• Beta cells in type 1 diabetes: mass and function; sleeping or dead? 

  Oram, Richard (Springer, 2019-04)

  Histological analysis of donor pancreases coupled with measurement of serum C-peptide in clinical cohorts has challenged the idea that all beta cells are eventually destroyed in type 1 diabetes. These findings have raised ...

• Inflammatory bowel disease in children and adolescents. 

  Chanchlani, Neil; Russell, Richard K, (Canadian Medical Association, 2019-02-11)

• Systematic review of definitions and outcome measures for return of bowel function after gastrointestinal surgery. 

  Vallance, A E (Wiley, 2018-10)

  Ileus is common after gastrointestinal surgery and has been identified as a research priority. Several issues have limited previous research, including a widely accepted definition and agreed outcome measure. This review ...

• Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment 

  Sharp, Andrew (Elsevier, 2019-02-05)

  Physicians are not always comfortable deferring treatment of a stenosis in the left anterior descending (LAD) artery because of the perception that there is a high risk of major adverse cardiac events (MACE). The authors ...

• Systemic agents for psoriasis and their relevance to primary care 

  Hunt, William; Frow, Helen (Royal College of General Practitioners, 2019-02)

  Psoriasis is a common chronic autoimmune inflammatory disease. There is an increasing range of systemic agents prescribed by specialists in the management of psoriasis. Thus, it is important for clinicians to become familiar ...

• Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis. 

  Oram, Richard (American Diabetes Association, 2019-02)

  Previously generated genetic risk scores (GRSs) for type 1 diabetes (T1D) have not captured all known information at non-HLA loci or, particularly, at HLA risk loci. We aimed to more completely incorporate HLA alleles, ...

• Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting 

  Hattersley, Andrew T. (Elsevier, 2019-02-07)

  More than 100,000 genetic variants are classified as disease causing in public databases. However, the true penetrance of many of these rare alleles is uncertain and might be over-estimated by clinical ascertainment. Here, ...

• Intraoperative Tissue Perfusion Measurement by Laser Speckle Imaging: A Potential Aid for Reducing Postoperative Complications in Free Flap Breast Reconstruction 

  To, Cynthia; Shore, Angela; Wilson, Andrew D. (Wolters Kluwer, 2019-02)

  Adequate tissue perfusion is essential to minimize postoperative complications following microsurgery. Intraoperative knowledge of tissue perfusion could aid surgical decision-making and result in reduced complications. ...

• Suspected ST segment elevation myocardial infarction referred for primary angioplasty: a masquerader 

  Yennu Nandan, Abhivrath; Mukundu Nagesh, Navin; Gandhi, Manish (BMJ, 2019-01-14)

  A 50-year-old man collapsed at the roadside with retrosternal pain, shortness of breath and generalised weakness. An ECG in the emergency department was reported as demonstrating ST segment elevation of up to 1.5 mm in ...

• Diagnostic accuracy of the T-MACS decision aid with a contemporary point-of-care troponin assay 

  Appelboam, Andy (BMJ, 2019-01-12)

  The rapid turnaround time of point-of-care (POC) cardiac troponin (cTn) assays is highly attractive for crowded emergency departments (EDs). We evaluated the diagnostic accuracy of the Troponin-only Manchester Acute Coronary ...

• A prospective observational study of iron isomaltoside in haemodialysis patients with chronic kidney disease treated for iron deficiency (DINO). 

  Moore, Jason (BioMed Central, 2019-01-10)

  Iron deficiency is frequent in haemodialysis (HD) patients with chronic kidney disease (CKD), and intravenous iron is an established therapy for these patients. This study assessed treatment routine, effectiveness, and ...

• GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation 

  Shepherd, Maggie; Hattersley, Andrew (Cell Press, 2019-01-08)

  Heterozygous de novo mutations in GATA6 are the most frequent cause of pancreatic agenesis in humans. In mice, however, a similar phenotype requires the biallelic loss of Gata6 and its paralog Gata4. To elaborate the ...

• The feasibility of online video calling to engage patients with cystic fibrosis in exercise training 

  Tomlinson, Owen; Shelley, James; Trott, Jayne; Bowhay, Ben; Chauhan, Rohan; Sheldon, Christopher David (Sage, 2019)

  Physical activity (PA), including structured exercise is an essential component in the management of cystic fibrosis (CF). The use of telehealth such as video-calling may be a useful method for the delivery of exercise and ...

• Home visits: A new screening tool for frailty? A retrospective exploratory study. 

  Jones, Lindsay (Academy of Family Physicians India, 2018-09)

  In the United Kingdom, the new NHS contract for primary care mandates that practices use the Electronic Frailty Index (EFI) to screen for frailty and apply clinical judgment, based on knowledge of the patient, to decide ...

• Future Roadmaps for Precision Medicine Applied to Diabetes: Rising to the Challenge of Heterogeneity. 

  Hattersley, Andrew T. (Hindawi, 2018-11)

  Precision medicine, the concept that specific treatments can be targeted to groups of individuals with specific genetic, cellular, or molecular features, is a key aspect of modern healthcare, and its use is rapidly expanding. ...

• COPD Biomarkers and their Interpretation. 

  Halpin, David M (American Thoracic Society, 2018-12-28)

  The pathology and impact of COPD results from an abnormal inflammatory process resulting in tissue damage with ineffective repair in response to toxic inhalants (especially cigarette smoke). Identification of mechanisms ...

• Response to Prakash et al. 

  Turner, Claire L.; Donohoe, Mollie E; Brooke, Antonia M (Nature, 2018-12-21)

• Kufs disease due to mutation of CLN6: clinical, pathological and molecular genetic features. 

  Zeman, Adam; Rankin, Julia (Oxford Journals, 2018-12-15)

  Kufs disease is the major adult form of neuronal ceroid lipofuscinosis, but is rare and difficult to diagnose. Diagnosis was traditionally dependent on the demonstration of characteristic storage material, but distinction ...

• Renal artery sympathetic denervation: Back on track! 

  Sharp, Andrew (Oxford Academic, 2018-12-07)

• Testing of a novel Valsalva Assist Device with supine and modified positions in healthy volunteers. 

  FitzGerald, Isabel; Appelboam, Andy (BMJ, 2018-12-01)

  The Valsalva manoeuvre (VM) is used to treat supraventricular tachycardia (SVT) by inducing a vagal response (drop in HR). There is debate as to the best position in which to carry out the VM and how the strain should be ...

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