Specialist Services: Recent submissions
Now showing items 1-20 of 720
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Republished: Immune checkpoint inhibitor induced large vessel vasculitis
(HighWire, 2021-02) -
Understanding surgical antimicrobial prescribing behaviour in the hospital setting: a systematic review and meta-ethnography protocol
(BioMed Central, 2020-10-10)Background: Surgical specialities use extensive amounts of antimicrobials, and misuse has been widely reported, making them a key target for antimicrobial stewardship initiatives. Interventions informed by, and tailored ... -
Interventions to improve the mental health of children and young people with long-term physical conditions: linked evidence syntheses
(NIHR Journals Library, 2019-05)Background: Although mental health difficulties can severely complicate the lives of children and young people (CYP) with long-term physical conditions (LTCs), there is a lack of evidence about the effectiveness of ... -
Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial
(Elsevier Science, 2020-10)Background: Circulating tumour DNA (ctDNA) testing might provide a current assessment of the genomic profile of advanced cancer, without the need to repeat tumour biopsy. We aimed to assess the accuracy of ctDNA testing ... -
Geometric semi-automatic analysis of radiographs of Colles' fractures
(Public Library of Science, 2020-09-14)Fractures of the wrist are common in Emergency Departments, where some patients are treated with a procedure called Manipulation under Anaesthesia. In some cases, this procedure is unsuccessful and patients need to revisit ... -
The Management of Symptomatic Lumbar Disc Herniation in Pregnancy: A Systematic Review
(Atypon, 2020-10)Study design: Systematic review. Objectives: Lumbar disc herniation (LDH) has been reported to affect 1 in 10 000 pregnant women. There is limited evidence available regarding the optimal management of LDH in pregnant ... -
Massive pulmonary embolism in patients with extreme bleeding risk: a case series on the successful use of ultrasound-assisted, catheter directed thrombolysis in a district general hospital
(Springer, 2020-09-04)Massive pulmonary embolism (PE), characterised by profound arterial hypotension, is a life-threatening emergency with a 90-day mortality of over 50%. Systemic thrombolysis can significantly reduce the risk of death or ... -
Publisher Correction: The National Lung Matrix Trial of personalized therapy in lung cancer
(Nature Publishing Group, 2020-09)An amendment to this paper has been published and can be accessed via a link at the top of the paper. -
Are children with unrecognised psychiatric disorders being excluded from school? A secondary analysis of the British Child and Adolescent Mental Health Surveys 2004 and 2007
(Cambridge University Press, 2019-11)Background: There is limited research that explores the association between exclusion from school and mental health, but it seems intuitively plausible that the recognition of mental difficulties by key teachers and parents ... -
Guidelines on the use of irradiated blood components
(Wiley, 2020-12) -
Pathogenic germline variants in patients with features of hereditary renal cell carcinoma: Evidence for further locus heterogeneity
(Wiley, 2021-01)Inherited renal cell carcinoma (RCC) is associated with multiple familial cancer syndromes but most individuals with features of non-syndromic inherited RCC do not harbor variants in the most commonly tested renal cancer ... -
Challenging infections in pregnancy
(PubMed Central, 2020-09)Maternal sepsis is "a life-threatening condition defined as organ dysfunction resulting from infection during pregnancy, childbirth, post-abortion, or postpartum period." (World Health Organisation, 2017). Serious infection ... -
Robotic Management of Fibroids: Discussion of Use, Criteria and Advantages
(Acta Medica, 2020)Fibroids are the most common benign tumors affecting fertility and quality of life. Different methods either definitive or fertility sparing are used for their management by using open, laparoscopic and robotic techniques. ... -
HCV infection and the risk of head and neck cancer: A meta-analysis
(Elsevier Science, 2020-06-26)Recent evidence has consistently suggested a role for HCV in the etiology of head and neck squamous cell carcinoma (HNSCC), but the conclusions of these studies have often been limited by small sample size. Therefore, a ... -
The National Lung Matrix Trial of personalized therapy in lung cancer
(Nature Publishing Group, 2020-07)The majority of targeted therapies for non-small-cell lung cancer (NSCLC) are directed against oncogenic drivers that are more prevalent in patients with light exposure to tobacco smoke1-3. As this group represents around ... -
Ten-Year Results of FAST: A Randomized Controlled Trial of 5-Fraction Whole-Breast Radiotherapy for Early Breast Cancer
(Atypon, 2020-10-01)Purpose: Previous studies of hypofractionated adjuvant whole-breast radiotherapy for early breast cancer established a 15- or 16-fraction (fr) regimen as standard. The FAST Trial (CRUKE/04/015) evaluated normal tissue ... -
A Novel HNF4A Mutation Causing Three Phenotypic Forms of Glucose Dysregulation in a Family
(Frontiers Media SA, 2020-06-26)Maturity-onset diabetes of the young (MODY) classically describes dominantly inherited forms of monogenic diabetes diagnosed before 25 years of age due to pancreatic β-cell dysfunction. In contrast, mutations in certain ... -
Cerebral arteriopathy associated with heterozygous variants in the casitas B-lineage lymphoma gene
(Wolters Kluwer Health, Inc., 2020-06-10)Objective: To report a series of patients with cerebral arteriopathy associated with heterozygous variants in the casitas B-lineage lymphoma (CBL) gene and examine the functional role of the identified mutant Cbl protein. ... -
British Gynaecological Cancer Society (BGCS) vulval cancer guidelines: Recommendations for practice
(Elsevier Science, 2020-09)The purpose of this guideline is to collate evidence and propose evidence-based guidelines for the diagnosis and management of adult patients with vulva carcinoma treated in the UK. Malignant melanoma may present via similar ...