• Diffuse encephalitic toxoplasmosis in HIV. 

  Pearce, Jasmine; Sheridan, Ray; Shaw, Johnathan; Senior, Thomas (BMJ, 2021-03-18)

  This case demonstrates an atypical radiological presentation of cerebral toxoplasmosis in a 62-year-old HIV-positive patient. The diagnosis is discussed alongside MRI imaging, laboratory results and treatment. Central ...

• Editorial: missed opportunities to detect colorectal cancer in inflammatory bowel disease-getting to the root. Authors' reply 

  Chee, Desmond; Kennedy, Nicholas A.; Goodhand, James R.; Ahmad, Tariq (Wiley, 2021-01-01)

• P129 IBD care in the UK: A comprehensive, novel service assessment with feedback from 10,222 patients and 166 NHS organisations to inform a vision for quality improvement 

  Wakeman, R; Ainley, R; Arnott, I D; Barrett, K J; Bell, G; Berry, S; Bhatnagar, G; Blackwell, J; Bloom, S; Bramwell, C; Brookes, M J; Burman, A; Cairnes, V; Crook, K; Dobson, L; Epstein, J; Faiz, O; Feakins, R; Fletcher, M; Garrick, V; Glatter, J; Hawthorne, A B; Keetarut, K; Lamb, C A; Lee, M; Meade, U; Muhammed, R; Murdock, A; Nevill, A M; Parekh, A; Rochford, A; Rowse, G; Sagar, P; St.Clair-Jones, A; Segal, J; Selinger, C P; Sleet, S; Taylor, S; Winsor, G; Younge, L (Oxford University Press, 2021-05-01)

  The IBD Benchmarking Tool, comprising an online Service Self-Assessment and Patient Survey, has provided a unique and comprehensive picture of Inflammatory Bowel Disease (IBD) care across the UK. The aim was to evaluate ...

• Optimisation Verification for a Millimetre-Scale Vibro-Impact Capsule System 

  Liu, Yang; Chávez, Joseph; Zhang, Jiajia; Tian, Jiyuan; Guo, Bingyong; Prasad, Shyam (#N/A, 2021-02-18)

  A self-propelled capsule endoscope moving inside patient's gut is a promising means of minimising patient's painful investigation and improve the diagnostic efficiency. This paper presents the study of a millimetre-scale ...

• P135 Maintenance of antifibrotic treatment for IPF in the South West Peninsula & Exeter ILD service – a real world study 

  Lines, S. J.; Nancarrow, T.; Romero, B. Carbillido; Mandizha, J.; Gibbons, M. A. (BMJ, 2021-02-01)

  IPF is a life-limiting condition with an average prognosis of three years from diagnosis. The two anti-fibrotic therapies that are available, Pirfenidone and Nintedanib, can help slow progression of fibrosis and prolong ...

• Measuring coping in people with amyotrophic lateral sclerosis using the Coping Index-ALS: A patient derived, Rasch compliant scale 

  Young, C. A.; McDermott, C. J.; Williams, T. L.; Ealing, J.; Majeed, T.; Al-Chalabi, A.; Dick, D. J.; Talbot, K.; Harrower, T.; Pinto, A.; Hanemann, C. O.; Burke, G.; Roberts, R.; Mills, R. J.; Tennant, A. (Elsevier, 2021-02-15)

  OBJECTIVE: The progressively disabling and terminal nature of ALS/MND imposes major coping demands on patients. We wished to improve the psychometric properties of our previously published MND-Coping Scale, so that parametric ...

• Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress 

  Montaser, Hossam; Patel, Kashyap A.; Balboa, Diego; Ibrahim, Hazem; Lithovius, Väinö; Näätänen, Anna; Chandra, Vikash; Demir, Korcan; Acar, Sezer; Ben-Omran, Tawfeg; Colclough, Kevin; Locke, Jonathan M.; Wakeling, Matthew; Lindahl, Maria; Hattersley, Andrew T.; Saarimäki-Vire, Jonna; Otonkoski, Timo (American Diabetes Association, 2021-04-01)

  Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-resident protein that plays a crucial role in attenuating ER stress responses. Although MANF is indispensable for the survival and ...

• Molecular genetic dissection of inflammatory linear verrucous epidermal naevus leads to successful targeted therapy 

  Riachi, Melissa; Polubothu, Satyamaanasa; Stadnik, Paulina; Connor, Hughes; Barberan Martin, Sara; Charman, Carolyn R.; Cheng, Iek Leng; Gholam, Karolina; Ogunbiyi, Olumide; Paige, David G.; Sebire, Neil J.; Pittman, Alan; Di, Wei-Li; Kinsler, Veronica A. (Elsevier, 2021-06-08)

• Monogenic diabetes: a gateway to precision medicine in diabetes 

  Zhang, Haichen; Colclough, Kevin; Gloyn, Anna L.; Pollin, Toni I. (American Society for Clinical Investigation, 2021-02-01)

  Monogenic diabetes refers to diabetes mellitus (DM) caused by a mutation in a single gene and accounts for approximately 1%-5% of diabetes. Correct diagnosis is clinically critical for certain types of monogenic diabetes, ...

• Integrating a treat to target approach into clinical practice in 2020 

  Kennedy, Nicholas A. (Wiley, 2021-04-01)

• Hemicrania continua associated with an unruptured anterior communicating artery aneurysm: first case report 

  Imam, Ibrahim (BMC, 2021-03-08)

• Feasibility of cardiopulmonary exercise testing in interstitial lung disease: the PETFIB study 

  Tomlinson, Owen; Duckworth, Anna; Markham, Laura; Wollerton, Rebecca; Knight, Bridget; Spiers, Alexander; Gibbons, Michael; Williams, Craig; Scotton, Chris (BMJ, 2021-04-01)

  INTRODUCTION: Cardiopulmonary exercise testing (CPET) provides a series of biomarkers, such as peak oxygen uptake, which could assess the development of disease status in interstitial lung disease (ILD). However, despite ...

