Medical Services
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This community includes the research outputs from the Medical Services division which includes services such as: Cardiology, Diabetes, the Emergency Department, Neurology and Stroke. Browse the list of individual departments below.
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Prospective evaluation of an ultrathin strut biodegradable polymer-coated sirolimus-eluting stent: 12 months' results from the S-FLEX UK registry
(BMJ, 2019-10)OBJECTIVE: To prospectively evaluate safety and efficacy of the ultrathin strut biodegradable polymer-coated Supraflex sirolimus-eluting stent (S-SES) in 'real world' patient population requiring percutaneous coronary ... -
HLA-DQA1*05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's Disease
(Elsevier, 2020-01)Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The ability to ... -
Palliative care in liver disease: what does good look like?
(BMJ, 2019-09)The mortality rate from chronic liver disease in the UK is rising rapidly, and patients with advanced disease have a symptom burden comparable to or higher than that experienced in other life-limiting illnesses. While ... -
Association of elevated fractional exhaled nitric oxide concentration and blood eosinophil count with severe asthma exacerbations
(Biomed Central, 2019-08)Blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship of BEC and ... -
Practice pattern variability in the management of acute severe colitis: a UK provider survey
(BMJ, 2019-08)Lack of comparative trial data on dosing regimens of infliximab in patients with acute severe ulcerative colitis (ASUC) failing intravenous corticosteroids has resulted in variability of rescue regimes in ASUC with potential ... -
Reply: intraoperative tissue perfusion measurement by laser speckle imaging: a potential aid for reducing postoperative complications in free flap breast reconstruction
(American Society of Plastic Surgeons, 2019-11) -
Airway management of patients with life threatening haemorrhage: principles of safe and effective care
(Springer, 2019-08)Airway care of the patient with life threatening haemorrhage presents many challenges during damage control resuscitation. The essential requirements are to maintain oxygenation at all stages of care and when necessary ... -
Perseverative negative thinking predicts depression in people with acute coronary syndrome
(Elsevier, 2019-11)Depression is common in people who have experienced recent Acute Coronary Syndrome (ACS), and predicts worse medical outcomes. Mechanisms underpinning the development of depression and its association with poor medical ... -
Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years
(BMJ, 2019-09)OBJECTIVE: To develop and validate multivariable clinical diagnostic models to assist distinguishing between type 1 and type 2 diabetes in adults aged 18-50. DESIGN: Multivariable logistic regression analysis was used ... -
British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults
(BMJ, 2019-12)Ulcerative colitis and Crohn's disease are the principal forms of inflammatory bowel disease. Both represent chronic inflammation of the gastrointestinal tract, which displays heterogeneity in inflammatory and symptomatic ... -
Axillary web syndrome induced by physical exertion
(Wiley, 2019-09) -
MNS1 variant associated with situs inversus and male infertility
(Nature, 2020-01)Ciliopathy disorders due to abnormalities of motile cilia encompass a range of autosomal recessive conditions typified by chronic otosinopulmonary disease, infertility, situs abnormalities and hydrocephalus. Using a ... -
Can clinical audits be enhanced by pathway simulation and machine learning? An example from the acute stroke pathway
(BMJ, 2019-09)OBJECTIVE: To evaluate the application of clinical pathway simulation in machine learning, using clinical audit data, in order to identify key drivers for improving use and speed of thrombolysis at individual hospitals. -
HNF1B mutations are associated with a Gitelman-like tubulopathy that develops during childhood
(Elsevier, 2019-05)Mutations in the transcription factor hepatocyte nuclear factor 1B (HNF1B) are the most common inherited cause of renal malformations, yet also associated with renal tubular dysfunction, most prominently magnesium wasting ... -
Chronic Obstructive Pulmonary Disease and work: is it time to stop?
(AJRCCM, 2019-11) -
Misinterpretation of time to first event curves can lead to inappropriate treatment
(ESR Journals, 2019-09) -
Cognitive, neurological and behavioral features in adults with KCNJ11 neonatal diabetes
(American Diabetes Association, 2019-02)Central nervous system (CNS) features in children with permanent neonatal diabetes (PNDM) due to KCNJ11 mutations have a major impact on affected families. Sulfonylurea therapy achieves outstanding metabolic control but ... -
Novel nonsense variants in SLURP1 and DSG1 cause palmoplantar keratoderma in Pakistani families
(Biomed Central, 2019-08)Inherited palmoplantar keratodermas (PPKs) are clinically and genetically heterogeneous and phenotypically diverse group of genodermatoses characterized by hyperkeratosis of the palms and soles. More than 20 genes have ...
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