• The use of adenosine stress perfusion cardiac magnetic resonance in determining incomplete revascularization post-coronary artery bypass grafting and the importance of anterior septal vessels 

  Le Page, Pierre T.; Bellenger, Nick G. (European Society of Cardiology, 2019-04-10)

  Incomplete revascularization post-coronary artery bypass grafting (CABG) may occur in up to one quarter of patients,1 and meta-analyses suggest this is associated with poor outcomes.1,2 ESC guidelines now prioritize complete ...

• Renal nurses' lived experiences of discussions about sexuality 

  Hough, Maxine; Githens-Mazer, Gayle; Lovegrove, Chris; Oram, Richard; Shepherd, Maggie (Mark Allen Group, 2019-03)

  Renal teams focus predominantly on renal replacement therapy and physical symptom management, rather than psychological issues, such as mental health, body image or self-esteem. This study aims to increase understanding ...

• Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data 

  Shields, Beverley M; Jones, Angus G.; Hattersley, Andrew T. (Elsevier, 2019-06)

  Research using data-driven cluster analysis has proposed five subgroups of diabetes with differences in diabetes progression and risk of complications. We aimed to compare the clinical utility of this subgroup-based approach ...

• Jejunal perforation and central retinal vein occlusion in a 55-year-old European man 

  Thomas, Amanda Louise; Summers, Lukes; Goodhand, James R.; Saunders, Sarah (BMJ, 2019-04-26)

• A specific CNOT1 mutation results in a novel syndrome of pancreatic agenesis and holoprosencephaly through impaired pancreatic and neurological development 

  De Franco, Elisa; Flanagan, Sarah E.; Ellard, Sian; Hattersley, Andrew T. (Cell Press, 2019-05)

  We report a recurrent CNOT1 de novo missense mutation, GenBank: NM_016284.4; c.1603C>T (p.Arg535Cys), resulting in a syndrome of pancreatic agenesis and abnormal forebrain development in three individuals and a similar ...

• Type 1 diabetes defined by severe insulin deficiency occurs after 30 years of age and is commonly treated as type 2 diabetes 

  Weedon, Michael N.; Shields, Beverley; Oram, RIchard A.; McDonald, Timothy J.; Hattersley, Andrew T.; Jones, Angus G. (Springer, 2019-07)

  Late-onset type 1 diabetes can be difficult to identify. Measurement of endogenous insulin secretion using C-peptide provides a gold standard classification of diabetes type in longstanding diabetes that closely relates ...

• Cystic fibrosis and insulin therapy: a reality check 

  Warren, Roderick (Wiley, 2019-04)

• Trisomy 21 is a cause of permanent neonatal diabetes that is autoimmune but not HLA associated 

  De Franco, Elisa; Ellard, Sian; Flanagan, Sarah E.; Patel, Kashyap; Hattersley, Andrew T. (American Diabetes Association, 2019-04)

  Identifying new causes of permanent neonatal diabetes (diagnosis <6 months; PNDM) provides important insights into β-cell biology. Patients with Down syndrome (DS) resulting from trisomy 21 are 4 times more likely to have ...

• Persistent C-peptide is associated with reduced hypoglycaemia but not HbA1c in adults with longstanding Type 1 diabetes: evidence for lack of intensive treatment in UK clinical practice? 

  McDonald, Timothy J.; Shields, Beverley; Knight, Bridget; Hattersley, Andrew T.; Jones, Angus G.; Oram, Richard (Wiley, 2019-04)

  Most people with Type 1 diabetes have low levels of persistent endogenous insulin production. The Diabetes Control and Complications Trial showed that close to diagnosis preserved endogenous insulin was associated with ...

• Up to date on phosphate management and phosphate binders 

  McAleer, Nick (Mark Allen Group, 2019-02)

  Although the cause of hyperphosphatemia remains the same, its management through dietary advice and medication is changing to keep up with the latest evidence. This article discusses some of the recent updates to the KDIGO ...

• Association between level of fecal calprotectin and progression of Crohn's Disease 

  Kennedy, Nicholas A. (Elsevier, 2019-02-14)

  Mucosal healing is associated with improved outcomes in patients with Crohn’s disease (CD), but assessment typically requires ileocolonoscopy. Calprotectin can be measured in fecal samples to determine luminal disease ...

• Sarcoidosis in the UK: insights from British Thoracic Society registry data 

  Lines, Sarah (BMJ, 2019-02)

  Introduction: The British Thoracic Society Sarcoidosis Registry allows physicians to record clinical data after gaining written consent from patients. The registry's aim is to phenotype sarcoidosis in the UK. Methods: ...

• The real world impact of adalimumab on quality of life and the physical and psychological effects of moderate-to-severe psoriasis: a UK prospective, multicenter, observational study 

  Downs, Anthony (Taylor & Francis, 2019-03)

  Psoriasis can adversely affect quality of life (QoL) and emotional well-being. In this UK prospective observational study we evaluated the 'real-world' impact of adalimumab on QoL and the physical/psychological effects of ...

• Reply to: Confouding factors affecting sRAGE as biomarker for COPD 

  Halpin, David (American Thoracic Society, 2019-03-19)

• Six-Month Results of Treatment-Blinded Medication Titration for Hypertension Control Following Randomization to Endovascular Ultrasound Renal Denervation or a Sham Procedure in the RADIANCE-HTN SOLO Trial 

  Sharp, Andrew (American Heart Association, 2019-03-17)

  The multicenter, international, randomized, blinded, sham-controlled RADIANCE-HTN SOLO trial demonstrated a 6.3 mmHg greater reduction in daytime ambulatory systolic blood pressure (BP) at 2 months by endovascular ultrasound ...

• Planning and providing acute stroke care in England: the effect of planning footprint size 

  James, Martin (Frontiers, 2019-02)

  Background: Guidelines in England recommend that hyperacute stroke units (HASUs) should have a minimum of 600 confirmed stroke admissions per year in order to sustain expert consultant-led services, and that travel time ...

• Naloxone prescribing: room for finesse 

  Gilham, James; Lloyd, Gavin (Mark Allen Group, 2019-03)

• Global strategy for the diagnosis, management, and prevention of Chronic Obstructive Lung Disease: the GOLD Science Committee Report 2019 

  Halpin, David M. (European Respiratory Society, 2019-05)

  Precision medicine is a patient-specific approach that integrates all relevant clinical, genetic and biological information in order to optimise the therapeutic benefit relative to the possibility of side-effects for each ...

• Time trends in prescribing of type 2 diabetes drugs, glycaemic response and risk factors: A retrospective analysis of primary care data, 2010-2017 

  Hattersley, Andrew; Shields, Beverley M.; Jones, Angus G (Wiley, 2019-03)

  Aim To describe population‐level time trends in prescribing patterns of type 2 diabetes therapy, and in short‐term clinical outcomes (glycated haemoglobin [HbA1c], weight, blood pressure, hypoglycaemia and treatment ...

• Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study 

  Kennedy, Nicholas A; Heap, Graham; Hamilton, Benjamin; Bewshea, Claire; Walker, Gareth; Thomas, Amanda; Nice, Rachel; Perry, Mandy; Hendy, Peter; Lin, Simeng; McDonald, Timothy; Goodhand, James; Ahmad, Tariq (Elsevier, 2019-05)

  Anti-TNF drugs are effective treatments for the management of Crohn's disease but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors that predict primary non-response at week 14 after ...

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