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Adverse events in faecal microbiota transplant: a review of the literature.
(Elsevier, 2015-12-15)Faecal microbiota transplant (FMT) is the infusion of donor faeces into the gut with the aim of improving microbial diversity. The procedure has gained significant interest recently in the treatment of recurrent Clostridium ... -
Pitfalls of haplotype phasing from amplicon-based long-read sequencing.
(Nature, 2016-02-17)The long-read sequencers from Pacific Bioscience (PacBio) and Oxford Nanopore Technologies (ONT) offer the opportunity to phase mutations multiple kilobases apart directly from sequencing reads. In this study, we used ... -
HNF1B Genetic Testing In a Turkish Cypriot Population with a High Incidence of Familial Kidney Disease
(OMICS International Journals, 2016-02-19) -
Glycosylation is an androgen-regulated process essential for prostate cancer cell viability
(Elsevier, 2016-04-20)Steroid androgen hormones play a key role in the progression and treatment of prostate cancer, with androgen deprivation therapy being the first-line treatment used to control cancer growth. Here we apply a novel search ... -
Paediatric procedural sedation using ketamine in a UK emergency department: a 7 year review of practice.
(Oxford Journals, 2016-02-17)Ketamine is growing in popularity for procedural sedation in the paediatric population, yet safety concerns remain. We performed a retrospective review of practice and outcomes of paediatric ketamine sedation using the ... -
Detection of C-Peptide in Urine as a Measure of Ongoing Beta Cell Function.
(Springer, 2016-04-16)C-peptide is a protein secreted by the pancreatic beta cells in equimolar quantities with insulin, following the cleavage of proinsulin into insulin. Measurement of C-peptide is used as a surrogate marker of endogenous ... -
Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial.
(Elsevier, 2015-12-21)Long-term hormone therapy has been the standard of care for advanced prostate cancer since the 1940s. STAMPEDE is a randomised controlled trial using a multiarm, multistage platform design. It recruits men with high-risk, ... -
Developing a vascular access team
(Mark Allen Group, 2016-02) -
Improving weekend handover between junior doctors on medical and surgical wards.
(BMJ, 2014-01-03)Poor weekend handover has been implicated as one of the causes of observed higher mortality rates at weekends in UK hospitals. In a large teaching hospital we, a group of junior doctors, set about improving the quality and ...