2017 RD&E publications

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A summary list of all RD&E research outputs published or issued in 2017.


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Now showing 1 - 5 of 326
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    Variation in the provision and practice of implant-based breast reconstruction in the UK: Results from the iBRA national practice questionnaire.
    (Elsevier, 2017-10) Mylvaganam, S. [et al}; Breast Reconstruction Research Collaborative inc.; Anesti, Katerina
    The introduction of biological and synthetic meshes has revolutionised the practice of implant-based breast reconstruction (IBBR) but evidence for effectiveness is lacking. The iBRA (implant Breast Reconstruction evAluation) study is a national trainee-led project that aims to explore the practice and outcomes of IBBR to inform the design of a future trial. We report the results of the iBRA National Practice Questionnaire (NPQ) which aimed to comprehensively describe the provision and practice of IBBR across the UK.
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    Experiences of people with Parkinsonʼs disease and their views of physical activity interventions
    (LWW, 2017-11) Hunter, H.; Lovegrove, Chris; Haas, B.; Freeman, J.; Gunn, H.
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    Capturing real-life forgetting in transient epileptic amnesia via an incidental memory test.
    (Elsevier, 2017-12-13) Hoefeijzers, S.; Zeman, Adam; Della Sala, S.; Dewar, M.
    Transient epileptic amnesia (TEA) is an epileptic syndrome characterized by recurrent, brief episodes of amnesia. Patients with TEA often complain of interictal (between attacks) retention deficits, characterised by an 'evaporation' of memories for recent events over days to weeks. Clinical tests of anterograde memory often fail to corroborate these complaints as TEA patients commonly perform within the normal range after the standard 10-30-min delay period. Modified laboratory tests that include a 1-3 week delay period frequently reveal clear evidence of 'accelerated long-term forgetting' (ALF). However, they are not used routinely and lack ecological validity. In the present study we examined whether 'real-life' ALF can be captured via a controlled incidental memory test in TEA patients. To this end, the experimenter told 27 TEA patients and 32 controls a well-rehearsed amusing story, apparently as a way of making light conversation before starting a set of research experiments. Without prior warning, the experimenter subsequently probed the participants' memory of this story via tests of free recall and forced choice recognition after 30 min or 1 week. After 30 min retention was comparable in TEA patients and controls. After 1 week TEA patients retained significantly less story material than controls, and significant ALF was revealed in the TEA patients in the recognition test. Our data show that ALF in a 'real-life' situation can occur even when standard memory tests indicate normal memory function. Moreover, our data suggest that incidental memory tests can capture real-life ALF, and that forced-choice recognition tests might be more sensitive than free recall tests for the detection of real-life ALF.
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    Recommendations for a first Core Outcome Measurement set for complex regional PAin syndrome Clinical sTudies (COMPACT).
    (Wolters Kluwer, 2017-06) Grieve, S.; Perez, R. S. G. M.; Birklein, F.; Brunner, F.; Bruehl, S.; Harden, R. N.; Packham, T.; Gobeil, F.; Haigh, Richard; Holly, J.; Terkelsen, A.; Davies, L.; Lewis, J.; Thomassen, I.; Connett, R.; Worth, T.; Vatine, J-J; McCabe, C. S.
    Complex regional pain syndrome (CRPS) is a persistent pain condition that remains incompletely understood and challenging to treat. Historically, a wide range of different outcome measures have been used to capture the multidimensional nature of CRPS. This has been a significant limiting factor in the advancement of our understanding of the mechanisms and management of CRPS. In 2013, an international consortium of patients, clinicians, researchers, and industry representatives was established, to develop and agree on a minimum core set of standardised outcome measures for use in future CRPS clinical research, including but not limited to clinical trials within adult populations. The development of a core measurement set was informed through workshops and supplementary work, using an iterative consensus process. "What is the clinical presentation and course of CRPS, and what factors influence it?" was agreed as the most pertinent research question that our standardised set of patient-reported outcome measures should be selected to answer. The domains encompassing the key concepts necessary to answer the research question were agreed as follows: pain, disease severity, participation and physical function, emotional and psychological function, self-efficacy, catastrophizing, and patient's global impression of change. The final core measurement set included the optimum generic or condition-specific patient-reported questionnaire outcome measures, which captured the essence of each domain, and 1 clinician-reported outcome measure to capture the degree of severity of CRPS. The next step is to test the feasibility and acceptability of collecting outcome measure data using the core measurement set in the CRPS population internationally.