• Primary care faecal calprotectin testing in children with suspected inflammatory bowel disease: a diagnostic accuracy study 

  Walker, Gareth; Chanchlani, Neil; Thomas, Amanda; Lin, Simeng; Moore, Lucy; Heerasing, Neel; Hendy, Peter; Abdelrahim, Mohamad; Mole, Sean; Perry, Mandy; McDonald, Timothy J.; Bewshea, Claire M.; Hart, James W.; Ahmad, Tariq; Goodhand, James R.; Kennedy, Nicholas A. (BMJ, 2020-10)

  Objective: To determine the diagnostic accuracy of calprotectin to diagnose inflammatory bowel disease (IBD) in children in whom general practitioners (GPs) suspected IBD. Design: Prospective observational cohort study ...

• The impact of an integrated heart failure service in a medium-sized district general hospital 

  Hawley, Alasdair; He, Jingzhou (BMJ, 2020-05)

  Objectives: Assessing the impact of a new integrated heart failure service (IHFS) in a medium-sized district general hospital (DGH) on heart failure (HF) mortality, readmission rates, and provision of HF care. Methods: ...

• Limit of detection of troponin discharge strategy versus usual care: randomised controlled trial 

  Reuben, Adam (BMJ, 2020-10)

  Introduction: The clinical effectiveness of a 'rule-out' acute coronary syndrome (ACS) strategy for emergency department patients with chest pain, incorporating a single undetectable high-sensitivity cardiac troponin ...

• The experiences of hospital staff who provide care for people living with dementia: A systematic review and synthesis of qualitative studies 

  Gwernan-Jones, R.; Abbott, R.; Rogers, M.; Green, C.; Ball, S.; Hemsley, Anthony; Cheeseman, Debbie; Moore, D. A.; Thompson Coon, J. (Wiley, 2020-05-15)

  Aims and objectives: To systematically review and synthesise qualitative data from studies exploring the experiences of hospital staff who care for people living with dementia (Plwd). Background: In hospital, the number ...

• Does Obesity Cause Thyroid Cancer? A Mendelian Randomization Study 

  Fussey, Jonathan Mark; Beaumont, Robin N.; Wood, Andrew R; Vaidya, Bijay; Smith, Joel; Tyrrell, Jessica (Oxford University Press, 2020-07-01)

  Background: The incidence of thyroid cancer is rising, and relatively little is known about modifiable risk factors for the condition. Observational studies have suggested a link between adiposity and thyroid cancer; ...

• Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis 

  Vaidya, Bijay; Knight, Bridget (Elsevier Science, 2020-06)

  Background: Adequate transplacental passage of maternal thyroid hormone is important for normal fetal growth and development. Maternal overt hypothyroidism and hyperthyroidism are associated with low birthweight, but ...

• The cost of providing mechanical thrombectomy in the UK NHS: a micro-costing study 

  James, Martin (HighWire, 2020-05)

  Introduction: The clinical efficacy and cost-effectiveness of mechanical thrombectomy (MT) for the treatment of large vessel occlusion stroke is well established, but uncertainty remains around the true cost of delivering ...

• APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort 

  Pilling, L. C.; Atkins, J. L.; Masoli, Jane A.; Delgado, J.; Melzer, David (Oxford University Press, 2020-05-26)

• Ethnic differences in adiposity and diabetes risk - insights from genetic studies 

  Yaghootkar, Hanieh (Wiley, 2020-09)

  Type 2 diabetes is more common in non-Europeans and starts at a younger age and at lower BMI cut-offs. This review discusses the insights from genetic studies about pathophysiological mechanisms which determine risk of ...

• Rectal stump management in inflammatory bowel disease: a cohort study, systematic review and proportional analysis of perioperative complications 

  Lawday, Samuel; Leaning, Matthew; Flannery, Oliver; Summers, S.; Goodhand, James; Bethune, Rob; Antoniou, Stavros A. (Springer, 2020-07)

  Background: The aim of this study was to analyse local single-institution data and perform a systematic review of the literature to calculate precise risk estimates of rectal stump-related morbidity and mortality following ...

• Research criteria for the diagnosis of prodromal dementia with Lewy bodies 

  Ballard, Clive (HighWire, 2020-04-28)

  The prodromal phase of dementia with Lewy bodies (DLB) includes (1) mild cognitive impairment (MCI), (2) delirium-onset, and (3) psychiatric-onset presentations. The purpose of our review is to determine whether there is ...

• Visual hallucinations in neurological and ophthalmological disease: pathophysiology and management 

  Ballard, Clive (BMJ, 2020-05)

  Visual hallucinations are common in older people and are especially associated with ophthalmological and neurological disorders, including dementia and Parkinson's disease. Uncertainties remain whether there is a single ...

• Juvenile diabetes and visual impairment: Wolfram syndrome 

  Ellard, Sian; De Franco, Elisa (PubMed Central, 2019-10-01)

• An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders 

  Ballard, Clive (Nature Publishing Group, 2020-05)

  Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for population screening. Therefore, ...

• Real-World Effectiveness of Tofacitinib for Moderate to Severe Ulcerative Colitis: A Multi-Centre UK Experience 

  Chee, Desmond; Goodhand, James R.; Ahmad, Tariq; Kennedy, Nicholas A. (Oxford University Press, 2020-04-13)

  Background: Tofacitinib is a partially selective Janus kinase inhibitor approved for the treatment of refractory moderate to severe ulcerative colitis (UC). We sought to define the effectiveness and adverse effects of ...

• Congenital hyperinsulinism due to mutations in HNF1A 

  Colclough, Kevin (Elsevier Science, 2020-06)

  Congenital hyperinsulinism is a rare but significant cause of severe and persistent hypoglycaemia in infancy. Although a biphasic phenotype of congenital hyperinsulinism in infancy followed by Maturity-Onset Diabetes of ...

• The importance of language in engagement between health-care professionals and people living with obesity: a joint consensus statement 

  Strain, W David (Elsevier Science, 2020-05)

  Obesity is a chronic condition that requires long-term management and is associated with unprecedented stigma in different settings, including during interactions with the health-care system. This stigma has a negative ...

• Persistent plaque on the right leg 

  Xie, Fangyi; Williams, Penelope (Wiley, 2020-04-28)

• Reducing the hidden burden of severe asthma: recognition and referrals from primary practice 

  Halpin, David M (Taylor & Francis, 2020-05-13)

  Since their introduction many decades ago, systemic corticosteroids have become a mainstay treatment for asthma. Despite being a highly effective therapy, corticosteroids can cause significant adverse effects in patients. ...

• Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium 

  Hudson, Michelle; Perry, Mandy; Hattersley, Andrew T.; McDonald, Timothy J. (Springer, 2019-09)

  Aims/hypothesis: Here, we describe the characteristics of the Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) epidemiological cohorts at baseline and follow-up examinations (18, ...

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