• Fifteen-minute consultation: Practical use of continuous glucose monitoring 

  Soni, Astha; Wright, Neil; Agwu, Juliana Chizo; Drew, Josephine; Kershaw, Melanie; Moudiotis, Christopher; Regan, Fiona; Williams, Eleri; Timmis, Alison; Ng, Sze May (BMJ, 2021-05-07)

  Type 1 diabetes is a self-managed condition. Regular monitoring of blood glucose (BG) levels has been the cornerstone of diabetes management. Finger prick BG testing traditionally has been the standard method employed. ...

• Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile 

  Heald, Adrian H.; Martin, Susan; Fachim, Helene; Green, Harry D.; Young, Katherine G.; Malipatil, Nagaraj; Siddals, Kirk; Cortes, Gabriela; Tyrrell, Jessica; Wood, Andrew R.; Beaumont, Robin N.; Frayling, Timothy M.; Donn, Rachelle; Narayanan, Ram Prakash; Ollier, William; Gibson, Martin; Yaghootkar, Hanieh (Wiley, 2021-01-27)

  AIMS: Change in weight, HbA(1c) , lipids, blood pressure and cardiometabolic events over time is variable in individuals with type 2 diabetes. We hypothesised that people with a genetic predisposition to a more favourable ...

• Genotype and Phenotype Heterogeneity in Neonatal Diabetes: A Single Centre Experience in Turkey 

  Denkboy Öngen, Yasemin; Eren, Erdal; Demirbaş, Özgecan; Sobu, Elif; Ellard, Sian; De Franco, Elisa; Tarım, Ömer (Galenos, 2021-02-26)

  OBJECTIVE: Neonatal diabetes mellitus (NDM) may be transient or permanent, and the majority is caused by genetic mutations. Early diagnosis is essential to select the patients who will respond to oral treatment. In this ...

• Finite Element Modelling of a Vibro-Impact Capsule Moving in the Small Intestine 

  Tian, Jiyuan; Liu, Yang; Guo, Bingyong; Prasad, Shyam (#N/A, 2021-02-18)

  The present work aims to develop a realistic finite element (FE) model to depict the nonlinear dynamics of a vibro-impact capsule moving in the small intestine for capsule endoscopy. The FE model considers both the nonlinear ...

• Effectiveness of Bariatric Surgery vs Community Weight Management Intervention for the Treatment of Idiopathic Intracranial Hypertension: A Randomized Clinical Trial 

  Mollan, Susan P.; Mitchell, James L.; Ottridge, Ryan S.; Aguiar, Magda; Yiangou, Andreas; Alimajstorovic, Zerin; Cartwright, David M.; Grech, Olivia; Lavery, Gareth G.; Westgate, Connar S. J.; Vijay, Vivek; Scotton, William; Wakerley, Ben R.; Matthews, Tim D.; Ansons, Alec; Hickman, Simon J.; Benzimra, James; Rick, Caroline; Singhal, Rishi; Tahrani, Abd A.; Brock, Kristian; Frew, Emma; Sinclair, Alexandra J. (JAMA, 2021-06-01)

  IMPORTANCE: Idiopathic intracranial hypertension (IIH) causes headaches, vision loss, and reduced quality of life. Sustained weight loss among patients with IIH is necessary to modify the disease and prevent relapse. ...

• DOP35 Ambulatory care management of 70 patients with Acute Severe Ulcerative Colitis in comparison to 700 inpatients: Insights from a multicentre UK cohort study 

  Patel, K V; Segal, J; Sebastian, S; Subramanian, S; Conley, T; Gonzalez, H; Kent, A; Saifuddin, A; Hicks, L; Mehta, S; Bhala, N; Brookes, M; Lamb, C; Kennedy, N; Walker, G; PROTECT ASUC collaborators (Oxford University Press, 2021-05-01)

  Acute severe ulcerative colitis (ASUC) traditionally requires inpatient hospital management for intravenous therapies and/or colectomy. Patients with ASUC can deteriorate rapidly and hence require close monitoring of vital ...

• Downstream testing after CT coronary angiography: time for a rethink? 

  Morgan-Hughes, Gareth; Williams, Michelle Claire; Loudon, Margaret; Roobottom, Carl A.; Veitch, Alice; Van Lingen, Robin; Holloway, Ben; Bellenger, Nicholas; Schmitt, Matthias; Bull, Russel (BMJ, 2021-02-01)

  OBJECTIVE: We surveyed UK practice and compliance with the National Institute for Health and Care Excellence (NICE) 'recent-onset chest pain' guidance (Clinical Guideline 95, 2016) as a service quality initiative. We aimed ...

• EAES rapid guideline: appendicitis in the elderly 

  Antoniou, Stavros A.; Mavridis, Dimitris; Kontouli, Katerina Maria; Drakopoulos, Vasileios; Gorter-Stam, Marguerite; Eriksson, Sture; Leone, Marc; Pérez-Bocanegra, Maria Carmen; Smart, Neil J.; Milone, Marco; Carrano, Francesco Maria; Antoniou, George A.; Vandvik, Per Olav (Springer, 2021-07-01)

  BACKGROUND: There is a lack of trustworthy evidence-informed guidelines on the diagnosis and management of acute appendicitis in elderly patients. METHODS: We developed a rapid guideline in accordance with GRADE and AGREE ...

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