• Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial 

  Stephens, Peter (Elsevier Science, 2020-10)

  Background: Circulating tumour DNA (ctDNA) testing might provide a current assessment of the genomic profile of advanced cancer, without the need to repeat tumour biopsy. We aimed to assess the accuracy of ctDNA testing ...

• Geometric semi-automatic analysis of radiographs of Colles' fractures 

  Appelboam, Andrew; Knapp, Karen (Public Library of Science, 2020-09-14)

  Fractures of the wrist are common in Emergency Departments, where some patients are treated with a procedure called Manipulation under Anaesthesia. In some cases, this procedure is unsuccessful and patients need to revisit ...

• The Management of Symptomatic Lumbar Disc Herniation in Pregnancy: A Systematic Review 

  Stokes, Oliver M. (Atypon, 2020-10)

  Study design: Systematic review. Objectives: Lumbar disc herniation (LDH) has been reported to affect 1 in 10 000 pregnant women. There is limited evidence available regarding the optimal management of LDH in pregnant ...

• Massive pulmonary embolism in patients with extreme bleeding risk: a case series on the successful use of ultrasound-assisted, catheter directed thrombolysis in a district general hospital 

  He, Jingzhou; Clayton, B.; Gibbons, Michael; Watkinson, Anthony (Springer, 2020-09-04)

  Massive pulmonary embolism (PE), characterised by profound arterial hypotension, is a life-threatening emergency with a 90-day mortality of over 50%. Systemic thrombolysis can significantly reduce the risk of death or ...

• Publisher Correction: The National Lung Matrix Trial of personalized therapy in lung cancer 

  Toy, Elizabeth (Nature Publishing Group, 2020-09)

  An amendment to this paper has been published and can be accessed via a link at the top of the paper.

• Are children with unrecognised psychiatric disorders being excluded from school? A secondary analysis of the British Child and Adolescent Mental Health Surveys 2004 and 2007 

  Logan, Stuart (Cambridge University Press, 2019-11)

  Background: There is limited research that explores the association between exclusion from school and mental health, but it seems intuitively plausible that the recognition of mental difficulties by key teachers and parents ...

• Guidelines on the use of irradiated blood components 

  Kerr, Paul (Wiley, 2020-12)

• Pathogenic germline variants in patients with features of hereditary renal cell carcinoma: Evidence for further locus heterogeneity 

  Castle, Bruce; Sansbury, Francis H (Wiley, 2021-01)

  Inherited renal cell carcinoma (RCC) is associated with multiple familial cancer syndromes but most individuals with features of non-syndromic inherited RCC do not harbor variants in the most commonly tested renal cancer ...

• Challenging infections in pregnancy 

  Morgan, Marina (PubMed Central, 2020-09)

  Maternal sepsis is "a life-threatening condition defined as organ dysfunction resulting from infection during pregnancy, childbirth, post-abortion, or postpartum period." (World Health Organisation, 2017). Serious infection ...

• Robotic Management of Fibroids: Discussion of Use, Criteria and Advantages 

  Gkegkes, Ioannis D. (Acta Medica, 2020)

  Fibroids are the most common benign tumors affecting fertility and quality of life. Different methods either definitive or fertility sparing are used for their management by using open, laparoscopic and robotic techniques. ...

• The Impact of Treatment Crossover and Prostate-specific Antigen Flare with Enzalutamide and Abiraterone in Metastatic Castrate Resistant Prostate Cancer 

  Norris, T. (Elsevier Science, 2021-01)

• HCV infection and the risk of head and neck cancer: A meta-analysis 

  Fussey, Jonathan (Elsevier Science, 2020-06-26)

  Recent evidence has consistently suggested a role for HCV in the etiology of head and neck squamous cell carcinoma (HNSCC), but the conclusions of these studies have often been limited by small sample size. Therefore, a ...

• The National Lung Matrix Trial of personalized therapy in lung cancer 

  Toy, Elizabeth (Nature Publishing Group, 2020-07)

  The majority of targeted therapies for non-small-cell lung cancer (NSCLC) are directed against oncogenic drivers that are more prevalent in patients with light exposure to tobacco smoke1-3. As this group represents around ...

• Ten-Year Results of FAST: A Randomized Controlled Trial of 5-Fraction Whole-Breast Radiotherapy for Early Breast Cancer 

  Goodman, Andrew (Atypon, 2020-10-01)

  Purpose: Previous studies of hypofractionated adjuvant whole-breast radiotherapy for early breast cancer established a 15- or 16-fraction (fr) regimen as standard. The FAST Trial (CRUKE/04/015) evaluated normal tissue ...

• A Novel HNF4A Mutation Causing Three Phenotypic Forms of Glucose Dysregulation in a Family 

  Flanagan, Sarah (Frontiers Media SA, 2020-06-26)

  Maturity-onset diabetes of the young (MODY) classically describes dominantly inherited forms of monogenic diabetes diagnosed before 25 years of age due to pancreatic β-cell dysfunction. In contrast, mutations in certain ...

• Cerebral arteriopathy associated with heterozygous variants in the casitas B-lineage lymphoma gene 

  Rankin, Julia (Wolters Kluwer Health, Inc., 2020-06-10)

  Objective: To report a series of patients with cerebral arteriopathy associated with heterozygous variants in the casitas B-lineage lymphoma (CBL) gene and examine the functional role of the identified mutant Cbl protein. ...

• British Gynaecological Cancer Society (BGCS) vulval cancer guidelines: Recommendations for practice 

  Edey, Katharine A. (Elsevier Science, 2020-09)

  The purpose of this guideline is to collate evidence and propose evidence-based guidelines for the diagnosis and management of adult patients with vulva carcinoma treated in the UK. Malignant melanoma may present via similar ...

• Inheritance of a paternal ABCC8 variant and maternal loss of heterozygosity at 11p15 retrospectively unmasks the etiology in a case of Congenital hyperinsulinism 

  Houghton, Jayne A. L. (Wiley, 2020-04-23)

  Advances in genomics and 18F-DOPA PET-CT imaging have transformed the management of infants with Congenital Hyperinsulinism. Preoperative diagnosis of focal hyperinsulinism permits limited pancreatectomy with improved ...

• Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants 

  Brewer, Carole (Nature Publishing Group, 2020-10)

  Purpose: We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and BRCA2 pathogenic variant carriers. Methods: ...

• Biallelic variants in PPP1R13L cause paediatric dilated cardiomyopathy 

  Robinson, H. K.; Mallin, L.; Mabin, David C.; Turner, Claire L.; Ellard, Sian (Wiley, 2020-10)

  Childhood dilated cardiomyopathy (DCM) is a leading cause of heart failure requiring cardiac transplantation and approximately 5% of cases result in sudden death. Knowledge of the underlying genetic cause can aid prognostication ...

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