pandemic 

  Cairnes, V. (MA Healthcare, 2022-03-24)

  Vida Cairnes, Lead Inflammatory Bowel Disease (IBD) Nurse Specialist, Royal Devon and Exeter Hospital, and the Exeter IBD Specialist Nursing Team were runners-up in the Gastrointestinal/IBD Nurse of the Year category of ...

• Hospital at Home admission avoidance with comprehensive geriatric assessment to maintain living at home for people aged 65 years and over: a RCT 

  Shepperd, S.; Cradduck-Bamford, A.; Butler, C.; Ellis, G.; Godfrey, M.; Gray, A.; Hemsley, A.; Khanna, P.; Langhorne, P.; Mäkelä, P.; Mort, S.; Ramsay, S.; Schiff, R.; Singh, S.; Smith, S.; Stott, D. J.; Tsiachristas, A.; Wilkinson, A.; Yu, L. M.; Young, J. (NIHR Journals Library, 2022-01-01)

  BACKGROUND: Evidence is required to guide the redesign of health care for older people who require hospital admission. OBJECTIVES: We assessed the clinical effectiveness and cost-effectiveness of geriatrician-led admission ...

• Epidemiology and outcome of pressure injuries in critically ill patients with chronic obstructive pulmonary disease: A propensity score adjusted analysis 

  Martin-Loeches, I.; Rose, L.; Afonso, E.; Benbenishty, J.; Blackwood, B.; Boulanger, C.; Calvino-Gunther, S.; Chaboyer, W.; Coyer, F.; Llaurado-Serra, M.; Lin, F.; Rubulotta, F.; Williams, G.; Deschepper, M.; Francois, G.; Labeau, S. O.; Blot, S. I. (Elsevier, 2022-03-08)

  BACKGROUND: Pressure injuries are a frequent complication in intensive care unit (ICU) patients, especially in those with comorbid conditions such as chronic obstructive pulmonary disease (COPD). Yet no epidemiological ...

• P361 PREPARE-IBD: Physician Responses to disease Flares and Patient Adaptation in Relation to Events in Inflammatory Bowel Disease during the COVID-19 pandemic: A multicentre cohort analysis 

  Saifuddin, A; Kent, A; Mehta, S; Hicks, L; Gonzalez, H; Segal, J; Brooks, M; Subramanian, S; Bhala, N; Conley, T; Patel, K; Lamb, C; Walker, G; Kennedy, N; Sebastian, S; collaborators, PREPARE-IBD (Oxford University Press, 2022-01-21)

  The COVID-19 pandemic continues to pose complex problems across Europe and the world, with rising numbers of infections and the ongoing need for drastic public health interventions. This is difficult for patients with ...

• Type 1 Diabetes Patients With Different Residual Beta-Cell Function but Similar Age, HBA1c, and Cardiorespiratory Fitness Have Differing Exercise-Induced Angiogenic Cell Mobilisation 

  Taylor, G. S.; Shaw, A.; Scragg, J. H.; Smith, K.; Campbell, M. D.; McDonald, T. J.; Shaw, J. A.; Ross, M. D.; West, D. J. (Frontiers Media, 2022-02-11)

  BACKGROUND: Many individuals with type 1 diabetes retain residual beta-cell function. Sustained endogenous insulin and C-peptide secretion is associated with reduced diabetes related complications, but underlying mechanisms ...

• Clinical and genetic heterogeneity of HNF4A/HNF1A mutations in a multicentre paediatric cohort with hyperinsulinaemic hypoglycaemia 

  McGlacken-Byrne, S. M.; Mohammad, J. K.; Conlon, N.; Gubaeva, D.; Siersbæk, J.; Schou, A. J.; Demirbilek, H.; Dastamani, A.; Houghton, J. A. L.; Brusgaard, K.; Melikyan, M.; Christesen, H.; Flanagan, S. E.; Murphy, N. P.; Shah, P. (BioScientifica, 2022-02-22)

  OBJECTIVE: The phenotype mediated by HNF4A/HNF1A mutations is variable and includes diazoxide-responsive hyperinsulinaemic hypoglycaemia (HH) and maturity-onset diabetes of the young (MODY). DESIGN: We characterised an ...

• Understanding the pathogenesis of lean non-autoimmune diabetes in an African population with newly diagnosed diabetes 

  Kibirige, D.; Sekitoleko, I.; Lumu, W.; Jones, A. G.; Hattersley, A. T.; Smeeth, L.; Nyirenda, M. J. (Springer, 2022-04-01)

  AIMS/HYPOTHESIS: Apparent type 2 diabetes is increasingly reported in lean adult individuals in sub-Saharan Africa. However, studies undertaking robust clinical and metabolic characterisation of lean individuals with ...

• Capturing the real-world benefit of residual β-cell function during clinically important time-periods in established Type 1 diabetes 

  Taylor, G. S.; Shaw, A. C.; Smith, K.; Wason, J.; McDonald, T. J.; Oram, R. A.; Stevenson, E.; Shaw, J. A. M.; West, D. J. (Wiley, 2022-02-18)

  AIMS: Many individuals with type 1 diabetes retain residual β-cell function, with increased endogenous insulin secretion associated with reduced hyperglycaemia, hypoglycaemia and glycaemic variability. However, it is unknown ...

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