• Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study 

  Jones, A. G.; Hattersley, Andrew T.; McDonald, Timothy J. (HighWire, 2021-02)

  Objective: We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D). Research design and methods: A total of 732 recently diagnosed patients with T2D from the Innovative Medicines Initiative ...

• Sudden Unexpected Death in Epilepsy (SUDEP) and seizure safety: Modifiable and non-modifiable risk factors differences between primary and secondary care 

  Henley, W. E.; Shankar, R. (Elsevier Science, 2021-02)

  Introduction: The SUDEP and Seizure Safety Checklist ("Checklist") is a risk factors Checklist based around a person with epilepsy (PWE) demographics, seizure, physical, psychological, and lifestyle issues. The Checklist ...

• Evaluation of pregnancy outcomes in women with GCK-MODY 

  Colclough, Kevin (Wiley, 2021-06)

  Aims: To determine the fetal and maternal outcomes in pregnant women with Glucokinase-Maturity onset diabetes of the young (GCK-MODY). Methods: We studied the obstetric and perinatal outcomes in 99 pregnancies of 34 ...

• A Comparison of the Real-Life Clinical Effectiveness of the Leading Licensed ICS/LABA Combination Inhalers in the Treatment for COPD 

  Halpin, David M (Dove Medical Press, 2020-11-26)

  Introduction: The Fostair® 100/6 (BDP/FF) pressurized metered-dose inhaler, delivering an extrafine formulation, is licensed for asthma and COPD in the UK. However, its real-life effectiveness for COPD has not been evaluated. ...

• Patterns of Mitochondrial TSPO Binding in Cerebral Small Vessel Disease: An in vivo PET Study With Neuropathological Comparison 

  Ballard, Clive (Frontiers Media, 2020-10-16)

  Small vessel disease (SVD) is associated with cognitive impairment in older age and be implicated in vascular dementia. Post-mortem studies show proliferation of activated microglia in the affected white matter. However, ...

• Mild cognitive impairment: the Manchester consensus 

  Ballard, Clive (Silverchair, 2021-01-08)

  Given considerable variation in diagnostic and therapeutic practice, there is a need for national guidance on the use of neuroimaging, fluid biomarkers, cognitive testing, follow-up and diagnostic terminology in mild ...

• Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis 

  Jones, S. E.; Beaumont, Robin N.; Tyrrell, Jessica; Frayling, Timothy M.; Wood, A. R.; Weedon, M. N. (Silverchair, 2020-11-05)

  Background: It is established that Alzheimer's disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset ...

• Increased isoform-specific phosphodiesterase 4D expression is associated with pathology and cognitive impairment in Alzheimer's disease 

  Roubroeks, J.; Lunnon, Katie (Elsevier Science, 2021-01)

  Pharmacological phosphodiesterase 4D (PDE4D) inhibition shows therapeutic potential to restore memory function in Alzheimer's disease (AD), but will likely evoke adverse side effects. As PDE4D encodes multiple isoforms, ...

• Next-Generation RNA-Sequencing of Serum Small Extracellular Vesicles Discovers Potential Diagnostic Biomarkers for Dementia With Lewy Bodies 

  Ballard, Clive (Elsevier Science, 2021-06)

  Objective: There is an urgent clinical need for identifying blood-based diagnostic biomarkers for Dementia with Lewy Bodies (DLB). Transcriptomic studies have reported unique RNA changes in postmortem DLB brains. Small ...

• The feasibility of online video calling to engage patients with cystic fibrosis in exercise training 

  Tomlinson, O. W.; Shelley, James; Trott, Jayne; Bowhay, Ben; Chauhan, Rohan; Sheldon, Christopher David (Atypon, 2020-07)

  Introduction: Physical activity, including structured exercise, is an essential component in the management of cystic fibrosis. The use of telehealth such as video-calling may be a useful method for the delivery of exercise ...

• YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress 

  De Franco, Elisa; Wakeling, M. N.; Ellard, Sian; Hattersley, Andrew T.; Patel, Kashyap; Laver, T. W.; Johnson, M. B.; Flanagan, Sarah (American Society for Clinical Investigation, 2020-12-01)

  Neonatal diabetes is caused by single gene mutations reducing pancreatic β cell number or impairing β cell function. Understanding the genetic basis of rare diabetes subtypes highlights fundamental biological processes in ...

• Isoform-specific upregulation of FynT kinase expression is associated with tauopathy and glial activation in Alzheimer's disease and Lewy body dementias 

  Ballard, Clive (Wiley, 2021-03)

  Cumulative data suggest the involvement of Fyn tyrosine kinase in Alzheimer's disease (AD). Previously, our group has shown increased immunoreactivities of the FynT isoform in AD neocortex (with no change in the alternatively ...

• Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis 

  Boulanger, Carole (Nature Publishing Group, 2020-10-29)

  Female and male very elderly intensive patients (VIPs) might differ in characteristics and outcomes. We aimed to compare female versus male VIPs in a large, multinational collective of VIPs with regards to outcome and ...

• Full-thickness Skin Graft Fixation Techniques: A Review of the Literature 

  Xie, Fangyi (PubMed Central, 2020-07)

  Multiple techniques for skin graft fixation have been proposed, but the evidence underlying these techniques is unclear. This study aimed to review the literature for full-thickness graft fixation techniques. PubMed was ...

• Screening and Intervention to Prevent Falls and Fractures in Older People 

  Lamb, S. E.; Hulme, C; Sheridan, Ray (Atypon, 2020-11-05)

  Background: Community screening and therapeutic prevention strategies may reduce the incidence of falls in older people. The effects of these measures on the incidence of fractures, the use of health resources, and ...

• From GOLD 0 to Pre-COPD 

  Halpin, David M (Atypon, 2021-02-15)

• Validating the positivity thresholds of drug-tolerant anti-infliximab and anti-adalimumab antibody assays 

  Nice, Rachel; Chanchlani, Neil; Bewshea, Claire; Ahmad, Tariq; Goodhand, James R.; McDonald, Timothy J.; Perry, Mandy; Kennedy, Nicholas A. (Wiley, 2021-01)

  Background: When used proactively, drug-tolerant anti-tumour necrosis factor (TNF) antibody assays provide early opportunity to suppress immunogenicity. Aim: To validate positivity thresholds of IDKmonitor drug-tolerant ...

• Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy 

  Atkins, J. L.; Pilling, L. C.; Masoli, Jane A.; Melzer, David (Silverchair, 2020-11-24)

  Importance: Hereditary hemochromatosis is predominantly caused by the HFE p.C282Y homozygous pathogenic variant. Liver carcinoma and mortality risks are increased in individuals with clinically diagnosed hereditary ...

• Effects of exenatide on microvascular reactivity in patients with type 2 diabetes and coronary artery disease: A randomized controlled study 

  Shore, Angela (Wiley, 2021-02)

  This article is available to RD&E staff via NHS OpenAthens. Click on the Publisher URL, and log in with NHS OpenAthens if prompted.

• Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study 

  Hattersley, Andrew T.; McDonald, Timothy J. (Springer, 2021-01)

  Unfortunately, 'Present address' was omitted from one of the addresses provided for Mark I. McCarthy (#26).

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