Medical Services
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This community includes the research outputs from the Medical Services division which includes services such as: Cardiology, Diabetes, the Emergency Department, Neurology and Stroke. Browse the list of individual departments below.
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Clinical examination remains crucial to the correct diagnosis: a case of severe peripheral oedema referred for investigation of heart failure
(BMJ, 2019-08)Hepatocellular carcinoma (HCC) uncommonly metastasises to the heart. We present a case of new onset bilateral leg swelling and suspected right heart failure in a previously fit and healthy man, which on further investigation ... -
Algorithmic versus expert human interpretation of instantaneous wave-free ratio coronary pressure-wire pull back data
(Elsevier, 2019-07)The aim of this study was to investigate whether algorithmic interpretation (AI) of instantaneous wave-free ratio (iFR) pressure-wire pull back data would be noninferior to expert human interpretation. -
Comparison of major adverse cardiac events between instantaneous wave-free ratio and fractional flow reserve-guided strategy in patients with or without type 2 diabetes: a secondary analysis of a randomized clinical trial
(JAMA, 2019-07)Invasive physiologic indices such as fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are used in clinical practice. Nevertheless, comparative prognostic outcomes of iFR-guided and FFR-guided treatment ... -
The role of molecular genetics in the clinical management of sporadic medullary thyroid carcinoma: A systematic review
(Wiley, 2019-12)The significant variation in the clinical behaviour of sporadic medullary thyroid carcinoma (sMTC) causes uncertainty when planning the management of these patients. Several tumour genetic and epigenetic markers have been ... -
Joint UK societies' 2019 consensus statement on renal denervation
(BMJ, 2019-10)Improved and durable control of hypertension is a global priority for healthcare providers and policymakers. There are several lifestyle measures that are proven to result in improved blood pressure (BP) control. Moreover, ... -
Type 1 diabetes genetic risk score discriminates between monogenic and Type 1 diabetes in children diagnosed at the age of <5 years in the Iranian population
(Wiley, 2019-07)AIM To examine the extent to which discriminatory testing using antibodies and Type 1 diabetes genetic risk score, validated in European populations, is applicable in a non-European population. METHODS: We recruited 127 ... -
Cathepsin L-induced galectin-1 may act as a proangiogenic factor in the metastasis of high-grade serous carcinoma
(Biomed Central, 2019-07)New treatment options for metastasised high-grade serous carcinoma (HGSC) are urgently needed. HGSC frequently metastasises to the omentum, inducing angiogenesis in the local omental microvasculature to facilitate tumour ... -
Factors associated with depression in people with inflammatory bowel disease: The relationship between active disease and biases in neurocognitive processing
(Wiley, 2019-08)Depression is common among people with inflammatory bowel disease (IBD), though the causes remain unclear. We conducted a cross-sectional study to investigate the role of emotional processing biases in contributing to ... -
Renal sympathetic denervation for treatment of hypertension: where are we now in 2019?
(Wolters Kluwer, 2019-09)Although sound physiological principles and surgical precedent underpin renal denervation as a therapy for treatment resistant hypertension, and early clinical studies had produced encouraging results, the first sham-controlled ... -
Association of maternal circulating 25(OH)D and calcium with birth weight: A mendelian randomisation analysis
(PLoS, 2019-06)Systematic reviews of randomised controlled trials (RCTs) have suggested that maternal vitamin D (25[OH]D) and calcium supplementation increase birth weight. However, limitations of many trials were highlighted in the ... -
Improving patient care in monogenic diabetes through research and education
(Wiley, 2019-05)The 2019 Arnold Bloom lecture reviewed the progress in monogenic diabetes since the start of the service in Exeter in 1995 to present day. The impact of a correct molecular genetic diagnosis has been profound for many ... -
Remission of membranous nephropathy after treatment of localised prostate cancer
(Karger, 2019-06)Membranous nephropathy is a cause of the nephrotic syndrome in adults; it can be a primary or secondary process. Secondary causes include solid organ and lymphoid malignancies. Prostate cancer has been reported as the ... -
Drug toxicity: personalising IBD therapeutics - the use of genetic biomarkers to reduce drug toxicity
(Springer, 2019-05)Adverse drug reactions (ADRs) result in morbidity and mortality as well as placing a significant financial burden on health-care resources. In Europe and North America, they are responsible for approximately 6% of all ... -
A blood-based prognostic biomarker in IBD
(BMJ, 2019-08)We have previously described a prognostic transcriptional signature in CD8 T cells that separates patients with IBD into two phenotypically distinct subgroups, termed IBD1 and IBD2. Here we sought to develop a blood-based ... -
Transient neonatal diabetes: an etiologic clue for the adult diabetologist
(Elsevier, 2019-05) -
In response to reduced acetazolamide dose for AMS by McIntosh et al
(Elsevier, 2019-09) -
Exercise-based cardiac rehabilitation for stable angina: systematic review and meta-analysis
(BMJ, 2019-06)A systematic review was undertaken to assess the effects of exercise-based cardiac rehabilitation (CR) for patients with stable angina.
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