• Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection 

  Morgan, Noel; Richardson, S. J. (Multidisciplinary Digital Publishing Institue, 2020-09-15)

  Enteroviruses (EVs) have long been implicated in the pathogenesis of type 1 diabetes (T1D), and accumulating evidence has associated virus-induced autoimmunity with the loss of pancreatic beta cells in T1D. Inflammatory ...

• Response to Comment on Misra et al. Homozygous Hypomorphic HNF1A Alleles Are a Novel Cause of Young-Onset Diabetes and Result in Sulfonylurea-Sensitive Diabetes. Diabetes Care 2020;43:909-912 

  Caswell, Richard; Colclough, Kevin; Ellard, Sian (HighWire, 2020-10)

• Unsupervised Clustering of Missense Variants in HNF1A Using Multidimensional Functional Data Aids Clinical Interpretation 

  Colclough, Kevin; Ellard, Sian (Elsevier Science, 2020-10-01)

  Exome sequencing in diabetes presents a diagnostic challenge because depending on frequency, functional impact, and genomic and environmental contexts, HNF1A variants can cause maturity-onset diabetes of the young (MODY), ...

• Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor for 24 Weeks or Longer in People with Cystic Fibrosis and One or More F508del Alleles: Interim Results of an Open-Label Phase 3 Clinical Trial 

  Withers, Nicholas J. (Atypon, 2021-02-01)

• Clinical Characteristics and Long-term Follow-up of Patients with Diabetes Due To PTF1A Enhancer Mutations 

  Flanagan, Sarah; Hattersley, Andrew T.; De Franco, Elisa (Silverchair Information Systems, 2020-12-01)

  Context: Biallelic mutations in the PTF1A enhancer are the commonest cause of isolated pancreatic agenesis. These patients do not have severe neurological features associated with loss-of-function PTF1A mutations. Their ...

• Massive pulmonary embolism in patients with extreme bleeding risk: a case series on the successful use of ultrasound-assisted, catheter directed thrombolysis in a district general hospital 

  He, Jingzhou; Clayton, B.; Gibbons, Michael; Watkinson, Anthony (Springer, 2020-09-04)

  Massive pulmonary embolism (PE), characterised by profound arterial hypotension, is a life-threatening emergency with a 90-day mortality of over 50%. Systemic thrombolysis can significantly reduce the risk of death or ...

• Editorial: palliative long-term abdominal drains in refractory ascites-a step in the right direction, but not the complete solution 

  Hudson, Ben (Wiley, 2020-08)

• Percutaneous microwave ablation of renal masses in a UK cohort 

  John, Joseph; Anderson, Moria; Dutton, Thomas; Stott, Mark A.; Crundwell, Malcom; Gemmell, Andrew; Spiers, Alexander; Campain, Nicholas J (Wiley, 2020-09-01)

  Objectives: To report a tertiary referral centre's experience of microwave ablation (MWA) for suspected renal cell carcinoma (RCC), describing complications and oncological outcomes. Patients and methods: Consecutive ...

• Evaluating enhanced recovery after surgery: time to cover new ground and discover the missing patient voice 

  Nunns, M.; John, Joseph; McGrath, John S; Briscoe, S.; Thompson Coon, J.; Lovegrove, Chris; Thomas, David; Anderson, R. (BioMed Central, 2020-09-14)

  Multicomponent peri-operative interventions offer to accelerate patient recovery and improve cost-effectiveness. The recent National Institute of Health Research-commissioned evidence synthesis review by Nunns et al. ...

• Scrofula associated with a patient receiving adalimumab therapy for Crohn disease 

  Hunt, William T.; Wheeler, J.; Kennedy, Nicholas A.; Burden, T.; McGrath, Emily J. (Wiley, 2021-01)

• The clinical consequences of heterogeneity within and between different diabetes types 

  Oram, Richard; Weedon, M. (Springer, 2020-10)

  Advances in molecular methods and the ability to share large population-based datasets are uncovering heterogeneity within diabetes types, and some commonalities between types. Within type 1 diabetes, endotypes have been ...

• Organisational changes and challenges for inflammatory bowel disease services in the UK during the COVID-19 pandemic 

  Kennedy, Nicholas A. (BMJ, 2020-06-16)

  Objective: To determine the challenges in diagnosis, monitoring, support provision in the management of inflammatory bowel disease (IBD) patients and explore the adaptations of IBD services. Methods: Internet-based ...

• An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene 

  Roubroeks, J.; Smith, Adam R.; Smith, R. G.; Pishva, Ehsan; Hannon, Eilis; Mill, Jonathan; Lunnon, Katie (Elsevier Science, 2020-11)

  A growing number of epigenome-wide association studies have demonstrated a role for DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral biomarker potential, we have examined DNA ...

• Dementia prevention, intervention, and care: 2020 report of the Lancet Commission 

  Ballard, Clive (Elsevier Science, 2020-08-08)

• Functional cognitive disorder: dementia's blind spot 

  Ballard, Clive (Oxford University Press, 2020-10-01)

  An increasing proportion of cognitive difficulties are recognized to have a functional cause, the chief clinical indicator of which is internal inconsistency. When these symptoms are impairing or distressing, and not better ...

• Precision Medicine in Type 2 Diabetes: Using Individualized Prediction Models to Optimize Selection of Treatment 

  Dennis, J. M. (HighWire, 2020-10)

  Despite the known heterogeneity of type 2 diabetes and variable response to glucose lowering medications, current evidence on optimal treatment is predominantly based on average effects in clinical trials rather than ...

• British Thoracic Society guideline for the use of long-term macrolides in adults with respiratory disease 

  Mitchelmore, Philip J. (BMJ, 2020-05)

• Risk of Anemia With Metformin Use in Type 2 Diabetes: A MASTERMIND Study 

  Dennis, J. M.; Hattersley, Andrew T. (HighWire, 2020-10)

  Objective: To evaluate the association between metformin use and anemia risk in type 2 diabetes, and the time-course for this, in a randomized controlled trial (RCT) and real-world population data. Research design and ...

• Real-world adherence, persistence, and in-class switching during use of dipeptidyl peptidase-4 inhibitors: a systematic review and meta-analysis involving 594,138 patients with type 2 diabetes 

  McGovern, Andrew (Springer, 2021-01)

  Aims: Medication adherence and persistence are important determinants of treatment success in type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis evaluated the real-world adherence, persistence, and ...

• Physical activity assessment by accelerometry in people with heart failure 

  Gandhi, Manish; Taylor, R. S.; Dalal, H. M. (BioMed Central, 2020-08-12)

  Background: International guidelines for physical activity recommend at least 150 min per week of moderate-to-vigorous physical activity (MVPA) for adults, including those with cardiac disease. There is yet to be consensus ...

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